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Effects of milrinone on left ventricular remodeling after acute myocardial infarction.
Circulation. 1991 Aug; 84(2):796-804.Circ

Abstract

BACKGROUND

Left ventricular remodeling after an acute myocardial infarction may result in progressive left ventricular dilation that may be associated with increased mortality. We studied the effects of the phosphodiesterase inhibitor milrinone on left ventricular remodeling after acute myocardial infarction.

METHODS AND RESULTS

Rats (n = 90) were randomized to undergo either left coronary artery ligation or sham operation. Three weeks after surgery, rats received either no treatment or milrinone, which was continued until 2 days before the rats were killed. Ninety days after the initial surgery, hemodynamic measurements were made before and after volume loading. The rats were killed, the hearts were removed, and passive pressure-volume curves were obtained. The hearts were fixed at a constant pressure and analyzed morphometrically. Compared with untreated infarcted rats, milrinone-treated infarcted rats had a lower left ventricular end-diastolic pressure (1.7 +/- 0.4 versus 4.3 +/- 1.4 mm Hg, p less than 0.05), a lower left ventricular volume (1.25 +/- 0.20 versus 2.37 +/- 0.30 ml/kg, p less than 0.001) and a lower left ventricular wall stress index (1.3 +/- 0.2 versus 1.7 +/- 0.1, p less than 0.05). Left ventricular chamber stiffness was higher in milrinone-treated infarcted rats than in untreated infarcted rats. Milrinone had no cardiac effect on uninfarcted animals.

CONCLUSION

Chronic milrinone therapy after acute myocardial infarction improves cardiac hemodynamic indexes and attenuates progressive left ventricular dilation.

Authors+Show Affiliations

Department of Medicine, State University of New York, Stony Brook 11794-8171.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1860222

Citation

Jain, P, et al. "Effects of Milrinone On Left Ventricular Remodeling After Acute Myocardial Infarction." Circulation, vol. 84, no. 2, 1991, pp. 796-804.
Jain P, Brown EJ, Langenback EG, et al. Effects of milrinone on left ventricular remodeling after acute myocardial infarction. Circulation. 1991;84(2):796-804.
Jain, P., Brown, E. J., Langenback, E. G., Raeder, E., Lillis, O., Halpern, J., & Mannisi, J. A. (1991). Effects of milrinone on left ventricular remodeling after acute myocardial infarction. Circulation, 84(2), 796-804.
Jain P, et al. Effects of Milrinone On Left Ventricular Remodeling After Acute Myocardial Infarction. Circulation. 1991;84(2):796-804. PubMed PMID: 1860222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of milrinone on left ventricular remodeling after acute myocardial infarction. AU - Jain,P, AU - Brown,E J,Jr AU - Langenback,E G, AU - Raeder,E, AU - Lillis,O, AU - Halpern,J, AU - Mannisi,J A, PY - 1991/8/11/pubmed PY - 2001/3/28/medline PY - 1991/8/11/entrez SP - 796 EP - 804 JF - Circulation JO - Circulation VL - 84 IS - 2 N2 - BACKGROUND: Left ventricular remodeling after an acute myocardial infarction may result in progressive left ventricular dilation that may be associated with increased mortality. We studied the effects of the phosphodiesterase inhibitor milrinone on left ventricular remodeling after acute myocardial infarction. METHODS AND RESULTS: Rats (n = 90) were randomized to undergo either left coronary artery ligation or sham operation. Three weeks after surgery, rats received either no treatment or milrinone, which was continued until 2 days before the rats were killed. Ninety days after the initial surgery, hemodynamic measurements were made before and after volume loading. The rats were killed, the hearts were removed, and passive pressure-volume curves were obtained. The hearts were fixed at a constant pressure and analyzed morphometrically. Compared with untreated infarcted rats, milrinone-treated infarcted rats had a lower left ventricular end-diastolic pressure (1.7 +/- 0.4 versus 4.3 +/- 1.4 mm Hg, p less than 0.05), a lower left ventricular volume (1.25 +/- 0.20 versus 2.37 +/- 0.30 ml/kg, p less than 0.001) and a lower left ventricular wall stress index (1.3 +/- 0.2 versus 1.7 +/- 0.1, p less than 0.05). Left ventricular chamber stiffness was higher in milrinone-treated infarcted rats than in untreated infarcted rats. Milrinone had no cardiac effect on uninfarcted animals. CONCLUSION: Chronic milrinone therapy after acute myocardial infarction improves cardiac hemodynamic indexes and attenuates progressive left ventricular dilation. SN - 0009-7322 UR - https://www.unboundmedicine.com/medline/citation/1860222/Effects_of_milrinone_on_left_ventricular_remodeling_after_acute_myocardial_infarction_ L2 - https://www.ahajournals.org/doi/10.1161/01.cir.84.2.796?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -