Tags

Type your tag names separated by a space and hit enter

Dietary intake of carotenoids and retinol and endometrial cancer risk in an Italian case-control study.
Cancer Causes Control 2008; 19(10):1209-15CC

Abstract

OBJECTIVES

To provide information on the relation between intake of carotenoids and retinol and endometrial cancer, since available data are inconsistent. Further, carotenoids other than beta-carotene have been rarely investigated.

METHODS

We conducted a multi-centric case-control study in various areas of Italy between 1992 and 2006 on 454 women with incident, histologically confirmed endometrial cancer and 908 controls admitted to the same network of hospitals of cases for acute, non-neoplastic conditions. Intake of carotenoids and retinol was computed from a validated and reproducible food frequency questionnaire. We adjusted for selected covariates, including energy intake, and calculated multivariate odds ratios (OR) and 95% confidence intervals (CI) using conditional logistic regression.

RESULTS

Comparing the highest to the lowest quartile of intake, the ORs of endometrial cancer were 0.69 (95% CI, 0.48-0.99) for beta-carotene, 0.65 (95% CI, 0.45-0.94) for beta-cryptoxanthin, and 0.59 (95% CI, 0.41-0.85) for lutein plus zeaxanthin intake. No association emerged with retinol (OR = 1.31, 95% CI, 0.94-1.84), alpha-carotene (OR = 0.94, 95% CI, 0.66-1.34), and lycopene (OR = 0.95, 95% CI, 0.68-1.34).

CONCLUSIONS

Our results support a favorable role of selected dietary carotenoids on endometrial cancer risk.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. pelucchi@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18592384

Citation

Pelucchi, Claudio, et al. "Dietary Intake of Carotenoids and Retinol and Endometrial Cancer Risk in an Italian Case-control Study." Cancer Causes & Control : CCC, vol. 19, no. 10, 2008, pp. 1209-15.
Pelucchi C, Dal Maso L, Montella M, et al. Dietary intake of carotenoids and retinol and endometrial cancer risk in an Italian case-control study. Cancer Causes Control. 2008;19(10):1209-15.
Pelucchi, C., Dal Maso, L., Montella, M., Parpinel, M., Negri, E., Talamini, R., ... La Vecchia, C. (2008). Dietary intake of carotenoids and retinol and endometrial cancer risk in an Italian case-control study. Cancer Causes & Control : CCC, 19(10), pp. 1209-15. doi:10.1007/s10552-008-9190-1.
Pelucchi C, et al. Dietary Intake of Carotenoids and Retinol and Endometrial Cancer Risk in an Italian Case-control Study. Cancer Causes Control. 2008;19(10):1209-15. PubMed PMID: 18592384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of carotenoids and retinol and endometrial cancer risk in an Italian case-control study. AU - Pelucchi,Claudio, AU - Dal Maso,Luigino, AU - Montella,Maurizio, AU - Parpinel,Maria, AU - Negri,Eva, AU - Talamini,Renato, AU - Giudice,Aldo, AU - Franceschi,Silvia, AU - La Vecchia,Carlo, Y1 - 2008/07/01/ PY - 2007/10/31/received PY - 2008/06/09/accepted PY - 2008/7/2/pubmed PY - 2009/2/13/medline PY - 2008/7/2/entrez SP - 1209 EP - 15 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 19 IS - 10 N2 - OBJECTIVES: To provide information on the relation between intake of carotenoids and retinol and endometrial cancer, since available data are inconsistent. Further, carotenoids other than beta-carotene have been rarely investigated. METHODS: We conducted a multi-centric case-control study in various areas of Italy between 1992 and 2006 on 454 women with incident, histologically confirmed endometrial cancer and 908 controls admitted to the same network of hospitals of cases for acute, non-neoplastic conditions. Intake of carotenoids and retinol was computed from a validated and reproducible food frequency questionnaire. We adjusted for selected covariates, including energy intake, and calculated multivariate odds ratios (OR) and 95% confidence intervals (CI) using conditional logistic regression. RESULTS: Comparing the highest to the lowest quartile of intake, the ORs of endometrial cancer were 0.69 (95% CI, 0.48-0.99) for beta-carotene, 0.65 (95% CI, 0.45-0.94) for beta-cryptoxanthin, and 0.59 (95% CI, 0.41-0.85) for lutein plus zeaxanthin intake. No association emerged with retinol (OR = 1.31, 95% CI, 0.94-1.84), alpha-carotene (OR = 0.94, 95% CI, 0.66-1.34), and lycopene (OR = 0.95, 95% CI, 0.68-1.34). CONCLUSIONS: Our results support a favorable role of selected dietary carotenoids on endometrial cancer risk. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/18592384/Dietary_intake_of_carotenoids_and_retinol_and_endometrial_cancer_risk_in_an_Italian_case_control_study_ L2 - https://doi.org/10.1007/s10552-008-9190-1 DB - PRIME DP - Unbound Medicine ER -