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Endocannabinoid system in food intake and metabolic regulation.
Curr Opin Lipidol 2008; 19(4):344-8CO

Abstract

PURPOSE OF REVIEW

As the incidence of obesity and the metabolic syndrome has increased, research has focused on the importance of the endocannabinoid system in the brain and peripheral tissues. Rimonabant, an inverse agonist of the CB1 receptor is being used therapeutically. This review presents recent advances in endocannabinoid physiology.

RECENT FINDINGS

The endocannabinoid system interacts with other anorexigenic and orexigenic pathways to regulate food intake in the hypothalamus, and the hedonistic value of food in the mesolimbic system. Endocannabinoid system overactivity contributes to hepatic steatosis, increased adipose tissue inflammation, dysregulated insulin signalling in the pancreas and disturbed oxidative pathways in skeletal muscle. The breakdown pathways for anandamide and 2-arachidonoylglycerol, the endocannabinoid receptor ligands, are reviewed, and the recent discoveries of endocannabinoid receptor polymorphisms and their relationship to obesity and metabolic disease noted. The favourable effect of rimonabant on fat mass glycaemic control, lipid metabolism and overall cardiovascular risk must be tempered by adverse effects on mood.

SUMMARY

The ubiquitous role of the endocannabinoid system in food intake and energy metabolism is now established. Drugs that manipulate different aspects of this system may benefit subjects with the metabolic and cachectic syndromes.

Authors+Show Affiliations

University of Adelaide, Adelaide, Australia.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18607180

Citation

Jesudason, David, and Gary Wittert. "Endocannabinoid System in Food Intake and Metabolic Regulation." Current Opinion in Lipidology, vol. 19, no. 4, 2008, pp. 344-8.
Jesudason D, Wittert G. Endocannabinoid system in food intake and metabolic regulation. Curr Opin Lipidol. 2008;19(4):344-8.
Jesudason, D., & Wittert, G. (2008). Endocannabinoid system in food intake and metabolic regulation. Current Opinion in Lipidology, 19(4), pp. 344-8. doi:10.1097/MOL.0b013e328304b62b.
Jesudason D, Wittert G. Endocannabinoid System in Food Intake and Metabolic Regulation. Curr Opin Lipidol. 2008;19(4):344-8. PubMed PMID: 18607180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocannabinoid system in food intake and metabolic regulation. AU - Jesudason,David, AU - Wittert,Gary, PY - 2008/7/9/pubmed PY - 2008/10/7/medline PY - 2008/7/9/entrez SP - 344 EP - 8 JF - Current opinion in lipidology JO - Curr. Opin. Lipidol. VL - 19 IS - 4 N2 - PURPOSE OF REVIEW: As the incidence of obesity and the metabolic syndrome has increased, research has focused on the importance of the endocannabinoid system in the brain and peripheral tissues. Rimonabant, an inverse agonist of the CB1 receptor is being used therapeutically. This review presents recent advances in endocannabinoid physiology. RECENT FINDINGS: The endocannabinoid system interacts with other anorexigenic and orexigenic pathways to regulate food intake in the hypothalamus, and the hedonistic value of food in the mesolimbic system. Endocannabinoid system overactivity contributes to hepatic steatosis, increased adipose tissue inflammation, dysregulated insulin signalling in the pancreas and disturbed oxidative pathways in skeletal muscle. The breakdown pathways for anandamide and 2-arachidonoylglycerol, the endocannabinoid receptor ligands, are reviewed, and the recent discoveries of endocannabinoid receptor polymorphisms and their relationship to obesity and metabolic disease noted. The favourable effect of rimonabant on fat mass glycaemic control, lipid metabolism and overall cardiovascular risk must be tempered by adverse effects on mood. SUMMARY: The ubiquitous role of the endocannabinoid system in food intake and energy metabolism is now established. Drugs that manipulate different aspects of this system may benefit subjects with the metabolic and cachectic syndromes. SN - 0957-9672 UR - https://www.unboundmedicine.com/medline/citation/18607180/Endocannabinoid_system_in_food_intake_and_metabolic_regulation_ L2 - http://Insights.ovid.com/pubmed?pmid=18607180 DB - PRIME DP - Unbound Medicine ER -