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Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats.
Psychopharmacology (Berl). 2008 Nov; 200(4):545-56.P

Abstract

RATIONALE

The nucleus accumbens (NAC) is a functionally heterogeneous brain region with respect to its involvement in cocaine-seeking behavior triggered by drug-associated explicit conditioned stimuli, foot shock stress, or cocaine itself in the reinstatement animal model of drug relapse. However, it is not known whether the NAC or its subregions are critical for reinstatement of cocaine-seeking behavior produced by re-exposure to a previously cocaine-paired environmental context.

OBJECTIVES

The present study was designed to evaluate potentially unique contributions of the NAC core and shell to this behavior.

MATERIALS AND METHODS

Rats were trained to lever press for unsignaled cocaine infusions (0.15 mg/infusion, intravenous) in a distinct environmental context. Lever responding was then extinguished in a distinctly different environmental context (extinction context) during a minimum of seven daily training sessions. Subsequently, using a counterbalanced testing design, rats were re-exposed to the cocaine-paired context or the extinction context while cocaine seeking (i.e., responding on the previously cocaine-reinforced lever) was assessed. Before each test session, neural activity was inhibited selectively in the NAC core or shell using bilateral microinfusions of the gamma-aminobutyric acid agonists, baclofen and muscimol (0/0 or 1.0/0.1 mM; 0.3 microl per hemisphere).

RESULTS

Neural inactivation of the NAC shell or core attenuated responding in the cocaine context and, interestingly, increased responding in the extinction context. Control experiments indicated no effects on general activity or food-reinforced instrumental behavior.

CONCLUSIONS

These findings suggest that both subregions of the NAC may promote context-induced reinstatement by facilitating drug context-induced motivation for cocaine and context discrimination.

Authors+Show Affiliations

Department of Psychology, University of North Carolina, CB no. 3270, Davie Hall, Chapel Hill, NC 27599-3270, USA. rfuchs@unc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18597075

Citation

Fuchs, Rita A., et al. "Nucleus Accumbens Shell and Core Involvement in Drug Context-induced Reinstatement of Cocaine Seeking in Rats." Psychopharmacology, vol. 200, no. 4, 2008, pp. 545-56.
Fuchs RA, Ramirez DR, Bell GH. Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl). 2008;200(4):545-56.
Fuchs, R. A., Ramirez, D. R., & Bell, G. H. (2008). Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats. Psychopharmacology, 200(4), 545-56. https://doi.org/10.1007/s00213-008-1234-4
Fuchs RA, Ramirez DR, Bell GH. Nucleus Accumbens Shell and Core Involvement in Drug Context-induced Reinstatement of Cocaine Seeking in Rats. Psychopharmacology (Berl). 2008;200(4):545-56. PubMed PMID: 18597075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats. AU - Fuchs,Rita A, AU - Ramirez,Donna R, AU - Bell,Guinevere H, Y1 - 2008/07/04/ PY - 2008/04/07/received PY - 2008/06/09/accepted PY - 2008/7/4/pubmed PY - 2009/1/30/medline PY - 2008/7/4/entrez SP - 545 EP - 56 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 200 IS - 4 N2 - RATIONALE: The nucleus accumbens (NAC) is a functionally heterogeneous brain region with respect to its involvement in cocaine-seeking behavior triggered by drug-associated explicit conditioned stimuli, foot shock stress, or cocaine itself in the reinstatement animal model of drug relapse. However, it is not known whether the NAC or its subregions are critical for reinstatement of cocaine-seeking behavior produced by re-exposure to a previously cocaine-paired environmental context. OBJECTIVES: The present study was designed to evaluate potentially unique contributions of the NAC core and shell to this behavior. MATERIALS AND METHODS: Rats were trained to lever press for unsignaled cocaine infusions (0.15 mg/infusion, intravenous) in a distinct environmental context. Lever responding was then extinguished in a distinctly different environmental context (extinction context) during a minimum of seven daily training sessions. Subsequently, using a counterbalanced testing design, rats were re-exposed to the cocaine-paired context or the extinction context while cocaine seeking (i.e., responding on the previously cocaine-reinforced lever) was assessed. Before each test session, neural activity was inhibited selectively in the NAC core or shell using bilateral microinfusions of the gamma-aminobutyric acid agonists, baclofen and muscimol (0/0 or 1.0/0.1 mM; 0.3 microl per hemisphere). RESULTS: Neural inactivation of the NAC shell or core attenuated responding in the cocaine context and, interestingly, increased responding in the extinction context. Control experiments indicated no effects on general activity or food-reinforced instrumental behavior. CONCLUSIONS: These findings suggest that both subregions of the NAC may promote context-induced reinstatement by facilitating drug context-induced motivation for cocaine and context discrimination. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/18597075/Nucleus_accumbens_shell_and_core_involvement_in_drug_context_induced_reinstatement_of_cocaine_seeking_in_rats_ L2 - https://dx.doi.org/10.1007/s00213-008-1234-4 DB - PRIME DP - Unbound Medicine ER -