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Host-microbe interactions: innate pattern recognition of fungal pathogens.
Curr Opin Microbiol. 2008 Aug; 11(4):305-12.CO

Abstract

The recognition of fungi is mediated by germline pattern recognition receptors (PRRs) such as Toll-like receptors and lectin receptors that interact with conserved structures of the microorganisms, the pathogen-associated molecular patterns (PAMPs). Subsequently, PRRs activate intracellular signals that collaborate for the efficient activation of the host defense. The specificity of these responses is achieved through the activation of a particular mosaic of PRRs, that is determined by the available fungal PAMPs and the innate immune cells involved. This will determine a divergence of the final type of reaction, and in this way the innate host defense has the capability to deliver tailored responses to each pathogen.

Authors+Show Affiliations

Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18602019

Citation

van de Veerdonk, Frank L., et al. "Host-microbe Interactions: Innate Pattern Recognition of Fungal Pathogens." Current Opinion in Microbiology, vol. 11, no. 4, 2008, pp. 305-12.
van de Veerdonk FL, Kullberg BJ, van der Meer JW, et al. Host-microbe interactions: innate pattern recognition of fungal pathogens. Curr Opin Microbiol. 2008;11(4):305-12.
van de Veerdonk, F. L., Kullberg, B. J., van der Meer, J. W., Gow, N. A., & Netea, M. G. (2008). Host-microbe interactions: innate pattern recognition of fungal pathogens. Current Opinion in Microbiology, 11(4), 305-12. https://doi.org/10.1016/j.mib.2008.06.002
van de Veerdonk FL, et al. Host-microbe Interactions: Innate Pattern Recognition of Fungal Pathogens. Curr Opin Microbiol. 2008;11(4):305-12. PubMed PMID: 18602019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Host-microbe interactions: innate pattern recognition of fungal pathogens. AU - van de Veerdonk,Frank L, AU - Kullberg,Bart Jan, AU - van der Meer,Jos W M, AU - Gow,Neil A R, AU - Netea,Mihai G, Y1 - 2008/07/17/ PY - 2008/05/05/received PY - 2008/05/22/revised PY - 2008/06/02/accepted PY - 2008/7/8/pubmed PY - 2008/10/22/medline PY - 2008/7/8/entrez SP - 305 EP - 12 JF - Current opinion in microbiology JO - Curr. Opin. Microbiol. VL - 11 IS - 4 N2 - The recognition of fungi is mediated by germline pattern recognition receptors (PRRs) such as Toll-like receptors and lectin receptors that interact with conserved structures of the microorganisms, the pathogen-associated molecular patterns (PAMPs). Subsequently, PRRs activate intracellular signals that collaborate for the efficient activation of the host defense. The specificity of these responses is achieved through the activation of a particular mosaic of PRRs, that is determined by the available fungal PAMPs and the innate immune cells involved. This will determine a divergence of the final type of reaction, and in this way the innate host defense has the capability to deliver tailored responses to each pathogen. SN - 1369-5274 UR - https://www.unboundmedicine.com/medline/citation/18602019/Host_microbe_interactions:_innate_pattern_recognition_of_fungal_pathogens_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1369-5274(08)00074-X DB - PRIME DP - Unbound Medicine ER -