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Headspace sampling and detection of cocaine, MDMA, and marijuana via volatile markers in the presence of potential interferences by solid phase microextraction-ion mobility spectrometry (SPME-IMS).
Anal Bioanal Chem. 2008 Sep; 392(1-2):105-13.AB

Abstract

The successful air sampling and detection of cocaine, methylenedioxymethylamphetamine (MDMA), and marijuana using SPME-IMS achieved by targeting their volatile markers (methyl benzoate, piperonal, and terpenes, respectively) is presented. Conventional methods of direct air sampling for drugs are ineffective because the parent compounds of these drugs have very low vapor pressures, making them unavailable for headspace sampling. Instead of targeting the parent drugs, IMS was set at the optimal operating conditions (determined in previous work) in order to detect their volatile chemical markers. SPME is an effective and rapid air sampling technique for the preconcentration of analytes which is especially useful in confined spaces such as cargo containers, where the volatile marker compounds of drugs can be found in sufficient concentrations. By sampling the air using a 100 microm polydimethyl siloxane (PDMS) SPME fiber for as little as one minute, enough mass of the targeted volatile markers in the headspace of a quart-sized metal paint can (gallon, approximately 1101 cm(3)) which contained sub-gram quantities of the drug samples was recovered for IMS detection. Additionally, several potentially interfering compounds found in goods commonly shipped in cargo containers were tested individually as well as in mixtures with the drugs. No peak interferences were observed for MDMA or marijuana, and minimal peak interferences were found for cocaine.

Authors+Show Affiliations

Department of Chemistry and Biochemistry, International Forensic Research Institute, Florida International University, 11200 SW 8th St. CP 316, Miami, FL 33199, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18600317

Citation

Lai, Hanh, et al. "Headspace Sampling and Detection of Cocaine, MDMA, and Marijuana Via Volatile Markers in the Presence of Potential Interferences By Solid Phase Microextraction-ion Mobility Spectrometry (SPME-IMS)." Analytical and Bioanalytical Chemistry, vol. 392, no. 1-2, 2008, pp. 105-13.
Lai H, Corbin I, Almirall JR. Headspace sampling and detection of cocaine, MDMA, and marijuana via volatile markers in the presence of potential interferences by solid phase microextraction-ion mobility spectrometry (SPME-IMS). Anal Bioanal Chem. 2008;392(1-2):105-13.
Lai, H., Corbin, I., & Almirall, J. R. (2008). Headspace sampling and detection of cocaine, MDMA, and marijuana via volatile markers in the presence of potential interferences by solid phase microextraction-ion mobility spectrometry (SPME-IMS). Analytical and Bioanalytical Chemistry, 392(1-2), 105-13. https://doi.org/10.1007/s00216-008-2229-z
Lai H, Corbin I, Almirall JR. Headspace Sampling and Detection of Cocaine, MDMA, and Marijuana Via Volatile Markers in the Presence of Potential Interferences By Solid Phase Microextraction-ion Mobility Spectrometry (SPME-IMS). Anal Bioanal Chem. 2008;392(1-2):105-13. PubMed PMID: 18600317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Headspace sampling and detection of cocaine, MDMA, and marijuana via volatile markers in the presence of potential interferences by solid phase microextraction-ion mobility spectrometry (SPME-IMS). AU - Lai,Hanh, AU - Corbin,Inge, AU - Almirall,José R, Y1 - 2008/07/05/ PY - 2008/04/26/received PY - 2008/06/02/accepted PY - 2008/05/31/revised PY - 2008/7/5/pubmed PY - 2008/9/27/medline PY - 2008/7/5/entrez SP - 105 EP - 13 JF - Analytical and bioanalytical chemistry JO - Anal Bioanal Chem VL - 392 IS - 1-2 N2 - The successful air sampling and detection of cocaine, methylenedioxymethylamphetamine (MDMA), and marijuana using SPME-IMS achieved by targeting their volatile markers (methyl benzoate, piperonal, and terpenes, respectively) is presented. Conventional methods of direct air sampling for drugs are ineffective because the parent compounds of these drugs have very low vapor pressures, making them unavailable for headspace sampling. Instead of targeting the parent drugs, IMS was set at the optimal operating conditions (determined in previous work) in order to detect their volatile chemical markers. SPME is an effective and rapid air sampling technique for the preconcentration of analytes which is especially useful in confined spaces such as cargo containers, where the volatile marker compounds of drugs can be found in sufficient concentrations. By sampling the air using a 100 microm polydimethyl siloxane (PDMS) SPME fiber for as little as one minute, enough mass of the targeted volatile markers in the headspace of a quart-sized metal paint can (gallon, approximately 1101 cm(3)) which contained sub-gram quantities of the drug samples was recovered for IMS detection. Additionally, several potentially interfering compounds found in goods commonly shipped in cargo containers were tested individually as well as in mixtures with the drugs. No peak interferences were observed for MDMA or marijuana, and minimal peak interferences were found for cocaine. SN - 1618-2650 UR - https://www.unboundmedicine.com/medline/citation/18600317/Headspace_sampling_and_detection_of_cocaine_MDMA_and_marijuana_via_volatile_markers_in_the_presence_of_potential_interferences_by_solid_phase_microextraction_ion_mobility_spectrometry__SPME_IMS__ L2 - https://dx.doi.org/10.1007/s00216-008-2229-z DB - PRIME DP - Unbound Medicine ER -