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Survival patterns among lymphoma patients with a family history of lymphoma.
J Clin Oncol 2008; 26(30):4958-65JC

Abstract

PURPOSE

Genetic factors are important in the etiology and pathogenesis of chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). Only a few small studies have assessed clinical characteristics and prognosis for familial patients, with inconsistent findings.

METHODS

Using population-based registries from Sweden and Denmark, 7,749 patients with CLL, 7,476 patients with HL, and 25,801 patients with NHL with linkable first-degree relatives were identified. Kaplan-Meier curves were constructed to compare survival in patients with lymphoma with and without a family history of lymphoma. The risk of dying was assessed using adjusted Cox proportional hazard models.

RESULTS

We found 85 patients with CLL (1.10%), 95 patients with HL (1.28%), and 206 patients with NHL (0.80%) with a family history of any lymphoma. Five-year mortality was similar for patients with CLL (hazard ratio [HR], 1.28; 95% CI, 0.95 to 1.72), HL (HR, 0.78; 95% CI, 0.49 to 1.25), and NHL (HR, 0.91; 95% CI, 0.74 to 1.12) versus without a family history of any lymphoma. Mortality was also similar for patients with versus without a family history of the same lymphoma. T-cell/anaplastic lymphoma patients with a family history of NHL had poorer outcome 5-years after diagnosis (HR, 5.38; 95% CI, 1.65 to 17.52). Results were similar for 10 years of follow-up.

CONCLUSION

With the exception of T-cell/anaplastic lymphoma, survival patterns for patients with CLL, HL, and NHL with a family history of lymphoma were similar to those for sporadic patients, suggesting that most familial lymphomas do not have an altered clinical course. Our findings provide no evidence to modify therapeutic strategies for patients with CLL, HL, or NHL based solely on family history.

Authors+Show Affiliations

Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA. l.anderson@qub.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18606984

Citation

Anderson, Lesley A., et al. "Survival Patterns Among Lymphoma Patients With a Family History of Lymphoma." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 26, no. 30, 2008, pp. 4958-65.
Anderson LA, Pfeiffer RM, Rapkin JS, et al. Survival patterns among lymphoma patients with a family history of lymphoma. J Clin Oncol. 2008;26(30):4958-65.
Anderson, L. A., Pfeiffer, R. M., Rapkin, J. S., Gridley, G., Mellemkjaer, L., Hemminki, K., ... Landgren, O. (2008). Survival patterns among lymphoma patients with a family history of lymphoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 26(30), pp. 4958-65. doi:10.1200/JCO.2007.14.6571.
Anderson LA, et al. Survival Patterns Among Lymphoma Patients With a Family History of Lymphoma. J Clin Oncol. 2008 Oct 20;26(30):4958-65. PubMed PMID: 18606984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Survival patterns among lymphoma patients with a family history of lymphoma. AU - Anderson,Lesley A, AU - Pfeiffer,Ruth M, AU - Rapkin,Joshua S, AU - Gridley,Gloria, AU - Mellemkjaer,Lene, AU - Hemminki,Kari, AU - Björkholm,Magnus, AU - Caporaso,Neil E, AU - Landgren,Ola, Y1 - 2008/07/07/ PY - 2008/7/9/pubmed PY - 2008/10/28/medline PY - 2008/7/9/entrez SP - 4958 EP - 65 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J. Clin. Oncol. VL - 26 IS - 30 N2 - PURPOSE: Genetic factors are important in the etiology and pathogenesis of chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). Only a few small studies have assessed clinical characteristics and prognosis for familial patients, with inconsistent findings. METHODS: Using population-based registries from Sweden and Denmark, 7,749 patients with CLL, 7,476 patients with HL, and 25,801 patients with NHL with linkable first-degree relatives were identified. Kaplan-Meier curves were constructed to compare survival in patients with lymphoma with and without a family history of lymphoma. The risk of dying was assessed using adjusted Cox proportional hazard models. RESULTS: We found 85 patients with CLL (1.10%), 95 patients with HL (1.28%), and 206 patients with NHL (0.80%) with a family history of any lymphoma. Five-year mortality was similar for patients with CLL (hazard ratio [HR], 1.28; 95% CI, 0.95 to 1.72), HL (HR, 0.78; 95% CI, 0.49 to 1.25), and NHL (HR, 0.91; 95% CI, 0.74 to 1.12) versus without a family history of any lymphoma. Mortality was also similar for patients with versus without a family history of the same lymphoma. T-cell/anaplastic lymphoma patients with a family history of NHL had poorer outcome 5-years after diagnosis (HR, 5.38; 95% CI, 1.65 to 17.52). Results were similar for 10 years of follow-up. CONCLUSION: With the exception of T-cell/anaplastic lymphoma, survival patterns for patients with CLL, HL, and NHL with a family history of lymphoma were similar to those for sporadic patients, suggesting that most familial lymphomas do not have an altered clinical course. Our findings provide no evidence to modify therapeutic strategies for patients with CLL, HL, or NHL based solely on family history. SN - 1527-7755 UR - https://www.unboundmedicine.com/medline/citation/18606984/Survival_patterns_among_lymphoma_patients_with_a_family_history_of_lymphoma_ L2 - http://ascopubs.org/doi/full/10.1200/JCO.2007.14.6571?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -