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Helicobacter pylori infection in children with celiac disease.
Scand J Gastroenterol. 2008; 43(9):1088-93.SJ

Abstract

OBJECTIVE

To analyze the prevalence of Helicobacter pylori (H. pylori) infection in children with celiac disease (CD) and to examine the role of H. pylori infection in clinical, laboratory and histopathological presentations of CD.

MATERIAL AND METHODS

Data on 96 children with CD and 235 children who underwent endoscopy were compared for the prevalence and gastric histology pattern of H. pylori. Clinical presentation, laboratory and histological findings of CD children with and without H. pylori infection were compared.

RESULTS

Twenty-one subjects (21.8%) in the CD group and 56 subjects (23.8%) in the control group had H. pylori gastritis. Gastric metaplasia is higher in CD patients with H. pylori gastritis (19%) than in patients without H. pylori gastritis (1.3%) and in the control group (3.5%) (p<0.05 for all groups). Abdominal distension is more common at initial admission in CD patients with H. pylori gastritis (57.1% versus 14.6%, p<0.05). No significant difference was found between H. pylori (+) and (-) CD patients in terms of prevalence of anemia, iron deficiency and iron-deficiency anemia. Only mild duodenal histological findings were more common in H. pylori patients (57.1% versus 26.7%, p<0.05).

CONCLUSIONS

CD may be associated with H. pylori gastritis, but it does not affect the clinical presentation of the disease, except for abdominal distension; CD is associated with mild duodenal lesions. A gluten-free diet improves the symptoms in all patients independently of the presence of H. pylori gastritis. Gastric metaplasia increases in the presence of H. pylori gastritis. Further prospective studies are needed to examine the clinical and histopathological outcomes of gastric metaplasia associated with H. pylori gastritis in CD patients.

Authors+Show Affiliations

Department of Pediatric Gastroenterology Hepatology and Nutrition, Ege University, Izmir, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18609161

Citation

Aydogdu, Sema, et al. "Helicobacter Pylori Infection in Children With Celiac Disease." Scandinavian Journal of Gastroenterology, vol. 43, no. 9, 2008, pp. 1088-93.
Aydogdu S, Cakir M, Yuksekkaya HA, et al. Helicobacter pylori infection in children with celiac disease. Scand J Gastroenterol. 2008;43(9):1088-93.
Aydogdu, S., Cakir, M., Yuksekkaya, H. A., Tumgor, G., Baran, M., Arikan, C., & Yagci, R. V. (2008). Helicobacter pylori infection in children with celiac disease. Scandinavian Journal of Gastroenterology, 43(9), 1088-93. https://doi.org/10.1080/00365520802101846
Aydogdu S, et al. Helicobacter Pylori Infection in Children With Celiac Disease. Scand J Gastroenterol. 2008;43(9):1088-93. PubMed PMID: 18609161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection in children with celiac disease. AU - Aydogdu,Sema, AU - Cakir,Murat, AU - Yuksekkaya,Hasan Ali, AU - Tumgor,Gokhan, AU - Baran,Masallah, AU - Arikan,Cigdem, AU - Yagci,Rasit V, PY - 2008/7/9/pubmed PY - 2008/10/22/medline PY - 2008/7/9/entrez SP - 1088 EP - 93 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 43 IS - 9 N2 - OBJECTIVE: To analyze the prevalence of Helicobacter pylori (H. pylori) infection in children with celiac disease (CD) and to examine the role of H. pylori infection in clinical, laboratory and histopathological presentations of CD. MATERIAL AND METHODS: Data on 96 children with CD and 235 children who underwent endoscopy were compared for the prevalence and gastric histology pattern of H. pylori. Clinical presentation, laboratory and histological findings of CD children with and without H. pylori infection were compared. RESULTS: Twenty-one subjects (21.8%) in the CD group and 56 subjects (23.8%) in the control group had H. pylori gastritis. Gastric metaplasia is higher in CD patients with H. pylori gastritis (19%) than in patients without H. pylori gastritis (1.3%) and in the control group (3.5%) (p<0.05 for all groups). Abdominal distension is more common at initial admission in CD patients with H. pylori gastritis (57.1% versus 14.6%, p<0.05). No significant difference was found between H. pylori (+) and (-) CD patients in terms of prevalence of anemia, iron deficiency and iron-deficiency anemia. Only mild duodenal histological findings were more common in H. pylori patients (57.1% versus 26.7%, p<0.05). CONCLUSIONS: CD may be associated with H. pylori gastritis, but it does not affect the clinical presentation of the disease, except for abdominal distension; CD is associated with mild duodenal lesions. A gluten-free diet improves the symptoms in all patients independently of the presence of H. pylori gastritis. Gastric metaplasia increases in the presence of H. pylori gastritis. Further prospective studies are needed to examine the clinical and histopathological outcomes of gastric metaplasia associated with H. pylori gastritis in CD patients. SN - 1502-7708 UR - https://www.unboundmedicine.com/medline/citation/18609161/Helicobacter_pylori_infection_in_children_with_celiac_disease_ L2 - https://www.tandfonline.com/doi/full/10.1080/00365520802101846 DB - PRIME DP - Unbound Medicine ER -