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Age at first introduction of cow milk products and other food products in relation to infant atopic manifestations in the first 2 years of life: the KOALA Birth Cohort Study.
Pediatrics. 2008 Jul; 122(1):e115-22.Ped

Abstract

OBJECTIVES

Scientific evidence is scarce about timing of solid-food introduction and its association with the development of atopy. We aimed to evaluate any associations between the introduction of cow milk products/other solid food products and infant atopic manifestations in the second year of life, taking into account reverse causation.

METHODS

Data from 2558 infants in an ongoing prospective birth cohort study in the Netherlands were analyzed. Data on the main determinants (introduction of cow milk products and other food products), outcomes (eczema; atopic dermatitis [United Kingdom Working Party criteria]; recurrent wheeze; any sensitization; sensitization against cow milk, hen egg, peanut, and at least 1 inhalant allergen), and confounders were collected by repeated questionnaires at 34 weeks of gestation and 3, 7, 12, and 24 months postpartum. Information on sensitization was gathered by venous blood collections performed during home visits at age 2. Analyses were performed by multiple logistic regression analyses.

RESULTS

More delay in introduction of cow milk products was associated with a higher risk for eczema. In addition, a delayed introduction of other food products was associated with an increased risk for atopy development at the age of 2 years. Exclusion of infants with early symptoms of eczema and recurrent wheeze (to avoid reverse causation) did not essentially change our results.

DISCUSSION

Delaying the introduction of cow milk or other food products may not be favorable in preventing the development of atopy.

Authors+Show Affiliations

Department of Epidemiology, Care and Public Health Research Institute, Maastricht University, PO Box 616, 6200 MD Maastricht, Netherlands. bep.snijders@epid.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18595956

Citation

Snijders, Bianca E P., et al. "Age at First Introduction of Cow Milk Products and Other Food Products in Relation to Infant Atopic Manifestations in the First 2 Years of Life: the KOALA Birth Cohort Study." Pediatrics, vol. 122, no. 1, 2008, pp. e115-22.
Snijders BE, Thijs C, van Ree R, et al. Age at first introduction of cow milk products and other food products in relation to infant atopic manifestations in the first 2 years of life: the KOALA Birth Cohort Study. Pediatrics. 2008;122(1):e115-22.
Snijders, B. E., Thijs, C., van Ree, R., & van den Brandt, P. A. (2008). Age at first introduction of cow milk products and other food products in relation to infant atopic manifestations in the first 2 years of life: the KOALA Birth Cohort Study. Pediatrics, 122(1), e115-22. https://doi.org/10.1542/peds.2007-1651
Snijders BE, et al. Age at First Introduction of Cow Milk Products and Other Food Products in Relation to Infant Atopic Manifestations in the First 2 Years of Life: the KOALA Birth Cohort Study. Pediatrics. 2008;122(1):e115-22. PubMed PMID: 18595956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age at first introduction of cow milk products and other food products in relation to infant atopic manifestations in the first 2 years of life: the KOALA Birth Cohort Study. AU - Snijders,Bianca E P, AU - Thijs,Carel, AU - van Ree,Ronald, AU - van den Brandt,Piet A, PY - 2008/7/4/pubmed PY - 2008/8/1/medline PY - 2008/7/4/entrez SP - e115 EP - 22 JF - Pediatrics JO - Pediatrics VL - 122 IS - 1 N2 - OBJECTIVES: Scientific evidence is scarce about timing of solid-food introduction and its association with the development of atopy. We aimed to evaluate any associations between the introduction of cow milk products/other solid food products and infant atopic manifestations in the second year of life, taking into account reverse causation. METHODS: Data from 2558 infants in an ongoing prospective birth cohort study in the Netherlands were analyzed. Data on the main determinants (introduction of cow milk products and other food products), outcomes (eczema; atopic dermatitis [United Kingdom Working Party criteria]; recurrent wheeze; any sensitization; sensitization against cow milk, hen egg, peanut, and at least 1 inhalant allergen), and confounders were collected by repeated questionnaires at 34 weeks of gestation and 3, 7, 12, and 24 months postpartum. Information on sensitization was gathered by venous blood collections performed during home visits at age 2. Analyses were performed by multiple logistic regression analyses. RESULTS: More delay in introduction of cow milk products was associated with a higher risk for eczema. In addition, a delayed introduction of other food products was associated with an increased risk for atopy development at the age of 2 years. Exclusion of infants with early symptoms of eczema and recurrent wheeze (to avoid reverse causation) did not essentially change our results. DISCUSSION: Delaying the introduction of cow milk or other food products may not be favorable in preventing the development of atopy. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/18595956/Age_at_first_introduction_of_cow_milk_products_and_other_food_products_in_relation_to_infant_atopic_manifestations_in_the_first_2_years_of_life:_the_KOALA_Birth_Cohort_Study_ DB - PRIME DP - Unbound Medicine ER -