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The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity.
Curr Opin Lipidol. 2008 Aug; 19(4):369-77.CO

Abstract

PURPOSE OF REVIEW

To review emerging data on the relationship between lipoprotein(a) and oxidized phospholipids.

RECENT FINDINGS

We have recently proposed that a unique physiological role of lipoprotein(a) may be to bind and transport proinflammatory oxidized phospholipids and that this interaction may mediate a common biological influence on cardiovascular disease. In a large series of clinical studies performed to date, a very strong correlation was found between plasma levels of lipoprotein(a) and the content of oxidized phospholipids on apolipoprotein B-100 particles (OxPL/apoB), measured by monoclonal antibody E06, which binds the phosphocholine head group of oxidized phospholipids but not native phospholipids. The correlation of OxPL/apoB to lipoprotein(a) is very strong in individuals with small apolipoprotein(a) isoforms (r = approximately 0.95) and modest in individuals with large isoforms (r = approximately 0.60). In-vitro studies have demonstrated that the vast majority of oxidized phospholipids detected by E06 are bound to lipoprotein(a) in human plasma. A similarly strong association with oxidized phospholipids was also documented in transgenic mice overexpressing lipoprotein(a), even in mice not fed atherogenic diets or with overt atherosclerosis.

SUMMARY

A better understanding of the ability of human lipoprotein(a) to bind oxidized phospholipids may allow clinically important insights into the role of oxidized phospholipids and lipoprotein(a) in human atherogenesis and cardiovascular disease and may provide novel diagnostic tools and therapeutic interventions aimed at measuring and treating elevated levels of OxPL/apoB and lipoprotein(a).

Authors+Show Affiliations

Vascular Medicine Program, Department of Medicine, University of California San Diego, Cardiovascular Diseases, La Jolla, CA 92037-0975, USA. stsimikas@ucsd.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18607184

Citation

Tsimikas, Sotirios, and Joseph L. Witztum. "The Role of Oxidized Phospholipids in Mediating Lipoprotein(a) Atherogenicity." Current Opinion in Lipidology, vol. 19, no. 4, 2008, pp. 369-77.
Tsimikas S, Witztum JL. The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity. Curr Opin Lipidol. 2008;19(4):369-77.
Tsimikas, S., & Witztum, J. L. (2008). The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity. Current Opinion in Lipidology, 19(4), 369-77. https://doi.org/10.1097/MOL.0b013e328308b622
Tsimikas S, Witztum JL. The Role of Oxidized Phospholipids in Mediating Lipoprotein(a) Atherogenicity. Curr Opin Lipidol. 2008;19(4):369-77. PubMed PMID: 18607184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity. AU - Tsimikas,Sotirios, AU - Witztum,Joseph L, PY - 2008/7/9/pubmed PY - 2008/10/7/medline PY - 2008/7/9/entrez SP - 369 EP - 77 JF - Current opinion in lipidology JO - Curr. Opin. Lipidol. VL - 19 IS - 4 N2 - PURPOSE OF REVIEW: To review emerging data on the relationship between lipoprotein(a) and oxidized phospholipids. RECENT FINDINGS: We have recently proposed that a unique physiological role of lipoprotein(a) may be to bind and transport proinflammatory oxidized phospholipids and that this interaction may mediate a common biological influence on cardiovascular disease. In a large series of clinical studies performed to date, a very strong correlation was found between plasma levels of lipoprotein(a) and the content of oxidized phospholipids on apolipoprotein B-100 particles (OxPL/apoB), measured by monoclonal antibody E06, which binds the phosphocholine head group of oxidized phospholipids but not native phospholipids. The correlation of OxPL/apoB to lipoprotein(a) is very strong in individuals with small apolipoprotein(a) isoforms (r = approximately 0.95) and modest in individuals with large isoforms (r = approximately 0.60). In-vitro studies have demonstrated that the vast majority of oxidized phospholipids detected by E06 are bound to lipoprotein(a) in human plasma. A similarly strong association with oxidized phospholipids was also documented in transgenic mice overexpressing lipoprotein(a), even in mice not fed atherogenic diets or with overt atherosclerosis. SUMMARY: A better understanding of the ability of human lipoprotein(a) to bind oxidized phospholipids may allow clinically important insights into the role of oxidized phospholipids and lipoprotein(a) in human atherogenesis and cardiovascular disease and may provide novel diagnostic tools and therapeutic interventions aimed at measuring and treating elevated levels of OxPL/apoB and lipoprotein(a). SN - 0957-9672 UR - https://www.unboundmedicine.com/medline/citation/18607184/The_role_of_oxidized_phospholipids_in_mediating_lipoprotein_a__atherogenicity_ L2 - http://dx.doi.org/10.1097/MOL.0b013e328308b622 DB - PRIME DP - Unbound Medicine ER -