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[Effect of apoB polymorphism on plasma lipid levels and cerebral hemorrhage in Changsha Han Chinese].
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Jun; 33(6):494-9.ZN

Abstract

OBJECTIVE

To explore the effect of apoB polymorphism on plasma lipid levels and cerebral hemorrhage in (CH) Changsha Han Chinese.

METHODS

One hundred thirty CH patients and 100 normal people were involved. C7673T polymorphism of apoprotein B was analyzed by PCR-restriction fragment length polymorphism (PCR-PFLP); and the triglyceride(TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL), and low density lipoprotein-cholesterol(LDL) levels were examined by oxidase method. The serum level of lipoprotein(a) was determined by immunology method.

RESULTS

(1) Allele T frequencies of apoB C7673T in CH patients and the control group were 0.108 and 0.040, respectively. Allele T frequencies of apoB C7673T in the CH patients were significantly higher than those in the control group (P< 0.01). (2) In the CH patients, the levels of TC and LDLjC of the T/C gene type were significantly higher than those of the C/C gene type, while the levels of HDLjC of the T/C gene type were significantly lower than those of the C/C gene type (P< 0.05).

CONCLUSION

ApoB C7673T polymorphism may be related to cerebral hemorrhage, and the changing blood lipid level may increase the susceptibility of CH.

Authors+Show Affiliations

Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18599996

Citation

Hu, Zhong-Yang, et al. "[Effect of apoB Polymorphism On Plasma Lipid Levels and Cerebral Hemorrhage in Changsha Han Chinese]." Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, vol. 33, no. 6, 2008, pp. 494-9.
Hu ZY, Zhang L, Yang QD. [Effect of apoB polymorphism on plasma lipid levels and cerebral hemorrhage in Changsha Han Chinese]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008;33(6):494-9.
Hu, Z. Y., Zhang, L., & Yang, Q. D. (2008). [Effect of apoB polymorphism on plasma lipid levels and cerebral hemorrhage in Changsha Han Chinese]. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 33(6), 494-9.
Hu ZY, Zhang L, Yang QD. [Effect of apoB Polymorphism On Plasma Lipid Levels and Cerebral Hemorrhage in Changsha Han Chinese]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008;33(6):494-9. PubMed PMID: 18599996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of apoB polymorphism on plasma lipid levels and cerebral hemorrhage in Changsha Han Chinese]. AU - Hu,Zhong-Yang, AU - Zhang,Le, AU - Yang,Qi-Dong, PY - 2008/7/5/pubmed PY - 2009/5/8/medline PY - 2008/7/5/entrez SP - 494 EP - 9 JF - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JO - Zhong Nan Da Xue Xue Bao Yi Xue Ban VL - 33 IS - 6 N2 - OBJECTIVE: To explore the effect of apoB polymorphism on plasma lipid levels and cerebral hemorrhage in (CH) Changsha Han Chinese. METHODS: One hundred thirty CH patients and 100 normal people were involved. C7673T polymorphism of apoprotein B was analyzed by PCR-restriction fragment length polymorphism (PCR-PFLP); and the triglyceride(TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL), and low density lipoprotein-cholesterol(LDL) levels were examined by oxidase method. The serum level of lipoprotein(a) was determined by immunology method. RESULTS: (1) Allele T frequencies of apoB C7673T in CH patients and the control group were 0.108 and 0.040, respectively. Allele T frequencies of apoB C7673T in the CH patients were significantly higher than those in the control group (P< 0.01). (2) In the CH patients, the levels of TC and LDLjC of the T/C gene type were significantly higher than those of the C/C gene type, while the levels of HDLjC of the T/C gene type were significantly lower than those of the C/C gene type (P< 0.05). CONCLUSION: ApoB C7673T polymorphism may be related to cerebral hemorrhage, and the changing blood lipid level may increase the susceptibility of CH. SN - 1672-7347 UR - https://www.unboundmedicine.com/medline/citation/18599996/[Effect_of_apoB_polymorphism_on_plasma_lipid_levels_and_cerebral_hemorrhage_in_Changsha_Han_Chinese]_ L2 - http://xbyxb.csu.edu.cn/xbwk/fileup/PDF/200806494.pdf DB - PRIME DP - Unbound Medicine ER -