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Autonomic dysfunction in cirrhosis and portal hypertension.
Scand J Clin Lab Invest. 2008; 68(6):437-47.SJ

Abstract

Liver cirrhosis and portal hypertension are frequently associated with signs of circulatory dysfunction and peripheral polyneuropathy, which includes defects of the autonomic nervous system. Autonomic dysfunction, which is seen in both alcoholic and non-alcoholic liver cirrhosis and increases with severity and duration of the liver disease, is associated with a significant increase in mortality. The lack of total resolution after liver transplantation indicates that the autonomic neuropathy is not exclusively functional. This article highlights some aspects of the autonomic dysfunction in chronic liver disease. A description is given of its aetiology and the typical circulatory dysfunction with characteristic hyperdynamic and hyporeactive circulation and heart failure, and the most important tests of the autonomic nervous system.

Authors+Show Affiliations

Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18609092

Citation

Dümcke, Christine Winkler, and Søren Møller. "Autonomic Dysfunction in Cirrhosis and Portal Hypertension." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 68, no. 6, 2008, pp. 437-47.
Dümcke CW, Møller S. Autonomic dysfunction in cirrhosis and portal hypertension. Scand J Clin Lab Invest. 2008;68(6):437-47.
Dümcke, C. W., & Møller, S. (2008). Autonomic dysfunction in cirrhosis and portal hypertension. Scandinavian Journal of Clinical and Laboratory Investigation, 68(6), 437-47. https://doi.org/10.1080/00365510701813096
Dümcke CW, Møller S. Autonomic Dysfunction in Cirrhosis and Portal Hypertension. Scand J Clin Lab Invest. 2008;68(6):437-47. PubMed PMID: 18609092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic dysfunction in cirrhosis and portal hypertension. AU - Dümcke,Christine Winkler, AU - Møller,Søren, PY - 2008/7/9/pubmed PY - 2009/2/5/medline PY - 2008/7/9/entrez SP - 437 EP - 47 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 68 IS - 6 N2 - Liver cirrhosis and portal hypertension are frequently associated with signs of circulatory dysfunction and peripheral polyneuropathy, which includes defects of the autonomic nervous system. Autonomic dysfunction, which is seen in both alcoholic and non-alcoholic liver cirrhosis and increases with severity and duration of the liver disease, is associated with a significant increase in mortality. The lack of total resolution after liver transplantation indicates that the autonomic neuropathy is not exclusively functional. This article highlights some aspects of the autonomic dysfunction in chronic liver disease. A description is given of its aetiology and the typical circulatory dysfunction with characteristic hyperdynamic and hyporeactive circulation and heart failure, and the most important tests of the autonomic nervous system. SN - 1502-7686 UR - https://www.unboundmedicine.com/medline/citation/18609092/Autonomic_dysfunction_in_cirrhosis_and_portal_hypertension_ L2 - https://www.tandfonline.com/doi/full/10.1080/00365510701813096 DB - PRIME DP - Unbound Medicine ER -