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Retinal nerve fiber layer measures in high- and normal-tension glaucoma.
Optom Vis Sci 2008; 85(7):538-42OV

Abstract

PURPOSE

To use optical coherence tomography (OCT) to investigate the qualitative and quantitative differences in the defects of the retinal nerve fiber layer (RNFL) in subjects with high tension primary open angle glaucoma and subjects with normal tension glaucoma.

METHODS

RNFL was assessed with OCT in 21 eyes with high-tension glaucoma (HTG) and 20 eyes with normal-tension glaucoma (NTG). Regression analyses were performed to investigate the interaction of disease group and location for localized RNFL loss, and to predict diffuse and localized RNFL loss as a function of age, mean defect, spherical equivalent, disease group, and location. Local RNFL thicknesses for superior clock-hour regions were estimated after adjustment for the thicknesses of symmetrically opposed locations.

RESULTS

There were no differences in mean age, visual field defect mean deviation, and refractive error between subjects in HTG and NTG groups. Diffuse RNFL thickness was not significantly different between the two groups [mean RNFL for NTG > HTG by 3.48 mum, 95% confidence interval (CI) -3.9 to 10.9 microm, p = 0.092]. There was no significant interaction of group and location for localized RNFL loss (p = 0.916). Local RNFL thickness at superior regions was not significantly different in the two groups, after adjustment for RNFL thickness at corresponding inferior locations (mean RNFL for NTG > HTG by 6.30 microm, 95% CI -1.08 to 13.7 microm, p = 0.34). RNFL thickness decreased, on average (1.88 microm/dB mean deviation, 95% CI 1.21 to 2.55 microm, p < 0.0001) and locally (1.37 microm/dB mean deviation, 95% CI 0.79 to 1.96 microm, p < 0.0001), with increasing severity of glaucoma.

CONCLUSION

There is no difference in the spatial pattern of RNFL defects, as assessed by the OCT, between HTG and NTG.

Authors+Show Affiliations

Manchester Royal Eye Hospital, Manchester, United Kingdom. evgeniakonst@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18594346

Citation

Konstantakopoulou, Evgenia, et al. "Retinal Nerve Fiber Layer Measures in High- and Normal-tension Glaucoma." Optometry and Vision Science : Official Publication of the American Academy of Optometry, vol. 85, no. 7, 2008, pp. 538-42.
Konstantakopoulou E, Reeves BC, Fenerty C, et al. Retinal nerve fiber layer measures in high- and normal-tension glaucoma. Optom Vis Sci. 2008;85(7):538-42.
Konstantakopoulou, E., Reeves, B. C., Fenerty, C., & Harper, R. A. (2008). Retinal nerve fiber layer measures in high- and normal-tension glaucoma. Optometry and Vision Science : Official Publication of the American Academy of Optometry, 85(7), pp. 538-42. doi:10.1097/OPX.0b013e31817dad6a.
Konstantakopoulou E, et al. Retinal Nerve Fiber Layer Measures in High- and Normal-tension Glaucoma. Optom Vis Sci. 2008;85(7):538-42. PubMed PMID: 18594346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal nerve fiber layer measures in high- and normal-tension glaucoma. AU - Konstantakopoulou,Evgenia, AU - Reeves,Barnaby C, AU - Fenerty,Cecilia, AU - Harper,Robert A, PY - 2008/7/3/pubmed PY - 2008/8/19/medline PY - 2008/7/3/entrez SP - 538 EP - 42 JF - Optometry and vision science : official publication of the American Academy of Optometry JO - Optom Vis Sci VL - 85 IS - 7 N2 - PURPOSE: To use optical coherence tomography (OCT) to investigate the qualitative and quantitative differences in the defects of the retinal nerve fiber layer (RNFL) in subjects with high tension primary open angle glaucoma and subjects with normal tension glaucoma. METHODS: RNFL was assessed with OCT in 21 eyes with high-tension glaucoma (HTG) and 20 eyes with normal-tension glaucoma (NTG). Regression analyses were performed to investigate the interaction of disease group and location for localized RNFL loss, and to predict diffuse and localized RNFL loss as a function of age, mean defect, spherical equivalent, disease group, and location. Local RNFL thicknesses for superior clock-hour regions were estimated after adjustment for the thicknesses of symmetrically opposed locations. RESULTS: There were no differences in mean age, visual field defect mean deviation, and refractive error between subjects in HTG and NTG groups. Diffuse RNFL thickness was not significantly different between the two groups [mean RNFL for NTG > HTG by 3.48 mum, 95% confidence interval (CI) -3.9 to 10.9 microm, p = 0.092]. There was no significant interaction of group and location for localized RNFL loss (p = 0.916). Local RNFL thickness at superior regions was not significantly different in the two groups, after adjustment for RNFL thickness at corresponding inferior locations (mean RNFL for NTG > HTG by 6.30 microm, 95% CI -1.08 to 13.7 microm, p = 0.34). RNFL thickness decreased, on average (1.88 microm/dB mean deviation, 95% CI 1.21 to 2.55 microm, p < 0.0001) and locally (1.37 microm/dB mean deviation, 95% CI 0.79 to 1.96 microm, p < 0.0001), with increasing severity of glaucoma. CONCLUSION: There is no difference in the spatial pattern of RNFL defects, as assessed by the OCT, between HTG and NTG. SN - 1040-5488 UR - https://www.unboundmedicine.com/medline/citation/18594346/Retinal_nerve_fiber_layer_measures_in_high__and_normal_tension_glaucoma_ L2 - http://Insights.ovid.com/pubmed?pmid=18594346 DB - PRIME DP - Unbound Medicine ER -