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Dietary patterns and risk of bladder cancer: a factor analysis in Uruguay.
Cancer Causes Control 2008; 19(10):1243-9CC

Abstract

OBJECTIVE

To determine the major dietary patterns associated with bladder cancer risk, we conducted a principal components analysis (PCA) in a case-control study from Uruguay.

METHODS

A total of 255 newly diagnosed and microscopically confirmed cases of transitional cell carcinoma of the bladder and 501 hospitalized controls were included in the study. Both series were drawn from the four major public hospitals in Montevideo, Uruguay. Cases and controls were frequency matched on age and sex. Controls were submitted to factor (principal components) analysis.

RESULTS

We retained three factors that explained 25.1% of the total variance (including error variance). The first factor was labeled as the sweet beverages pattern. This factor was characterized by high loadings of coffee, tea, and added sugar and was strongly associated with risk of bladder cancer (OR 3.27, 95% CI 1.96-5.45). The second factor was labeled as the Western pattern and displayed high loadings of red meat, fried eggs, potatoes, and red wine. This pattern was directly associated with risk of bladder cancer (OR 2.35, 95% CI 1.42-3.89). Finally, the third factor was labeled as the prudent pattern and showed high loadings of fresh vegetables, cooked vegetables, and fruits. This pattern was not associated with risk of bladder cancer.

CONCLUSIONS

According to our study, non-alcoholic beverages were the strongest risk factor for bladder cancer, whereas the Western pattern was also associated with a significant increase in risk of bladder cancer.

Authors+Show Affiliations

Departamento de Anatomía Patológica, Facultad de Medicina, Hospital de Clínicas, Montevideo, Uruguay. estefani@adinet.com.uyNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18592382

Citation

De Stefani, Eduardo, et al. "Dietary Patterns and Risk of Bladder Cancer: a Factor Analysis in Uruguay." Cancer Causes & Control : CCC, vol. 19, no. 10, 2008, pp. 1243-9.
De Stefani E, Boffetta P, Ronco AL, et al. Dietary patterns and risk of bladder cancer: a factor analysis in Uruguay. Cancer Causes Control. 2008;19(10):1243-9.
De Stefani, E., Boffetta, P., Ronco, A. L., Deneo-Pellegrini, H., Acosta, G., & Mendilaharsu, M. (2008). Dietary patterns and risk of bladder cancer: a factor analysis in Uruguay. Cancer Causes & Control : CCC, 19(10), pp. 1243-9. doi:10.1007/s10552-008-9195-9.
De Stefani E, et al. Dietary Patterns and Risk of Bladder Cancer: a Factor Analysis in Uruguay. Cancer Causes Control. 2008;19(10):1243-9. PubMed PMID: 18592382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary patterns and risk of bladder cancer: a factor analysis in Uruguay. AU - De Stefani,Eduardo, AU - Boffetta,Paolo, AU - Ronco,Alvaro L, AU - Deneo-Pellegrini,Hugo, AU - Acosta,Giselle, AU - Mendilaharsu,María, Y1 - 2008/07/01/ PY - 2007/11/18/received PY - 2008/06/05/accepted PY - 2008/7/2/pubmed PY - 2009/2/13/medline PY - 2008/7/2/entrez SP - 1243 EP - 9 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 19 IS - 10 N2 - OBJECTIVE: To determine the major dietary patterns associated with bladder cancer risk, we conducted a principal components analysis (PCA) in a case-control study from Uruguay. METHODS: A total of 255 newly diagnosed and microscopically confirmed cases of transitional cell carcinoma of the bladder and 501 hospitalized controls were included in the study. Both series were drawn from the four major public hospitals in Montevideo, Uruguay. Cases and controls were frequency matched on age and sex. Controls were submitted to factor (principal components) analysis. RESULTS: We retained three factors that explained 25.1% of the total variance (including error variance). The first factor was labeled as the sweet beverages pattern. This factor was characterized by high loadings of coffee, tea, and added sugar and was strongly associated with risk of bladder cancer (OR 3.27, 95% CI 1.96-5.45). The second factor was labeled as the Western pattern and displayed high loadings of red meat, fried eggs, potatoes, and red wine. This pattern was directly associated with risk of bladder cancer (OR 2.35, 95% CI 1.42-3.89). Finally, the third factor was labeled as the prudent pattern and showed high loadings of fresh vegetables, cooked vegetables, and fruits. This pattern was not associated with risk of bladder cancer. CONCLUSIONS: According to our study, non-alcoholic beverages were the strongest risk factor for bladder cancer, whereas the Western pattern was also associated with a significant increase in risk of bladder cancer. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/18592382/Dietary_patterns_and_risk_of_bladder_cancer:_a_factor_analysis_in_Uruguay_ L2 - https://doi.org/10.1007/s10552-008-9195-9 DB - PRIME DP - Unbound Medicine ER -