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A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation.
J Am Acad Dermatol. 2008 Sep; 59(3):418-25.JA

Abstract

BACKGROUND

Skin cancer and photoaging changes result from ultraviolet (UV)-induced oxidative stress. Topical antioxidants may protect skin from these effects.

OBJECTIVE

We sought to determine whether a stable topical formulation of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid (CEFer) could protect human skin in vivo from substantial amounts of solar-simulated UV radiation.

METHODS

CEFer and its vehicle were applied to separate patches of normal-appearing human skin for 4 days. Each patch was irradiated with solar-simulated UV, 2 to 10 minimal erythema doses, at 2-minimal erythema dose intervals. One day later, skin was evaluated for erythema and sunburn cells, and immunohistochemically for thymine dimers and p53. UV-induced cytokine formation, including interleukin (IL)-1alpha, IL-6, IL-8, and IL-10, and tumor necrosis factor-alpha, were evaluated by real-time polymerase chain reaction.

RESULTS

CEFer provided significant and meaningful photoprotection for skin by all methods of evaluation.

LIMITATIONS

The number of patients evaluated was relatively small.

CONCLUSION

CEFer provided substantial UV photoprotection for skin. It is particularly effective for reducing thymine dimer mutations known to be associated with skin cancer. Its mechanism of action is different from sunscreens and would be expected to supplement the sun protection provided by sunscreens.

Authors+Show Affiliations

Division of Dermatology, Duke University Medical Center, Durham, North Carolina 27710, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18603326

Citation

Murray, John C., et al. "A Topical Antioxidant Solution Containing Vitamins C and E Stabilized By Ferulic Acid Provides Protection for Human Skin Against Damage Caused By Ultraviolet Irradiation." Journal of the American Academy of Dermatology, vol. 59, no. 3, 2008, pp. 418-25.
Murray JC, Burch JA, Streilein RD, et al. A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. J Am Acad Dermatol. 2008;59(3):418-25.
Murray, J. C., Burch, J. A., Streilein, R. D., Iannacchione, M. A., Hall, R. P., & Pinnell, S. R. (2008). A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. Journal of the American Academy of Dermatology, 59(3), 418-25. https://doi.org/10.1016/j.jaad.2008.05.004
Murray JC, et al. A Topical Antioxidant Solution Containing Vitamins C and E Stabilized By Ferulic Acid Provides Protection for Human Skin Against Damage Caused By Ultraviolet Irradiation. J Am Acad Dermatol. 2008;59(3):418-25. PubMed PMID: 18603326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. AU - Murray,John C, AU - Burch,James A, AU - Streilein,Robert D, AU - Iannacchione,Mary Ann, AU - Hall,Russell P, AU - Pinnell,Sheldon R, Y1 - 2008/07/07/ PY - 2008/03/21/received PY - 2008/05/07/revised PY - 2008/05/07/accepted PY - 2008/7/8/pubmed PY - 2008/9/5/medline PY - 2008/7/8/entrez SP - 418 EP - 25 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 59 IS - 3 N2 - BACKGROUND: Skin cancer and photoaging changes result from ultraviolet (UV)-induced oxidative stress. Topical antioxidants may protect skin from these effects. OBJECTIVE: We sought to determine whether a stable topical formulation of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid (CEFer) could protect human skin in vivo from substantial amounts of solar-simulated UV radiation. METHODS: CEFer and its vehicle were applied to separate patches of normal-appearing human skin for 4 days. Each patch was irradiated with solar-simulated UV, 2 to 10 minimal erythema doses, at 2-minimal erythema dose intervals. One day later, skin was evaluated for erythema and sunburn cells, and immunohistochemically for thymine dimers and p53. UV-induced cytokine formation, including interleukin (IL)-1alpha, IL-6, IL-8, and IL-10, and tumor necrosis factor-alpha, were evaluated by real-time polymerase chain reaction. RESULTS: CEFer provided significant and meaningful photoprotection for skin by all methods of evaluation. LIMITATIONS: The number of patients evaluated was relatively small. CONCLUSION: CEFer provided substantial UV photoprotection for skin. It is particularly effective for reducing thymine dimer mutations known to be associated with skin cancer. Its mechanism of action is different from sunscreens and would be expected to supplement the sun protection provided by sunscreens. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/18603326/A_topical_antioxidant_solution_containing_vitamins_C_and_E_stabilized_by_ferulic_acid_provides_protection_for_human_skin_against_damage_caused_by_ultraviolet_irradiation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(08)00541-0 DB - PRIME DP - Unbound Medicine ER -