Tags

Type your tag names separated by a space and hit enter

Hepatic lipase gene -514C/T polymorphism in the Guangxi Hei Yi Zhuang and Han populations.
Lipids. 2008 Aug; 43(8):733-40.L

Abstract

Hei Yi Zhuang is an isolated subgroup of the Zhuang minority in China. This study was designed to compare the difference in the hepatic lipase gene (LIPC) -514C/T polymorphism and its association with lipid profiles between the Guangxi Hei Yi Zhuang and Han populations. Genotyping of the LIPC -514C/T was performed in 873 subjects of Hei Yi Zhuang and 867 participants of Han Chinese. The frequency of -514T allele was 43.47% in Hei Yi Zhuang, and 36.10% in Han (P < 0.001). The frequencies of CC, CT and TT genotypes were 30.01, 53.04 and 16.95% in Hei Yi Zhuang, and 40.95, 45.91 and 13.14% in Han (P < 0.001); respectively. Serum high-density lipoprotein cholesterol (HDL-C) and apolipoprotein B levels in both ethnic groups were higher in LIPC -514T carriers than in C carriers. In addition, serum triglyceride levels in Han were higher in TT genotype individuals than in CC genotype subjects (P < 0.05). Serum HDL-C levels were positively correlated with age, alcohol consumption and LIPC -514C/T genotypes, and negatively associated with hypertension and cigarette smoking in Hei Yi Zhuang (P < 0.05-0.01), whereas HDL-C levels were positively correlated with age, alcohol consumption and LIPC -514C/T genotypes, and negatively associated with body mass index and cigarette smoking in Han (P < 0.05-0.001). The differences in serum HDL-C levels between the two ethnic groups might partially attribute to the differences in the LIPC -514C/T polymorphism.

Authors+Show Affiliations

Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, 530021, Nanning, Guangxi, People's Republic of China. yinrx2003@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18592285

Citation

Wu, Jinzhen, et al. "Hepatic Lipase Gene -514C/T Polymorphism in the Guangxi Hei Yi Zhuang and Han Populations." Lipids, vol. 43, no. 8, 2008, pp. 733-40.
Wu J, Yin R, Lin W, et al. Hepatic lipase gene -514C/T polymorphism in the Guangxi Hei Yi Zhuang and Han populations. Lipids. 2008;43(8):733-40.
Wu, J., Yin, R., Lin, W., Pan, S., & Yang, D. (2008). Hepatic lipase gene -514C/T polymorphism in the Guangxi Hei Yi Zhuang and Han populations. Lipids, 43(8), 733-40. https://doi.org/10.1007/s11745-008-3204-3
Wu J, et al. Hepatic Lipase Gene -514C/T Polymorphism in the Guangxi Hei Yi Zhuang and Han Populations. Lipids. 2008;43(8):733-40. PubMed PMID: 18592285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatic lipase gene -514C/T polymorphism in the Guangxi Hei Yi Zhuang and Han populations. AU - Wu,Jinzhen, AU - Yin,Ruixing, AU - Lin,Weixiong, AU - Pan,Shangling, AU - Yang,Dezhai, Y1 - 2008/07/01/ PY - 2008/03/20/received PY - 2008/06/06/accepted PY - 2008/7/2/pubmed PY - 2009/2/12/medline PY - 2008/7/2/entrez SP - 733 EP - 40 JF - Lipids JO - Lipids VL - 43 IS - 8 N2 - Hei Yi Zhuang is an isolated subgroup of the Zhuang minority in China. This study was designed to compare the difference in the hepatic lipase gene (LIPC) -514C/T polymorphism and its association with lipid profiles between the Guangxi Hei Yi Zhuang and Han populations. Genotyping of the LIPC -514C/T was performed in 873 subjects of Hei Yi Zhuang and 867 participants of Han Chinese. The frequency of -514T allele was 43.47% in Hei Yi Zhuang, and 36.10% in Han (P < 0.001). The frequencies of CC, CT and TT genotypes were 30.01, 53.04 and 16.95% in Hei Yi Zhuang, and 40.95, 45.91 and 13.14% in Han (P < 0.001); respectively. Serum high-density lipoprotein cholesterol (HDL-C) and apolipoprotein B levels in both ethnic groups were higher in LIPC -514T carriers than in C carriers. In addition, serum triglyceride levels in Han were higher in TT genotype individuals than in CC genotype subjects (P < 0.05). Serum HDL-C levels were positively correlated with age, alcohol consumption and LIPC -514C/T genotypes, and negatively associated with hypertension and cigarette smoking in Hei Yi Zhuang (P < 0.05-0.01), whereas HDL-C levels were positively correlated with age, alcohol consumption and LIPC -514C/T genotypes, and negatively associated with body mass index and cigarette smoking in Han (P < 0.05-0.001). The differences in serum HDL-C levels between the two ethnic groups might partially attribute to the differences in the LIPC -514C/T polymorphism. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/18592285/Hepatic_lipase_gene__514C/T_polymorphism_in_the_Guangxi_Hei_Yi_Zhuang_and_Han_populations_ L2 - https://link.springer.com/article/10.1007/s11745-008-3204-3 DB - PRIME DP - Unbound Medicine ER -