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Spontaneous and induced abortions and risk of breast cancer.
Int J Cancer 1991; 48(6):816-20IJ

Abstract

The relationship between spontaneous or induced abortion and the risk of breast cancer was analyzed in a case-control study conducted in the greater Milan area on 2,394 cases of breast cancer and 2,218 controls in hospital for a spectrum of acute conditions, not gynecological, hormonal or neoplastic. No consistent relationship emerged between spontaneous or induced abortion and breast cancer: compared with women reporting no abortions (spontaneous or induced), the multivariate relative risk (RR) was 1.0 (95% confidence interval, CI, 0.9 to 1.2) in those reporting one abortion and 0.9 (95% CI 0.7 to 1.0) in those reporting two or more. This lack of association was consistent in strata of age and parity, including younger women. We further analyzed the risk of breast cancer associated with an abortion before and after full-term pregnancy. Compared with parous women reporting no induced or spontaneous abortions, those who had an abortion before their first full-term pregnancy had about a 20% higher risk of breast cancer. This finding, however, was not statistically significant (RR 1.2, 95% CI 0.9 to 1.7). No increased risk was observed in women who had had a first abortion after a full-term pregnancy (RR 0.9, 95% CI 0.8 to 1.0). This study does not support the hypothesis that spontaneous or induced abortion appreciably influences subsequent breast-cancer risk.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1860729

Citation

Parazzini, F, et al. "Spontaneous and Induced Abortions and Risk of Breast Cancer." International Journal of Cancer, vol. 48, no. 6, 1991, pp. 816-20.
Parazzini F, La Vecchia C, Negri E. Spontaneous and induced abortions and risk of breast cancer. Int J Cancer. 1991;48(6):816-20.
Parazzini, F., La Vecchia, C., & Negri, E. (1991). Spontaneous and induced abortions and risk of breast cancer. International Journal of Cancer, 48(6), pp. 816-20.
Parazzini F, La Vecchia C, Negri E. Spontaneous and Induced Abortions and Risk of Breast Cancer. Int J Cancer. 1991 Jul 30;48(6):816-20. PubMed PMID: 1860729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spontaneous and induced abortions and risk of breast cancer. AU - Parazzini,F, AU - La Vecchia,C, AU - Negri,E, PY - 1991/7/30/pubmed PY - 1991/7/30/medline PY - 1991/7/30/entrez KW - Abortion, Induced KW - Abortion, Spontaneous KW - Age Factors KW - Biology KW - Breast Cancer KW - Cancer KW - Case Control Studies KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Fertility KW - Fertility Control, Postconception KW - Fertility Measurements KW - Italy KW - Mediterranean Countries KW - Neoplasms KW - Parity KW - Population KW - Population Characteristics KW - Population Dynamics KW - Pregnancy Complications KW - Research Methodology KW - Risk Factors KW - Southern Europe KW - Studies SP - 816 EP - 20 JF - International journal of cancer JO - Int. J. Cancer VL - 48 IS - 6 N2 - The relationship between spontaneous or induced abortion and the risk of breast cancer was analyzed in a case-control study conducted in the greater Milan area on 2,394 cases of breast cancer and 2,218 controls in hospital for a spectrum of acute conditions, not gynecological, hormonal or neoplastic. No consistent relationship emerged between spontaneous or induced abortion and breast cancer: compared with women reporting no abortions (spontaneous or induced), the multivariate relative risk (RR) was 1.0 (95% confidence interval, CI, 0.9 to 1.2) in those reporting one abortion and 0.9 (95% CI 0.7 to 1.0) in those reporting two or more. This lack of association was consistent in strata of age and parity, including younger women. We further analyzed the risk of breast cancer associated with an abortion before and after full-term pregnancy. Compared with parous women reporting no induced or spontaneous abortions, those who had an abortion before their first full-term pregnancy had about a 20% higher risk of breast cancer. This finding, however, was not statistically significant (RR 1.2, 95% CI 0.9 to 1.7). No increased risk was observed in women who had had a first abortion after a full-term pregnancy (RR 0.9, 95% CI 0.8 to 1.0). This study does not support the hypothesis that spontaneous or induced abortion appreciably influences subsequent breast-cancer risk. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/1860729/Spontaneous_and_induced_abortions_and_risk_of_breast_cancer_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0020-7136&date=1991&volume=48&issue=6&spage=816 DB - PRIME DP - Unbound Medicine ER -