Tags

Type your tag names separated by a space and hit enter

Effects of purified micronized flavonoid fraction (Detralex) on prophylactic treatment of adjuvant arthritis with methotrexate in rats.
Isr Med Assoc J. 2008 May; 10(5):377-80.IM

Abstract

BACKGROUND

In both adjuvant arthritis and rheumatoid arthritis, edema and inflammation appear in synovial joints. Edema or effusion reflects an imbalance in lymph dynamics. Purified micronized flavonoid fraction is mainly used in the treatment of chronic venous insufficiency. This compound improves lymphatic drainage with a signicant increase in lymphatic flow and lymphatic pulsality. It is suggested that the beneficial effect of purified micronized flavonoid fraction may be involved in the treatment of adjuvant arthritis in rats.

OBJECTIVES

To evaluate the effect of Detralex on methotrexate prophylactic treatment of adjuvant arthritis in rats.

METHODS

Groups of rats with adjuvant arthritis were treated with methotrexate (0.6 mg/kg/week), Detralex (20 mg/kg/day) and their combination for 50 days from adjuvant application. Hind paw swelling, arthrogram scores, serum albumin level, serum nitrite/nitrate concentrations and whole body mineral density were evaluated as markers of inflammation and destructive changes associated with arthritis.

RESULTS

Long-term prophylactic treatment with low dose methotrexate significantly inhibited the markers of both inflammation and arthritis. Detralex administered alone slightly decreased both the hind paw swelling and the arthritic score. Other inflammatory and arthritic markers were not significantly influenced. However, Detralex combined with methotrexate markedly potentiated the beneficial effects of methotrexate, which resulted in a more significant reduction in hind paw swelling, arthritic scores, and serum concentrations of nitrite/nitrate. Interestingly, the arthritis-induced decrease of BMD in AA rats was significantly lower only in the group treated with the combination of Detralex+methotrexate.

CONCLUSION

Detralex increased the therapeutic efficacy of methotrexate basal treatment in AA. We suggest that this may be related to the beneficial effect of Detralex on microcirculation, especially on venules and lymphatic vessels.

Authors+Show Affiliations

National Institute of Rheumatic Diseases, Piest'any, Slovak Republic. rovensky.jozef@nurch.skNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18605365

Citation

Rovenský, Jozef, et al. "Effects of Purified Micronized Flavonoid Fraction (Detralex) On Prophylactic Treatment of Adjuvant Arthritis With Methotrexate in Rats." The Israel Medical Association Journal : IMAJ, vol. 10, no. 5, 2008, pp. 377-80.
Rovenský J, Svík K, Rovenská E, et al. Effects of purified micronized flavonoid fraction (Detralex) on prophylactic treatment of adjuvant arthritis with methotrexate in rats. Isr Med Assoc J. 2008;10(5):377-80.
Rovenský, J., Svík, K., Rovenská, E., Stvrtinová, V., & Stancíková, M. (2008). Effects of purified micronized flavonoid fraction (Detralex) on prophylactic treatment of adjuvant arthritis with methotrexate in rats. The Israel Medical Association Journal : IMAJ, 10(5), 377-80.
Rovenský J, et al. Effects of Purified Micronized Flavonoid Fraction (Detralex) On Prophylactic Treatment of Adjuvant Arthritis With Methotrexate in Rats. Isr Med Assoc J. 2008;10(5):377-80. PubMed PMID: 18605365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of purified micronized flavonoid fraction (Detralex) on prophylactic treatment of adjuvant arthritis with methotrexate in rats. AU - Rovenský,Jozef, AU - Svík,Karol, AU - Rovenská,Emília, AU - Stvrtinová,Viera, AU - Stancíková,Mária, PY - 2008/7/9/pubmed PY - 2008/7/31/medline PY - 2008/7/9/entrez SP - 377 EP - 80 JF - The Israel Medical Association journal : IMAJ JO - Isr. Med. Assoc. J. VL - 10 IS - 5 N2 - BACKGROUND: In both adjuvant arthritis and rheumatoid arthritis, edema and inflammation appear in synovial joints. Edema or effusion reflects an imbalance in lymph dynamics. Purified micronized flavonoid fraction is mainly used in the treatment of chronic venous insufficiency. This compound improves lymphatic drainage with a signicant increase in lymphatic flow and lymphatic pulsality. It is suggested that the beneficial effect of purified micronized flavonoid fraction may be involved in the treatment of adjuvant arthritis in rats. OBJECTIVES: To evaluate the effect of Detralex on methotrexate prophylactic treatment of adjuvant arthritis in rats. METHODS: Groups of rats with adjuvant arthritis were treated with methotrexate (0.6 mg/kg/week), Detralex (20 mg/kg/day) and their combination for 50 days from adjuvant application. Hind paw swelling, arthrogram scores, serum albumin level, serum nitrite/nitrate concentrations and whole body mineral density were evaluated as markers of inflammation and destructive changes associated with arthritis. RESULTS: Long-term prophylactic treatment with low dose methotrexate significantly inhibited the markers of both inflammation and arthritis. Detralex administered alone slightly decreased both the hind paw swelling and the arthritic score. Other inflammatory and arthritic markers were not significantly influenced. However, Detralex combined with methotrexate markedly potentiated the beneficial effects of methotrexate, which resulted in a more significant reduction in hind paw swelling, arthritic scores, and serum concentrations of nitrite/nitrate. Interestingly, the arthritis-induced decrease of BMD in AA rats was significantly lower only in the group treated with the combination of Detralex+methotrexate. CONCLUSION: Detralex increased the therapeutic efficacy of methotrexate basal treatment in AA. We suggest that this may be related to the beneficial effect of Detralex on microcirculation, especially on venules and lymphatic vessels. SN - 1565-1088 UR - https://www.unboundmedicine.com/medline/citation/18605365/Effects_of_purified_micronized_flavonoid_fraction__Detralex__on_prophylactic_treatment_of_adjuvant_arthritis_with_methotrexate_in_rats_ L2 - http://www.ima.org.il/IMAJ/ViewArticle.aspx?year=2008&month=05&page=377 DB - PRIME DP - Unbound Medicine ER -