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Antidiabetes and antihypertension potential of commonly consumed carbohydrate sweeteners using in vitro models.
J Med Food. 2008 Jun; 11(2):337-48.JM

Abstract

Commonly consumed carbohydrate sweeteners derived from sugar cane, palm, and corn (syrups) were investigated to determine their potential to inhibit key enzymes relevant to Type 2 diabetes and hypertension based on the total phenolic content and antioxidant activity using in vitro models. Among sugar cane derivatives, brown sugars showed higher antidiabetes potential than white sugars; nevertheless, no angiotensin I-converting enzyme (ACE) inhibition was detected in both sugar classes. Brown sugar from Peru and Mauritius (dark muscovado) had the highest total phenolic content and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, which correlated with a moderate inhibition of yeast alpha-glucosidase without showing a significant effect on porcine pancreatic alpha-amylase activity. In addition, chlorogenic acid quantified by high-performance liquid chromatography was detected in these sugars (128 +/- 6 and 144 +/- 2 microg/g of sample weight, respectively). Date sugar exhibited high alpha-glucosidase, alpha-amylase, and ACE inhibitory activities that correlated with high total phenolic content and antioxidant activity. Neither phenolic compounds or antioxidant activity was detected in corn syrups, indicating that nonphenolic factors may be involved in their significant ability to inhibit alpha-glucosidase, alpha-amylase, and ACE. This study provides a strong biochemical rationale for further in vivo studies and useful information to make better dietary sweetener choices for Type 2 diabetes and hypertension management.

Authors+Show Affiliations

Laboratório de Química, Bioquímica e Biologia Molecular de Alimentos, Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18598178

Citation

Ranilla, Lena Galvez, et al. "Antidiabetes and Antihypertension Potential of Commonly Consumed Carbohydrate Sweeteners Using in Vitro Models." Journal of Medicinal Food, vol. 11, no. 2, 2008, pp. 337-48.
Ranilla LG, Kwon YI, Genovese MI, et al. Antidiabetes and antihypertension potential of commonly consumed carbohydrate sweeteners using in vitro models. J Med Food. 2008;11(2):337-48.
Ranilla, L. G., Kwon, Y. I., Genovese, M. I., Lajolo, F. M., & Shetty, K. (2008). Antidiabetes and antihypertension potential of commonly consumed carbohydrate sweeteners using in vitro models. Journal of Medicinal Food, 11(2), 337-48. https://doi.org/10.1089/jmf.2007.689
Ranilla LG, et al. Antidiabetes and Antihypertension Potential of Commonly Consumed Carbohydrate Sweeteners Using in Vitro Models. J Med Food. 2008;11(2):337-48. PubMed PMID: 18598178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetes and antihypertension potential of commonly consumed carbohydrate sweeteners using in vitro models. AU - Ranilla,Lena Galvez, AU - Kwon,Young-In, AU - Genovese,Maria Ines, AU - Lajolo,Franco Maria, AU - Shetty,Kalidas, PY - 2008/7/5/pubmed PY - 2008/11/11/medline PY - 2008/7/5/entrez SP - 337 EP - 48 JF - Journal of medicinal food JO - J Med Food VL - 11 IS - 2 N2 - Commonly consumed carbohydrate sweeteners derived from sugar cane, palm, and corn (syrups) were investigated to determine their potential to inhibit key enzymes relevant to Type 2 diabetes and hypertension based on the total phenolic content and antioxidant activity using in vitro models. Among sugar cane derivatives, brown sugars showed higher antidiabetes potential than white sugars; nevertheless, no angiotensin I-converting enzyme (ACE) inhibition was detected in both sugar classes. Brown sugar from Peru and Mauritius (dark muscovado) had the highest total phenolic content and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, which correlated with a moderate inhibition of yeast alpha-glucosidase without showing a significant effect on porcine pancreatic alpha-amylase activity. In addition, chlorogenic acid quantified by high-performance liquid chromatography was detected in these sugars (128 +/- 6 and 144 +/- 2 microg/g of sample weight, respectively). Date sugar exhibited high alpha-glucosidase, alpha-amylase, and ACE inhibitory activities that correlated with high total phenolic content and antioxidant activity. Neither phenolic compounds or antioxidant activity was detected in corn syrups, indicating that nonphenolic factors may be involved in their significant ability to inhibit alpha-glucosidase, alpha-amylase, and ACE. This study provides a strong biochemical rationale for further in vivo studies and useful information to make better dietary sweetener choices for Type 2 diabetes and hypertension management. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/18598178/Antidiabetes_and_antihypertension_potential_of_commonly_consumed_carbohydrate_sweeteners_using_in_vitro_models_ L2 - https://www.liebertpub.com/doi/10.1089/jmf.2007.689?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -