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Association between lower urinary tract symptoms and serum levels of sex hormones in men.
Urology. 2008 Sep; 72(3):552-5.U

Abstract

OBJECTIVES

Despite the well-known association between lower urinary tract symptoms (LUTS) and male sexual dysfunction, few data are available that describe the relationship between LUTS and sex hormones. The aim of this study was to investigate a possible association between the severity of LUTS and the serum levels of sex hormones in men.

METHODS

A total of 182 randomly selected men attending our general urology clinic were recruited. All participants completed the International Prostate Symptom Score (IPSS), and their sera were evaluated for serum levels of prostate-specific antigen, total and free testosterone, dehydroepiandrosterone sulfate (DHEA-S), luteinizing hormone, follicle-stimulating hormone, prolactin, and estradiol. Storage symptoms were evaluated by the sum of IPSS questions 2, 4, and 7. Voiding symptoms were evaluated by the sum of IPSS questions 3, 5, and 6. The relationship between the IPSSs and serum hormone levels was determined.

RESULTS

On univariate analysis, the total IPSS was significantly associated with age, DHEA-S, and free testosterone. Storage symptoms were significantly associated with age, DHEA-S, free testosterone, and prostate-specific antigen. Voiding symptoms were significantly associated with age and DHEA-S. On multivariate linear regression analysis, only age was significantly associated with LUTS. However, within the subgroup of men 65-82 years old, DHEA-S was significantly associated with the total IPSS and storage symptoms.

CONCLUSIONS

In our study, the severity of LUTS was not associated with serum levels of sex hormones in men. However, in older men, storage symptoms could be affected by the serum DHEA-S level.

Authors+Show Affiliations

Department of Urology, University of Fukui Faculty of Medical Science, Fukui, Japan. uroym@u-fukui.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18597822

Citation

Miwa, Yoshiji, et al. "Association Between Lower Urinary Tract Symptoms and Serum Levels of Sex Hormones in Men." Urology, vol. 72, no. 3, 2008, pp. 552-5.
Miwa Y, Kaneda T, Yokoyama O. Association between lower urinary tract symptoms and serum levels of sex hormones in men. Urology. 2008;72(3):552-5.
Miwa, Y., Kaneda, T., & Yokoyama, O. (2008). Association between lower urinary tract symptoms and serum levels of sex hormones in men. Urology, 72(3), 552-5. https://doi.org/10.1016/j.urology.2008.04.023
Miwa Y, Kaneda T, Yokoyama O. Association Between Lower Urinary Tract Symptoms and Serum Levels of Sex Hormones in Men. Urology. 2008;72(3):552-5. PubMed PMID: 18597822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between lower urinary tract symptoms and serum levels of sex hormones in men. AU - Miwa,Yoshiji, AU - Kaneda,Taisei, AU - Yokoyama,Osamu, Y1 - 2008/07/02/ PY - 2007/04/08/received PY - 2008/01/18/revised PY - 2008/04/09/accepted PY - 2008/7/4/pubmed PY - 2008/9/26/medline PY - 2008/7/4/entrez SP - 552 EP - 5 JF - Urology JO - Urology VL - 72 IS - 3 N2 - OBJECTIVES: Despite the well-known association between lower urinary tract symptoms (LUTS) and male sexual dysfunction, few data are available that describe the relationship between LUTS and sex hormones. The aim of this study was to investigate a possible association between the severity of LUTS and the serum levels of sex hormones in men. METHODS: A total of 182 randomly selected men attending our general urology clinic were recruited. All participants completed the International Prostate Symptom Score (IPSS), and their sera were evaluated for serum levels of prostate-specific antigen, total and free testosterone, dehydroepiandrosterone sulfate (DHEA-S), luteinizing hormone, follicle-stimulating hormone, prolactin, and estradiol. Storage symptoms were evaluated by the sum of IPSS questions 2, 4, and 7. Voiding symptoms were evaluated by the sum of IPSS questions 3, 5, and 6. The relationship between the IPSSs and serum hormone levels was determined. RESULTS: On univariate analysis, the total IPSS was significantly associated with age, DHEA-S, and free testosterone. Storage symptoms were significantly associated with age, DHEA-S, free testosterone, and prostate-specific antigen. Voiding symptoms were significantly associated with age and DHEA-S. On multivariate linear regression analysis, only age was significantly associated with LUTS. However, within the subgroup of men 65-82 years old, DHEA-S was significantly associated with the total IPSS and storage symptoms. CONCLUSIONS: In our study, the severity of LUTS was not associated with serum levels of sex hormones in men. However, in older men, storage symptoms could be affected by the serum DHEA-S level. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/18597822/Association_between_lower_urinary_tract_symptoms_and_serum_levels_of_sex_hormones_in_men_ DB - PRIME DP - Unbound Medicine ER -