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Mutagenic and antimutagenic properties of extracts from South African traditional medicinal plants.
J Ethnopharmacol. 2008 Oct 28; 119(3):575-87.JE

Abstract

AIM OF THE STUDY

The aim of this paper was to summarize the results of our investigations on the in vitro genotoxic as well as antigenotoxic effects of a great number of selected South African traditional medicinal plants.

MATERIALS AND METHODS

Investigations of methanol and dichloromethane extracts of selected plants were conducted with the bacterial Ames, Umu-C and VITOTOX tests, and with the cytochalasin B micronucleus test and alkaline comet assay in human white blood cells.

RESULTS

A number of extracts were found to have genotoxic properties. Amongst the genotoxic plant extracts, especially methanol extracts of Helichrysum simillimum DC. (Asteraceae) should be highlighted. On the other hand, some plant extracts also showed antimutagenic potential. Here Bauhinia galpinii N.E.Br. (Fabaceae) and especially Chlerodendrum myricoides (Hochst.) Vatke (=Rotheca myricoides (Hochst.) Steane & Mabb.; Lamiaceae) appear to have antimutagenic properties.

CONCLUSION

The safe use of Helichrysum similimum should be questioned and further investigations on its mutagenicity and overall biological properties should be encouraged. Antimutagenic properties of especially Bauhinia galpinii and Rotheca myricoides are considered of particular interest as it may be assumed that these antimutagenic natural substances are able to lower the cancer risk from everyday exposures to environmental mutagens as well as to mutagenic pharmaceuticals.

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Authors+Show Affiliations

Verschaeve L
Scientific Institute of Public Health, Department of Epidemiology and Toxicology, J. Wytsmanstreet 14, B-1050 Brussels, Belgium. luc.verschaeve@iph.fgov.be
Van Staden J
No affiliation info available

MeSH

Antimutagenic AgentsChromatography, LiquidChromatography, Thin LayerComet AssayHumansIn Vitro TechniquesLeukocytesMedicine, African TraditionalMicronucleus TestsMutagenicity TestsMutagensPlant ExtractsPlants, MedicinalSouth Africa

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18602977

Citation

Verschaeve, L, and J Van Staden. "Mutagenic and Antimutagenic Properties of Extracts From South African Traditional Medicinal Plants." Journal of Ethnopharmacology, vol. 119, no. 3, 2008, pp. 575-87.
Verschaeve L, Van Staden J. Mutagenic and antimutagenic properties of extracts from South African traditional medicinal plants. J Ethnopharmacol. 2008;119(3):575-87.
Verschaeve, L., & Van Staden, J. (2008). Mutagenic and antimutagenic properties of extracts from South African traditional medicinal plants. Journal of Ethnopharmacology, 119(3), 575-87. https://doi.org/10.1016/j.jep.2008.06.007
Verschaeve L, Van Staden J. Mutagenic and Antimutagenic Properties of Extracts From South African Traditional Medicinal Plants. J Ethnopharmacol. 2008 Oct 28;119(3):575-87. PubMed PMID: 18602977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mutagenic and antimutagenic properties of extracts from South African traditional medicinal plants. AU - Verschaeve,L, AU - Van Staden,J, Y1 - 2008/06/18/ PY - 2008/03/19/received PY - 2008/06/02/revised PY - 2008/06/09/accepted PY - 2008/7/8/pubmed PY - 2009/1/24/medline PY - 2008/7/8/entrez SP - 575 EP - 87 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 119 IS - 3 N2 - AIM OF THE STUDY: The aim of this paper was to summarize the results of our investigations on the in vitro genotoxic as well as antigenotoxic effects of a great number of selected South African traditional medicinal plants. MATERIALS AND METHODS: Investigations of methanol and dichloromethane extracts of selected plants were conducted with the bacterial Ames, Umu-C and VITOTOX tests, and with the cytochalasin B micronucleus test and alkaline comet assay in human white blood cells. RESULTS: A number of extracts were found to have genotoxic properties. Amongst the genotoxic plant extracts, especially methanol extracts of Helichrysum simillimum DC. (Asteraceae) should be highlighted. On the other hand, some plant extracts also showed antimutagenic potential. Here Bauhinia galpinii N.E.Br. (Fabaceae) and especially Chlerodendrum myricoides (Hochst.) Vatke (=Rotheca myricoides (Hochst.) Steane & Mabb.; Lamiaceae) appear to have antimutagenic properties. CONCLUSION: The safe use of Helichrysum similimum should be questioned and further investigations on its mutagenicity and overall biological properties should be encouraged. Antimutagenic properties of especially Bauhinia galpinii and Rotheca myricoides are considered of particular interest as it may be assumed that these antimutagenic natural substances are able to lower the cancer risk from everyday exposures to environmental mutagens as well as to mutagenic pharmaceuticals. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18602977/Mutagenic_and_antimutagenic_properties_of_extracts_from_South_African_traditional_medicinal_plants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00305-X DB - PRIME DP - Unbound Medicine ER -