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Determination of local anaesthetics in body fluids by gas chromatography with surface ionization detection.
J Chromatogr. 1991 Mar 08; 564(1):278-82.JC

Abstract

Ten local anaesthetics were tested for their detection by gas chromatography (GC)-surface ionization detection (SID). Lidocaine, mepivacaine and bupivacaine were detected with the highest sensitivity; their detection limit was 5-10 pg in an injected volume. The sensitivity of other drugs, such as procaine, dibucaine tetracaine and oxybuprocaine, was an order of magnitude lower than that of the above three local anaesthetics. A detailed procedure for isolation of local anaesthetics from human whole blood and cerebrospinal fluid (CSF) by the use of Sep-Pak C18 cartridges, before the GC-SID, is also presented. The recovery of lidocaine, mepivacaine and bupivacaine, which had been added to 1 ml of whole blood or CSF, was close to 100%.

Authors+Show Affiliations

Department of Legal Medicine, Aichi Medical University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1860922

Citation

Hattori, H, et al. "Determination of Local Anaesthetics in Body Fluids By Gas Chromatography With Surface Ionization Detection." Journal of Chromatography, vol. 564, no. 1, 1991, pp. 278-82.
Hattori H, Yamamoto S, Yamada T, et al. Determination of local anaesthetics in body fluids by gas chromatography with surface ionization detection. J Chromatogr. 1991;564(1):278-82.
Hattori, H., Yamamoto, S., Yamada, T., & Suzuki, O. (1991). Determination of local anaesthetics in body fluids by gas chromatography with surface ionization detection. Journal of Chromatography, 564(1), 278-82.
Hattori H, et al. Determination of Local Anaesthetics in Body Fluids By Gas Chromatography With Surface Ionization Detection. J Chromatogr. 1991 Mar 8;564(1):278-82. PubMed PMID: 1860922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of local anaesthetics in body fluids by gas chromatography with surface ionization detection. AU - Hattori,H, AU - Yamamoto,S, AU - Yamada,T, AU - Suzuki,O, PY - 1991/3/8/pubmed PY - 1991/3/8/medline PY - 1991/3/8/entrez SP - 278 EP - 82 JF - Journal of chromatography JO - J Chromatogr VL - 564 IS - 1 N2 - Ten local anaesthetics were tested for their detection by gas chromatography (GC)-surface ionization detection (SID). Lidocaine, mepivacaine and bupivacaine were detected with the highest sensitivity; their detection limit was 5-10 pg in an injected volume. The sensitivity of other drugs, such as procaine, dibucaine tetracaine and oxybuprocaine, was an order of magnitude lower than that of the above three local anaesthetics. A detailed procedure for isolation of local anaesthetics from human whole blood and cerebrospinal fluid (CSF) by the use of Sep-Pak C18 cartridges, before the GC-SID, is also presented. The recovery of lidocaine, mepivacaine and bupivacaine, which had been added to 1 ml of whole blood or CSF, was close to 100%. UR - https://www.unboundmedicine.com/medline/citation/1860922/Determination_of_local_anaesthetics_in_body_fluids_by_gas_chromatography_with_surface_ionization_detection_ DB - PRIME DP - Unbound Medicine ER -