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Detection of respiratory viruses in nasopharyngeal secretions and middle ear fluid from children with acute otitis media.
Acta Otolaryngol. 2009 Jan; 129(1):19-24.AO

Abstract

CONCLUSIONS

Our results suggest that various respiratory viruses contribute to the pathogenesis of acute otitis media (AOM).

OBJECTIVE

AOM is one of the most common complications of viral upper respiratory tract infections in children. Recently, the importance of respiratory viruses has been stressed as causative agents of AOM.

SUBJECTS AND METHODS

A total of 1092 children < or =10 years old (average age 1.38 years) diagnosed as having AOM between 2002 and 2004 were studied. Bacterial and viral cultures of both nasopharyngeal secretions (NPS) and middle ear fluid (MEF) were performed for all 1092 children. Body temperature, changes of the tympanic membrane, and the number of days from the onset of illness were analyzed.

RESULTS

Respiratory viruses were detected in 360 of 1092 NPS specimens, including 157 isolates of respiratory syncytial virus and 88 of influenza virus. Among 1092 MEF specimens, 102 were virus-positive, including 43 for respiratory syncytial virus and 29 for influenza virus. In 75 children, respiratory viruses were only detected in MEF. The viral detection rate was higher in children with fever at an early stage of their illness. The tympanic membrane changes associated with viral infection tended to be less severe, while changes were more severe in cases with bacterial infection, especially co-infection with bacteria and viruses.

Authors+Show Affiliations

Virus Research Center, Clinical Research Division, Sendai Medical Center, Miyagino-ku, Sendai, Japan. yanohisa@orl.med.tohoku.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18607974

Citation

Yano, Hisakazu, et al. "Detection of Respiratory Viruses in Nasopharyngeal Secretions and Middle Ear Fluid From Children With Acute Otitis Media." Acta Oto-laryngologica, vol. 129, no. 1, 2009, pp. 19-24.
Yano H, Okitsu N, Hori T, et al. Detection of respiratory viruses in nasopharyngeal secretions and middle ear fluid from children with acute otitis media. Acta Otolaryngol. 2009;129(1):19-24.
Yano, H., Okitsu, N., Hori, T., Watanabe, O., Kisu, T., Hatagishi, E., Suzuki, A., Okamoto, M., Ohmi, A., Suetake, M., Sagai, S., Kobayashi, T., & Nishimura, H. (2009). Detection of respiratory viruses in nasopharyngeal secretions and middle ear fluid from children with acute otitis media. Acta Oto-laryngologica, 129(1), 19-24. https://doi.org/10.1080/00016480802032777
Yano H, et al. Detection of Respiratory Viruses in Nasopharyngeal Secretions and Middle Ear Fluid From Children With Acute Otitis Media. Acta Otolaryngol. 2009;129(1):19-24. PubMed PMID: 18607974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of respiratory viruses in nasopharyngeal secretions and middle ear fluid from children with acute otitis media. AU - Yano,Hisakazu, AU - Okitsu,Naohiro, AU - Hori,Toru, AU - Watanabe,Oshi, AU - Kisu,Tomoko, AU - Hatagishi,Etsuko, AU - Suzuki,Akira, AU - Okamoto,Michiko, AU - Ohmi,Akira, AU - Suetake,Mitsuko, AU - Sagai,Syun, AU - Kobayashi,Toshimitsu, AU - Nishimura,Hidekazu, PY - 2008/7/9/pubmed PY - 2009/3/12/medline PY - 2008/7/9/entrez SP - 19 EP - 24 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 129 IS - 1 N2 - CONCLUSIONS: Our results suggest that various respiratory viruses contribute to the pathogenesis of acute otitis media (AOM). OBJECTIVE: AOM is one of the most common complications of viral upper respiratory tract infections in children. Recently, the importance of respiratory viruses has been stressed as causative agents of AOM. SUBJECTS AND METHODS: A total of 1092 children < or =10 years old (average age 1.38 years) diagnosed as having AOM between 2002 and 2004 were studied. Bacterial and viral cultures of both nasopharyngeal secretions (NPS) and middle ear fluid (MEF) were performed for all 1092 children. Body temperature, changes of the tympanic membrane, and the number of days from the onset of illness were analyzed. RESULTS: Respiratory viruses were detected in 360 of 1092 NPS specimens, including 157 isolates of respiratory syncytial virus and 88 of influenza virus. Among 1092 MEF specimens, 102 were virus-positive, including 43 for respiratory syncytial virus and 29 for influenza virus. In 75 children, respiratory viruses were only detected in MEF. The viral detection rate was higher in children with fever at an early stage of their illness. The tympanic membrane changes associated with viral infection tended to be less severe, while changes were more severe in cases with bacterial infection, especially co-infection with bacteria and viruses. SN - 1651-2251 UR - https://www.unboundmedicine.com/medline/citation/18607974/Detection_of_respiratory_viruses_in_nasopharyngeal_secretions_and_middle_ear_fluid_from_children_with_acute_otitis_media_ DB - PRIME DP - Unbound Medicine ER -