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Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults.

Abstract

The objective of this investigation was to examine the pharmacokinetics of isoflavone concentrations over a 24-h period among healthy adults consuming either soy foods or soy isoflavone tablets at different doses. This randomized, cross-over trial was conducted with 12 generally healthy adults. The three phases of the intervention included isoflavone tablets at (1) 144 mg/day or (2) 288 mg/day and (3) soy foods designed to provide a calculated 96 mg isoflavones/day (doses in aglycone equivalents). Doses were spread out over three meals per day. After 6 days on each study phase, plasma isoflavone concentrations were determined on the seventh day at 0, 4, 8, 10, 12 and 24 h. Average levels of total isoflavone concentrations at 8, 10 and 12 h were >4 micromol/L for the soy food phase and for the higher dose tablet phase. Genistein concentrations were higher overall in the soy food vs. both the lower and the higher dose supplement phases of the study (P<.05). When comparing plasma concentrations for the two doses of tablets, saturation appeared more evident for genistein than for daidzein at the higher dose level. In conclusion, we observed important differences in the pharmacokinetics of genistein and daidzein contrasting the sources and doses of isoflavones when administered three times daily, including a possible advantage for increasing serum concentrations of isoflavones from consuming soy foods relative to isoflavone supplements.

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  • Authors+Show Affiliations

    ,

    Stanford Prevention Research Center, Stanford University Medical School, CA 94305-5705, USA. cgardner@stanford.edu

    ,

    Source

    MeSH

    Adult
    Aged
    Biological Availability
    Blood Specimen Collection
    Dietary Supplements
    Female
    Genistein
    Humans
    Isoflavones
    Middle Aged
    Soy Foods

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    18602820

    Citation

    Gardner, Christopher D., et al. "Effects of Isoflavone Supplements Vs. Soy Foods On Blood Concentrations of Genistein and Daidzein in Adults." The Journal of Nutritional Biochemistry, vol. 20, no. 3, 2009, pp. 227-34.
    Gardner CD, Chatterjee LM, Franke AA. Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults. J Nutr Biochem. 2009;20(3):227-34.
    Gardner, C. D., Chatterjee, L. M., & Franke, A. A. (2009). Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults. The Journal of Nutritional Biochemistry, 20(3), pp. 227-34. doi:10.1016/j.jnutbio.2008.02.008.
    Gardner CD, Chatterjee LM, Franke AA. Effects of Isoflavone Supplements Vs. Soy Foods On Blood Concentrations of Genistein and Daidzein in Adults. J Nutr Biochem. 2009;20(3):227-34. PubMed PMID: 18602820.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults. AU - Gardner,Christopher D, AU - Chatterjee,Lorraine M, AU - Franke,Adrian A, Y1 - 2008/07/07/ PY - 2007/09/17/received PY - 2008/02/15/revised PY - 2008/02/20/accepted PY - 2008/7/8/pubmed PY - 2009/3/27/medline PY - 2008/7/8/entrez SP - 227 EP - 34 JF - The Journal of nutritional biochemistry JO - J. Nutr. Biochem. VL - 20 IS - 3 N2 - The objective of this investigation was to examine the pharmacokinetics of isoflavone concentrations over a 24-h period among healthy adults consuming either soy foods or soy isoflavone tablets at different doses. This randomized, cross-over trial was conducted with 12 generally healthy adults. The three phases of the intervention included isoflavone tablets at (1) 144 mg/day or (2) 288 mg/day and (3) soy foods designed to provide a calculated 96 mg isoflavones/day (doses in aglycone equivalents). Doses were spread out over three meals per day. After 6 days on each study phase, plasma isoflavone concentrations were determined on the seventh day at 0, 4, 8, 10, 12 and 24 h. Average levels of total isoflavone concentrations at 8, 10 and 12 h were >4 micromol/L for the soy food phase and for the higher dose tablet phase. Genistein concentrations were higher overall in the soy food vs. both the lower and the higher dose supplement phases of the study (P<.05). When comparing plasma concentrations for the two doses of tablets, saturation appeared more evident for genistein than for daidzein at the higher dose level. In conclusion, we observed important differences in the pharmacokinetics of genistein and daidzein contrasting the sources and doses of isoflavones when administered three times daily, including a possible advantage for increasing serum concentrations of isoflavones from consuming soy foods relative to isoflavone supplements. SN - 0955-2863 UR - https://www.unboundmedicine.com/medline/citation/18602820/Effects_of_isoflavone_supplements_vs__soy_foods_on_blood_concentrations_of_genistein_and_daidzein_in_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(08)00076-4 DB - PRIME DP - Unbound Medicine ER -