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C-type lectin Mermaid inhibits dendritic cell mediated HIV-1 transmission to CD4+ T cells.Virology. 2008 Sep 01; 378(2):323-8.V
Abstract
Dendritic cells (DCs) are important in HIV-1 transmission; DCs capture invading HIV-1 through the interaction of the gp120 oligosaccharides with the C-type lectin DC-SIGN and migrate to the lymphoid tissues where HIV-1 is transmitted to T cells. Thus, the HIV-1 envelope glycoprotein gp120 is an attractive target to prevent interactions with DCs and subsequent viral transmission. Here, we have investigated whether the structural homologue of DC-SIGN, the nematode C-type lectin Mermaid can be used to prevent HIV-1 transmission by DCs. Our data demonstrate that Mermaid interacts with high mannose structures present on HIV-1 gp120 and thereby inhibits HIV-1 binding to DC-SIGN on DCs. Moreover, Mermaid inhibits DC-SIGN-mediated HIV-1 transmission from DC to T cells. We have identified Mermaid as a non-cytotoxic agent that shares the glycan specificity with DC-SIGN and inhibits DC-SIGN-gp120 interaction. The results are important for the anti-HIV-1 microbicide development directed at preventing DC-HIV-1 interactions.
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MeSH
Pub Type(s)
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
18597806
Citation
Nabatov, Alexey A., et al. "C-type Lectin Mermaid Inhibits Dendritic Cell Mediated HIV-1 Transmission to CD4+ T Cells." Virology, vol. 378, no. 2, 2008, pp. 323-8.
Nabatov AA, de Jong MA, de Witte L, et al. C-type lectin Mermaid inhibits dendritic cell mediated HIV-1 transmission to CD4+ T cells. Virology. 2008;378(2):323-8.
Nabatov, A. A., de Jong, M. A., de Witte, L., Bulgheresi, S., & Geijtenbeek, T. B. (2008). C-type lectin Mermaid inhibits dendritic cell mediated HIV-1 transmission to CD4+ T cells. Virology, 378(2), 323-8. https://doi.org/10.1016/j.virol.2008.05.025
Nabatov AA, et al. C-type Lectin Mermaid Inhibits Dendritic Cell Mediated HIV-1 Transmission to CD4+ T Cells. Virology. 2008 Sep 1;378(2):323-8. PubMed PMID: 18597806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - C-type lectin Mermaid inhibits dendritic cell mediated HIV-1 transmission to CD4+ T cells.
AU - Nabatov,Alexey A,
AU - de Jong,Marein A W P,
AU - de Witte,Lot,
AU - Bulgheresi,Silvia,
AU - Geijtenbeek,Teunis B H,
Y1 - 2008/07/01/
PY - 2008/04/04/received
PY - 2008/04/25/revised
PY - 2008/05/22/accepted
PY - 2008/7/4/pubmed
PY - 2008/9/24/medline
PY - 2008/7/4/entrez
SP - 323
EP - 8
JF - Virology
JO - Virology
VL - 378
IS - 2
N2 - Dendritic cells (DCs) are important in HIV-1 transmission; DCs capture invading HIV-1 through the interaction of the gp120 oligosaccharides with the C-type lectin DC-SIGN and migrate to the lymphoid tissues where HIV-1 is transmitted to T cells. Thus, the HIV-1 envelope glycoprotein gp120 is an attractive target to prevent interactions with DCs and subsequent viral transmission. Here, we have investigated whether the structural homologue of DC-SIGN, the nematode C-type lectin Mermaid can be used to prevent HIV-1 transmission by DCs. Our data demonstrate that Mermaid interacts with high mannose structures present on HIV-1 gp120 and thereby inhibits HIV-1 binding to DC-SIGN on DCs. Moreover, Mermaid inhibits DC-SIGN-mediated HIV-1 transmission from DC to T cells. We have identified Mermaid as a non-cytotoxic agent that shares the glycan specificity with DC-SIGN and inhibits DC-SIGN-gp120 interaction. The results are important for the anti-HIV-1 microbicide development directed at preventing DC-HIV-1 interactions.
SN - 1096-0341
UR - https://www.unboundmedicine.com/medline/citation/18597806/C_type_lectin_Mermaid_inhibits_dendritic_cell_mediated_HIV_1_transmission_to_CD4+_T_cells_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(08)00365-6
DB - PRIME
DP - Unbound Medicine
ER -
