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The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats.
Behav Brain Res. 2008 Nov 21; 193(2):298-305.BB

Abstract

Cannabinoid CB1 inverse agonists such as rimonabant and AM 251 hold therapeutic promise as appetite suppressants, but the extent to which non-motivational factors contribute to their anorectic effects is not fully known. Examination of the behavioral satiety sequence (BSS) in rats, the orderly progression from eating to post-prandial grooming and then resting, has revealed that these compounds preserve the order of events but differ markedly from natural satiation. The most notable difference is that grooming (particularly scratching) is profoundly enhanced at anorectic doses, while eating and resting are diminished, raising the possibility that the anorectic effect is simply secondary to the grooming effect. In the current design, the neutral CB1 antagonist AM 4113, which has been found to lack some of the undesirable effects of AM 251, produced nearly identical effects on the BSS as AM 251. The possibility that competition from enhanced grooming could account for the anorectic effect of AM 4113 was examined by yoking the pattern of disruptions caused by grooming in the AM 4113-treated group to forced locomotion in a different group fed in a modified running wheel. This response competition did not significantly reduce food intake. It was concluded that AM 4113, a CB1 neutral antagonist, produces the same effects on the BSS as AM 251, but that response competition from enhanced grooming may not be a sufficient explanation for the anorectic effects of CB1 antagonists/inverse agonists.

Authors+Show Affiliations

Department of Psychology, Edinboro University of Pennsylvania, 210 East Normal Street, Edinboro, PA 16444, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18602425

Citation

Hodge, Janel, et al. "The Cannabinoid CB1 Receptor Inverse Agonist AM 251 and Antagonist AM 4113 Produce Similar Effects On the Behavioral Satiety Sequence in Rats." Behavioural Brain Research, vol. 193, no. 2, 2008, pp. 298-305.
Hodge J, Bow JP, Plyler KS, et al. The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats. Behav Brain Res. 2008;193(2):298-305.
Hodge, J., Bow, J. P., Plyler, K. S., Vemuri, V. K., Wisniecki, A., Salamone, J. D., Makriyannis, A., & McLaughlin, P. J. (2008). The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats. Behavioural Brain Research, 193(2), 298-305. https://doi.org/10.1016/j.bbr.2008.06.010
Hodge J, et al. The Cannabinoid CB1 Receptor Inverse Agonist AM 251 and Antagonist AM 4113 Produce Similar Effects On the Behavioral Satiety Sequence in Rats. Behav Brain Res. 2008 Nov 21;193(2):298-305. PubMed PMID: 18602425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats. AU - Hodge,Janel, AU - Bow,Joshua P, AU - Plyler,Kimberly S, AU - Vemuri,V Kiran, AU - Wisniecki,Ania, AU - Salamone,John D, AU - Makriyannis,Alexandros, AU - McLaughlin,Peter J, Y1 - 2008/06/17/ PY - 2008/03/06/received PY - 2008/06/04/revised PY - 2008/06/10/accepted PY - 2008/7/8/pubmed PY - 2008/11/4/medline PY - 2008/7/8/entrez SP - 298 EP - 305 JF - Behavioural brain research JO - Behav Brain Res VL - 193 IS - 2 N2 - Cannabinoid CB1 inverse agonists such as rimonabant and AM 251 hold therapeutic promise as appetite suppressants, but the extent to which non-motivational factors contribute to their anorectic effects is not fully known. Examination of the behavioral satiety sequence (BSS) in rats, the orderly progression from eating to post-prandial grooming and then resting, has revealed that these compounds preserve the order of events but differ markedly from natural satiation. The most notable difference is that grooming (particularly scratching) is profoundly enhanced at anorectic doses, while eating and resting are diminished, raising the possibility that the anorectic effect is simply secondary to the grooming effect. In the current design, the neutral CB1 antagonist AM 4113, which has been found to lack some of the undesirable effects of AM 251, produced nearly identical effects on the BSS as AM 251. The possibility that competition from enhanced grooming could account for the anorectic effect of AM 4113 was examined by yoking the pattern of disruptions caused by grooming in the AM 4113-treated group to forced locomotion in a different group fed in a modified running wheel. This response competition did not significantly reduce food intake. It was concluded that AM 4113, a CB1 neutral antagonist, produces the same effects on the BSS as AM 251, but that response competition from enhanced grooming may not be a sufficient explanation for the anorectic effects of CB1 antagonists/inverse agonists. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/18602425/The_cannabinoid_CB1_receptor_inverse_agonist_AM_251_and_antagonist_AM_4113_produce_similar_effects_on_the_behavioral_satiety_sequence_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(08)00312-4 DB - PRIME DP - Unbound Medicine ER -