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[Genetic polymorphism in GST, NAT2, and MTRR and susceptibility to childhood acute leukemia].
Mol Biol (Mosk). 2008 Mar-Apr; 42(2):214-25.MB

Abstract

It is known that presence of xenobiotic-metabolizing gene polymorphisms in some cases correlates with hereditary predisposition to the oncological diseases. In the present work the frequencies of xenobiotic-metabolizing gene polymorphisms in 332 children with the diagnosis acute lymphoblastic leukemia (ALL), 71 children with the diagnosis acute myeloblastic leukemia (AML) and 490 healthy donors have been determined using allele-specific hybridization on the biochip. Statistically significant increase in the frequency of GSTT1 "null" genotype (OR = 1.9, p = 4.7E-5) and GSTT1/GSTM1 double "null" genotype (OR = 3.1, p = 2.5E-8) in children with acute leukemia relative to healthy donors group has been revealed. Also 1.8-fold increase in the frequency of NAT2 genotype 341T/T, 481C/C, 590G/G in children with acute leukemia relative to healthy donors group (p = 0.026) has been recognized. Analysis of gene-gene interactions has showed that in patients with acute leukemia genotype NAT2 341T/T, 481C/C, 590G/G in combination with GSTT1 "null" and/or GSTM1 "null" genotype is significantly more frequent than in population control. Besides the reduction of MTRR genotype 66G/G frequency in girls with acute leukemia relative to female healthy donors has been found (OR = 0.50, p = 0.0015). Analysis of gene-gene interactions has shown that the presence of GSTT1 "null" and/or GSTM1 "null" genotype in combination with MTRR genotype 66A/- may consider as risk factor of acute leukemia in girls. Thus, the studied polymorphic variants of genes GSTT1, GSTM1, NAT2 and MTRR can modulate the risk of childhood acute leukemia, residents of European part of Russia.

Authors

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Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

rus

PubMed ID

18610829

Citation

Gra, O A., et al. "[Genetic Polymorphism in GST, NAT2, and MTRR and Susceptibility to Childhood Acute Leukemia]." Molekuliarnaia Biologiia, vol. 42, no. 2, 2008, pp. 214-25.
Gra OA, Glotov AS, Kozhekbaeva Zhm, et al. [Genetic polymorphism in GST, NAT2, and MTRR and susceptibility to childhood acute leukemia]. Mol Biol (Mosk). 2008;42(2):214-25.
Gra, O. A., Glotov, A. S., Kozhekbaeva, Z. h. m., Makarova, O. V., & Nasedkina, T. V. (2008). [Genetic polymorphism in GST, NAT2, and MTRR and susceptibility to childhood acute leukemia]. Molekuliarnaia Biologiia, 42(2), 214-25.
Gra OA, et al. [Genetic Polymorphism in GST, NAT2, and MTRR and Susceptibility to Childhood Acute Leukemia]. Mol Biol (Mosk). 2008 Mar-Apr;42(2):214-25. PubMed PMID: 18610829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Genetic polymorphism in GST, NAT2, and MTRR and susceptibility to childhood acute leukemia]. AU - Gra,O A, AU - Glotov,A S, AU - Kozhekbaeva,Zh m, AU - Makarova,O V, AU - Nasedkina,T V, PY - 2008/7/10/pubmed PY - 2008/7/30/medline PY - 2008/7/10/entrez SP - 214 EP - 25 JF - Molekuliarnaia biologiia JO - Mol Biol (Mosk) VL - 42 IS - 2 N2 - It is known that presence of xenobiotic-metabolizing gene polymorphisms in some cases correlates with hereditary predisposition to the oncological diseases. In the present work the frequencies of xenobiotic-metabolizing gene polymorphisms in 332 children with the diagnosis acute lymphoblastic leukemia (ALL), 71 children with the diagnosis acute myeloblastic leukemia (AML) and 490 healthy donors have been determined using allele-specific hybridization on the biochip. Statistically significant increase in the frequency of GSTT1 "null" genotype (OR = 1.9, p = 4.7E-5) and GSTT1/GSTM1 double "null" genotype (OR = 3.1, p = 2.5E-8) in children with acute leukemia relative to healthy donors group has been revealed. Also 1.8-fold increase in the frequency of NAT2 genotype 341T/T, 481C/C, 590G/G in children with acute leukemia relative to healthy donors group (p = 0.026) has been recognized. Analysis of gene-gene interactions has showed that in patients with acute leukemia genotype NAT2 341T/T, 481C/C, 590G/G in combination with GSTT1 "null" and/or GSTM1 "null" genotype is significantly more frequent than in population control. Besides the reduction of MTRR genotype 66G/G frequency in girls with acute leukemia relative to female healthy donors has been found (OR = 0.50, p = 0.0015). Analysis of gene-gene interactions has shown that the presence of GSTT1 "null" and/or GSTM1 "null" genotype in combination with MTRR genotype 66A/- may consider as risk factor of acute leukemia in girls. Thus, the studied polymorphic variants of genes GSTT1, GSTM1, NAT2 and MTRR can modulate the risk of childhood acute leukemia, residents of European part of Russia. SN - 0026-8984 UR - https://www.unboundmedicine.com/medline/citation/18610829/[Genetic_polymorphism_in_GST_NAT2_and_MTRR_and_susceptibility_to_childhood_acute_leukemia]_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=18610829.ui DB - PRIME DP - Unbound Medicine ER -