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Circulating soluble receptor for advanced glycation end products is inversely associated with body mass index and waist/hip ratio in the general population.
Nutr Metab Cardiovasc Dis 2009; 19(2):129-34NM

Abstract

Advanced glycation end products, AGEs, and its specific receptor, RAGE, are involved in vascular complications. A role for the soluble form of RAGE (sRAGE), which acts as a decoy for AGE, has been documented in patients with diabetes but no information is available in non-diabetic subjects. The aim of this study was to investigate the association of plasma levels of sRAGE with cardiometabolic risk factors in the general population. In addition we evaluated the relation of the common -374A/T polymorphism of RAGE with plasma levels of sRAGE. One hundred and seventy-six healthy subjects free of diabetes or coronary artery disease untreated for hypertension, dyslipidemia or cardiometabolic related diseases were randomly selected for this study from the general population. Plasma sRAGE were negatively and significantly correlated with BMI, waist/hip circumference ratio and fasting glycemia, while a positive correlation was observed with apolipoprotein A-I. These correlations were observed mainly in women who showed significantly higher sRAGE levels (1744+/-660 pg/mL vs 1414+/-649 pg/mL; P<0.05). In a stepwise regression analysis waist circumference was independently associated with sRAGE and, when waist circumference was excluded, BMI was independently associated with sRAGE. Finally in overweight subjects (BMI>25 kg/m(2)) plasma sRAGE was significantly lower compared to lean subjects (1460+/-640 pg/mL vs 1710+/-693 pg/mL; P<0.05). In healthy subjects plasma levels of sRAGE were negatively correlated with BMI and waist/hip ratio supporting a possible protective role for these proteins before any evidence of diabetic or vascular complications.

Authors+Show Affiliations

Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy. danilo.norata@unimi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18595673

Citation

Norata, Giuseppe Danilo, et al. "Circulating Soluble Receptor for Advanced Glycation End Products Is Inversely Associated With Body Mass Index and Waist/hip Ratio in the General Population." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 19, no. 2, 2009, pp. 129-34.
Norata GD, Garlaschelli K, Grigore L, et al. Circulating soluble receptor for advanced glycation end products is inversely associated with body mass index and waist/hip ratio in the general population. Nutr Metab Cardiovasc Dis. 2009;19(2):129-34.
Norata, G. D., Garlaschelli, K., Grigore, L., Tibolla, G., Raselli, S., Redaelli, L., ... Catapano, A. L. (2009). Circulating soluble receptor for advanced glycation end products is inversely associated with body mass index and waist/hip ratio in the general population. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 19(2), pp. 129-34. doi:10.1016/j.numecd.2008.03.004.
Norata GD, et al. Circulating Soluble Receptor for Advanced Glycation End Products Is Inversely Associated With Body Mass Index and Waist/hip Ratio in the General Population. Nutr Metab Cardiovasc Dis. 2009;19(2):129-34. PubMed PMID: 18595673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating soluble receptor for advanced glycation end products is inversely associated with body mass index and waist/hip ratio in the general population. AU - Norata,Giuseppe Danilo, AU - Garlaschelli,Katia, AU - Grigore,Liliana, AU - Tibolla,Gianpaolo, AU - Raselli,Sara, AU - Redaelli,Laura, AU - Buccianti,Gherardo, AU - Catapano,Alberico Luigi, Y1 - 2008/07/02/ PY - 2007/12/04/received PY - 2008/02/28/revised PY - 2008/03/11/accepted PY - 2008/7/4/pubmed PY - 2009/5/1/medline PY - 2008/7/4/entrez SP - 129 EP - 34 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 19 IS - 2 N2 - Advanced glycation end products, AGEs, and its specific receptor, RAGE, are involved in vascular complications. A role for the soluble form of RAGE (sRAGE), which acts as a decoy for AGE, has been documented in patients with diabetes but no information is available in non-diabetic subjects. The aim of this study was to investigate the association of plasma levels of sRAGE with cardiometabolic risk factors in the general population. In addition we evaluated the relation of the common -374A/T polymorphism of RAGE with plasma levels of sRAGE. One hundred and seventy-six healthy subjects free of diabetes or coronary artery disease untreated for hypertension, dyslipidemia or cardiometabolic related diseases were randomly selected for this study from the general population. Plasma sRAGE were negatively and significantly correlated with BMI, waist/hip circumference ratio and fasting glycemia, while a positive correlation was observed with apolipoprotein A-I. These correlations were observed mainly in women who showed significantly higher sRAGE levels (1744+/-660 pg/mL vs 1414+/-649 pg/mL; P<0.05). In a stepwise regression analysis waist circumference was independently associated with sRAGE and, when waist circumference was excluded, BMI was independently associated with sRAGE. Finally in overweight subjects (BMI>25 kg/m(2)) plasma sRAGE was significantly lower compared to lean subjects (1460+/-640 pg/mL vs 1710+/-693 pg/mL; P<0.05). In healthy subjects plasma levels of sRAGE were negatively correlated with BMI and waist/hip ratio supporting a possible protective role for these proteins before any evidence of diabetic or vascular complications. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/18595673/Circulating_soluble_receptor_for_advanced_glycation_end_products_is_inversely_associated_with_body_mass_index_and_waist/hip_ratio_in_the_general_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(08)00064-1 DB - PRIME DP - Unbound Medicine ER -