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Soluble endothelial cell adhesion molecules and their relationship to disease activity in Takayasu's arteritis.
J Rheumatol. 2008 Sep; 35(9):1842-5.JR

Abstract

OBJECTIVE

To investigate soluble (s) E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1), and their relationship to disease activity in Takayasu's arteritis (TA).

METHODS

Levels of adhesion molecules were measured by enzyme immunoassay in the sera of 35 patients with TA, 17 healthy controls, and 15 patients with 12 months followup.

RESULTS

Compared to controls, patients had elevated levels of sE-selectin (54.5 +/- 35.0 vs 36.4 +/- 13.0 ng/ml, p < 0.05), sVCAM-1 (280.9 +/- 267.6 vs 141.2 +/- 76.1 ng/ml, p < 0.05), and sICAM-1 (261.3 +/- 168.1 vs 198.3 +/- 74.3 ng/ml, p < 0.05). Compared to controls, patients with inactive TA also had elevated levels of sE-selectin (67.4 +/- 45.9 vs 36.4 +/- 13.0 ng/ml, p < 0.02), sVCAM-1 (327.6 +/- 327.8 vs 141.2 +/- 76.1 ng/ml, p < 0.02), and sICAM-1 (321.9 +/- 179.5 vs 198.3 +/- 74.3 ng/ml, p < 0.02). There was no difference between active TA and controls. sE-selectin had a trend towards increased levels in inactive versus active TA (67.4 +/- 45.9 vs 44.9 +/- 20.3 ng/ml p = 0.059), but there was no difference in sVCAM-1 and sICAM-1 levels between the groups. No adhesion molecule levels showed a change among followup patients.

CONCLUSION

Patients with inactive TA have elevated levels of sE-selectin, sVCAM-1, and sICAM-1 that might indicate persistent vasculopathy in clinically inactive disease.

Authors+Show Affiliations

Department of Hematology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18597403

Citation

Tripathy, Naresh K., et al. "Soluble Endothelial Cell Adhesion Molecules and Their Relationship to Disease Activity in Takayasu's Arteritis." The Journal of Rheumatology, vol. 35, no. 9, 2008, pp. 1842-5.
Tripathy NK, Chandran V, Garg NK, et al. Soluble endothelial cell adhesion molecules and their relationship to disease activity in Takayasu's arteritis. J Rheumatol. 2008;35(9):1842-5.
Tripathy, N. K., Chandran, V., Garg, N. K., Sinha, N., & Nityanand, S. (2008). Soluble endothelial cell adhesion molecules and their relationship to disease activity in Takayasu's arteritis. The Journal of Rheumatology, 35(9), 1842-5.
Tripathy NK, et al. Soluble Endothelial Cell Adhesion Molecules and Their Relationship to Disease Activity in Takayasu's Arteritis. J Rheumatol. 2008;35(9):1842-5. PubMed PMID: 18597403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble endothelial cell adhesion molecules and their relationship to disease activity in Takayasu's arteritis. AU - Tripathy,Naresh K, AU - Chandran,Vinod, AU - Garg,Naveen K, AU - Sinha,Nakul, AU - Nityanand,Soniya, Y1 - 2008/06/15/ PY - 2008/7/4/pubmed PY - 2008/12/17/medline PY - 2008/7/4/entrez SP - 1842 EP - 5 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 35 IS - 9 N2 - OBJECTIVE: To investigate soluble (s) E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1), and their relationship to disease activity in Takayasu's arteritis (TA). METHODS: Levels of adhesion molecules were measured by enzyme immunoassay in the sera of 35 patients with TA, 17 healthy controls, and 15 patients with 12 months followup. RESULTS: Compared to controls, patients had elevated levels of sE-selectin (54.5 +/- 35.0 vs 36.4 +/- 13.0 ng/ml, p < 0.05), sVCAM-1 (280.9 +/- 267.6 vs 141.2 +/- 76.1 ng/ml, p < 0.05), and sICAM-1 (261.3 +/- 168.1 vs 198.3 +/- 74.3 ng/ml, p < 0.05). Compared to controls, patients with inactive TA also had elevated levels of sE-selectin (67.4 +/- 45.9 vs 36.4 +/- 13.0 ng/ml, p < 0.02), sVCAM-1 (327.6 +/- 327.8 vs 141.2 +/- 76.1 ng/ml, p < 0.02), and sICAM-1 (321.9 +/- 179.5 vs 198.3 +/- 74.3 ng/ml, p < 0.02). There was no difference between active TA and controls. sE-selectin had a trend towards increased levels in inactive versus active TA (67.4 +/- 45.9 vs 44.9 +/- 20.3 ng/ml p = 0.059), but there was no difference in sVCAM-1 and sICAM-1 levels between the groups. No adhesion molecule levels showed a change among followup patients. CONCLUSION: Patients with inactive TA have elevated levels of sE-selectin, sVCAM-1, and sICAM-1 that might indicate persistent vasculopathy in clinically inactive disease. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/18597403/Soluble_endothelial_cell_adhesion_molecules_and_their_relationship_to_disease_activity_in_Takayasu's_arteritis_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=18597403 DB - PRIME DP - Unbound Medicine ER -