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Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis.
Int J Gynaecol Obstet. 2008 Sep; 102(3):287-92.IJ

Abstract

OBJECTIVE

To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis.

METHODS

Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment.

RESULTS

Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7%, while the cure rates according to microscopy and Candida albicans culture were 81.8% and 73.9%, respectively. The cure rate for bacterial vaginosis was 75% and culture of Gardnerella vaginalis turned negative in 63.6% of cases following treatment. The medication was well tolerated.

CONCLUSION

Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis.

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Publisher Full Text

Authors+Show Affiliations

Peixoto F
Laboratory of Human Reproduction, Teaching Hospital, Federal University of Minas Gerais, Brazil. fabiocpeixoto@terra.com.br
Camargos A
No affiliation info available
Duarte G
No affiliation info available
Linhares I
No affiliation info available
Bahamondes L
No affiliation info available
Petracco A
No affiliation info available

MeSH

Administration, IntravaginalAdolescentAdultAntifungal AgentsCandidiasis, VulvovaginalDrug Therapy, CombinationFemaleGardnerella vaginalisHumansMetronidazoleMiconazoleMiddle AgedPessariesTrichomonas Vaginitis

Pub Type(s)

Clinical Trial, Phase III
Journal Article
Multicenter Study

Language

eng

PubMed ID

18603245

Citation

Peixoto, Fabio, et al. "Efficacy and Tolerance of Metronidazole and Miconazole Nitrate in Treatment of Vaginitis." International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, vol. 102, no. 3, 2008, pp. 287-92.
Peixoto F, Camargos A, Duarte G, et al. Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis. Int J Gynaecol Obstet. 2008;102(3):287-92.
Peixoto, F., Camargos, A., Duarte, G., Linhares, I., Bahamondes, L., & Petracco, A. (2008). Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, 102(3), 287-92. https://doi.org/10.1016/j.ijgo.2008.04.014
Peixoto F, et al. Efficacy and Tolerance of Metronidazole and Miconazole Nitrate in Treatment of Vaginitis. Int J Gynaecol Obstet. 2008;102(3):287-92. PubMed PMID: 18603245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis. AU - Peixoto,Fabio, AU - Camargos,Aroldo, AU - Duarte,Geraldo, AU - Linhares,Iara, AU - Bahamondes,Luis, AU - Petracco,Alvaro, Y1 - 2008/07/07/ PY - 2007/12/12/received PY - 2008/04/09/revised PY - 2008/04/10/accepted PY - 2008/7/8/pubmed PY - 2008/12/17/medline PY - 2008/7/8/entrez SP - 287 EP - 92 JF - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JO - Int J Gynaecol Obstet VL - 102 IS - 3 N2 - OBJECTIVE: To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis. METHODS: Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment. RESULTS: Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7%, while the cure rates according to microscopy and Candida albicans culture were 81.8% and 73.9%, respectively. The cure rate for bacterial vaginosis was 75% and culture of Gardnerella vaginalis turned negative in 63.6% of cases following treatment. The medication was well tolerated. CONCLUSION: Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis. SN - 0020-7292 UR - https://www.unboundmedicine.com/medline/citation/18603245/Efficacy_and_tolerance_of_metronidazole_and_miconazole_nitrate_in_treatment_of_vaginitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0020-7292(08)00197-5 DB - PRIME DP - Unbound Medicine ER -