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Effects of Japanese herbal medicine, Juzen-taiho-to, in otitis-prone children--a preliminary study.
Acta Otolaryngol 2009; 129(1):14-8AO

Abstract

CONCLUSION

Juzen-taiho-to (JTT, TJ-48), a Japanese herbal medicine that improves immune function, was found to be effective in otitis-prone in children.

OBJECTIVE

To evaluate the efficacy of JTT against intractable and recurrent infections in immature immune systems, we administered JTT to otitis-prone infants and investigated clinical changes before and during JTT administration.

SUBJECTS AND METHODS

Twenty-four otitis-prone infants were administered JTT at 0.10-0.14 g/kg/day twice a day for 3 months. We compared clinical course, such as frequency of acute otitis media (AOM), duration of fever and antibiotics administration, and hospital visits for the periods before and during JTT administration.

RESULTS

Medication compliance rate was 87.5%, and administration of JTT led to remission in 95.2% patients. No apparent side effects were observed. The frequency of AOM decreased significantly (Wilcoxon signed rank test, p=0.000) with JTT. The duration of fever (p=0.000) and administration of antibiotics (p=0.001), as well as the number of hospital visits (p=0.001) and emergent hospital visits (p=0.000) showed significant decreases after JTT administration. After the end of the JTT period, 14 of 21 (66.7%) patients started to take it again, as they experienced purulent otitis media and/or other infections after discontinuation. The frequency of AOM increased significantly after stopping JTT (p=0.004) and decreased again with JTT resumption (p=0.005).

Authors+Show Affiliations

Department of Otorhinolaryngology, Kurobe City Hospital, 1108-1 Mikkaichi, Kurobe, Toyama, Japan. maruyama@med.kurobe.toyama.jp

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18608005

Citation

Maruyama, Yumiko, et al. "Effects of Japanese Herbal Medicine, Juzen-taiho-to, in Otitis-prone Children--a Preliminary Study." Acta Oto-laryngologica, vol. 129, no. 1, 2009, pp. 14-8.
Maruyama Y, Hoshida S, Furukawa M, et al. Effects of Japanese herbal medicine, Juzen-taiho-to, in otitis-prone children--a preliminary study. Acta Otolaryngol. 2009;129(1):14-8.
Maruyama, Y., Hoshida, S., Furukawa, M., & Ito, M. (2009). Effects of Japanese herbal medicine, Juzen-taiho-to, in otitis-prone children--a preliminary study. Acta Oto-laryngologica, 129(1), pp. 14-8. doi:10.1080/00016480801998838.
Maruyama Y, et al. Effects of Japanese Herbal Medicine, Juzen-taiho-to, in Otitis-prone Children--a Preliminary Study. Acta Otolaryngol. 2009;129(1):14-8. PubMed PMID: 18608005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Japanese herbal medicine, Juzen-taiho-to, in otitis-prone children--a preliminary study. AU - Maruyama,Yumiko, AU - Hoshida,Shigeru, AU - Furukawa,Mitsuru, AU - Ito,Makoto, PY - 2008/7/9/pubmed PY - 2009/3/12/medline PY - 2008/7/9/entrez SP - 14 EP - 8 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 129 IS - 1 N2 - CONCLUSION: Juzen-taiho-to (JTT, TJ-48), a Japanese herbal medicine that improves immune function, was found to be effective in otitis-prone in children. OBJECTIVE: To evaluate the efficacy of JTT against intractable and recurrent infections in immature immune systems, we administered JTT to otitis-prone infants and investigated clinical changes before and during JTT administration. SUBJECTS AND METHODS: Twenty-four otitis-prone infants were administered JTT at 0.10-0.14 g/kg/day twice a day for 3 months. We compared clinical course, such as frequency of acute otitis media (AOM), duration of fever and antibiotics administration, and hospital visits for the periods before and during JTT administration. RESULTS: Medication compliance rate was 87.5%, and administration of JTT led to remission in 95.2% patients. No apparent side effects were observed. The frequency of AOM decreased significantly (Wilcoxon signed rank test, p=0.000) with JTT. The duration of fever (p=0.000) and administration of antibiotics (p=0.001), as well as the number of hospital visits (p=0.001) and emergent hospital visits (p=0.000) showed significant decreases after JTT administration. After the end of the JTT period, 14 of 21 (66.7%) patients started to take it again, as they experienced purulent otitis media and/or other infections after discontinuation. The frequency of AOM increased significantly after stopping JTT (p=0.004) and decreased again with JTT resumption (p=0.005). SN - 1651-2251 UR - https://www.unboundmedicine.com/medline/citation/18608005/Effects_of_Japanese_herbal_medicine_Juzen_taiho_to_in_otitis_prone_children__a_preliminary_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/00016480801998838 DB - PRIME DP - Unbound Medicine ER -