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Oxidative stress and antioxidant status in cardiovascular diseases in population of western Nepal.
Kathmandu Univ Med J (KUMJ). 2006 Jul-Sep; 4(3):271-4.KU

Abstract

OBJECTIVES

To observe if there is any connectivity between oxidative stress and cardiovascular diseases (CVDs).

MATERIALS AND METHODS

Patients suffering from different cardiovascular diseases (hypertension, ischemic heart disease, rheumatic heart disease) attending Manipal Teaching Hospital, Pokhara and strictly matched controls were selected for this study. Oxidative stress (OS) was measured by plasma thiobarbituric acid reacting substances (TBARS) where as antioxidant status was measured by estimating vitamin E, vitamin C and total antioxidant activity (TAA) in plasma.

RESULTS

The mean level of TBARS, TAA, vitamin C and E were 2.20+0.43 nmol/ml, 547+98 mol/l, 0.88+0.15 mg/dl and 0.75+0.20 mg/dl respectively in patients. The respective values in controls were 1.86+0.43 nmol/ml, 859+139 mol/l, 0.94+0.15 mg/dl and 1.10+0.30 mg/dl. Although the OS seems to be raised in patients, is practically insufficient to oxidize biomolecules and induce CVDs. Despite vitamin C and E levels being well within normal limits, the TAA was significantly and considerably lower in patients. This is a highly interesting observation suggesting that dietary antioxidants other than these vitamins were preferentially consumed to control OS because procedure for TAA used in this study practically measures only total dietary antioxidants.

CONCLUSION

OS does not appear to be an etiological factor for the cardiovascular diseases; rather slightly raised OS in patients seems to be a consequence. Further the raised OS was not due to lower nutrient antioxidant (vit. C and vit. E) in the local population studied herein.

Authors+Show Affiliations

Risal S
Department of Biochemistry, Nepal Medical College, Attarkhel, Jorpati, Kathmandu, Nepal. srisall@hotmail.com
Adhikari D
No affiliation info available
Alurkar VM
No affiliation info available
Singh PP
No affiliation info available

MeSH

AdultAntioxidantsAscorbic AcidCase-Control StudiesCausalityChi-Square DistributionFemaleFree RadicalsHospitals, TeachingHumansHypertensionMaleMiddle AgedMyocardial IschemiaNepalOxidative StressRheumatic Heart DiseaseSmokingThiobarbituric Acid Reactive SubstancesVitamin A DeficiencyVitamin EVitamin E Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18603918

Citation

Risal, S, et al. "Oxidative Stress and Antioxidant Status in Cardiovascular Diseases in Population of Western Nepal." Kathmandu University Medical Journal (KUMJ), vol. 4, no. 3, 2006, pp. 271-4.
Risal S, Adhikari D, Alurkar VM, et al. Oxidative stress and antioxidant status in cardiovascular diseases in population of western Nepal. Kathmandu Univ Med J (KUMJ). 2006;4(3):271-4.
Risal, S., Adhikari, D., Alurkar, V. M., & Singh, P. P. (2006). Oxidative stress and antioxidant status in cardiovascular diseases in population of western Nepal. Kathmandu University Medical Journal (KUMJ), 4(3), 271-4.
Risal S, et al. Oxidative Stress and Antioxidant Status in Cardiovascular Diseases in Population of Western Nepal. Kathmandu Univ Med J (KUMJ). 2006 Jul-Sep;4(3):271-4. PubMed PMID: 18603918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and antioxidant status in cardiovascular diseases in population of western Nepal. AU - Risal,S, AU - Adhikari,D, AU - Alurkar,V M, AU - Singh,P P, PY - 2008/7/8/pubmed PY - 2008/12/17/medline PY - 2008/7/8/entrez SP - 271 EP - 4 JF - Kathmandu University medical journal (KUMJ) JO - Kathmandu Univ Med J (KUMJ) VL - 4 IS - 3 N2 - OBJECTIVES: To observe if there is any connectivity between oxidative stress and cardiovascular diseases (CVDs). MATERIALS AND METHODS: Patients suffering from different cardiovascular diseases (hypertension, ischemic heart disease, rheumatic heart disease) attending Manipal Teaching Hospital, Pokhara and strictly matched controls were selected for this study. Oxidative stress (OS) was measured by plasma thiobarbituric acid reacting substances (TBARS) where as antioxidant status was measured by estimating vitamin E, vitamin C and total antioxidant activity (TAA) in plasma. RESULTS: The mean level of TBARS, TAA, vitamin C and E were 2.20+0.43 nmol/ml, 547+98 mol/l, 0.88+0.15 mg/dl and 0.75+0.20 mg/dl respectively in patients. The respective values in controls were 1.86+0.43 nmol/ml, 859+139 mol/l, 0.94+0.15 mg/dl and 1.10+0.30 mg/dl. Although the OS seems to be raised in patients, is practically insufficient to oxidize biomolecules and induce CVDs. Despite vitamin C and E levels being well within normal limits, the TAA was significantly and considerably lower in patients. This is a highly interesting observation suggesting that dietary antioxidants other than these vitamins were preferentially consumed to control OS because procedure for TAA used in this study practically measures only total dietary antioxidants. CONCLUSION: OS does not appear to be an etiological factor for the cardiovascular diseases; rather slightly raised OS in patients seems to be a consequence. Further the raised OS was not due to lower nutrient antioxidant (vit. C and vit. E) in the local population studied herein. SN - 1812-2078 UR - https://www.unboundmedicine.com/medline/citation/18603918/Oxidative_stress_and_antioxidant_status_in_cardiovascular_diseases_in_population_of_western_Nepal_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -