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Diphenyl diselenide reverses gastric lesions in rats: Involvement of oxidative stress.
Food Chem Toxicol. 2008 Sep; 46(9):3023-9.FC

Abstract

The aim of the present study was to evaluate if diphenyl diselenide administered by oral route was effective in restoring gastric lesions induced by ethanol. The possible involvement of oxidative stress in diphenyl diselenide antiulcer effect was also evaluated. Different doses of diphenyl diselenide (dissolved in soya bean oil, 1mL/kg) were administered orally 1h before (pre-treatment study) or 1h after ethanol (70%, v/v, 2mL/kg, post-treatment study). Ulcer lesions were quantified 1h after ethanol administration (pre-treatment protocol) or 1h after diphenyl diselenide study (post-treatment protocol). Diphenyl diselenide (0.1-10mg/kg or 0.32-32micromol/kg), when administered previously or posteriorly prevented and reversed respectively, the development of gastric lesions induced by ethanol in rats. A number of markers of oxidative stress were examined in rat stomach including thiobarbituric acid reactive species (TBARS), catalase (CAT), superoxide dismutase (SOD), non-protein thiol groups (NPSH) and ascorbic acid. In addition to attenuating the gastric lesions, low doses of diphenyl diselenide prevented (pre-treatment) or reversed (post-treatment) the ethanol-induced changes in TBARS, SOD activity and ascorbic acid content. In conclusion, the present data reveal that diphenyl diselenide, administered by oral route, possesses an antiulcer effect by modulating antioxidant mechanisms.

Authors+Show Affiliations

Departamento de Química, Centro de Ciências Naturais e Exatas, Programa de Pos-Graduacao em Bioquimica Toxicologica, Universidade Federal de Santa Maria 97105-900, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18611424

Citation

Ineu, R P., et al. "Diphenyl Diselenide Reverses Gastric Lesions in Rats: Involvement of Oxidative Stress." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 9, 2008, pp. 3023-9.
Ineu RP, Pereira ME, Aschner M, et al. Diphenyl diselenide reverses gastric lesions in rats: Involvement of oxidative stress. Food Chem Toxicol. 2008;46(9):3023-9.
Ineu, R. P., Pereira, M. E., Aschner, M., Nogueira, C. W., Zeni, G., & Rocha, J. B. (2008). Diphenyl diselenide reverses gastric lesions in rats: Involvement of oxidative stress. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(9), 3023-9. https://doi.org/10.1016/j.fct.2008.06.007
Ineu RP, et al. Diphenyl Diselenide Reverses Gastric Lesions in Rats: Involvement of Oxidative Stress. Food Chem Toxicol. 2008;46(9):3023-9. PubMed PMID: 18611424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diphenyl diselenide reverses gastric lesions in rats: Involvement of oxidative stress. AU - Ineu,R P, AU - Pereira,M E, AU - Aschner,M, AU - Nogueira,C W, AU - Zeni,G, AU - Rocha,J B T, Y1 - 2008/06/20/ PY - 2007/01/31/received PY - 2008/05/26/revised PY - 2008/06/03/accepted PY - 2008/7/10/pubmed PY - 2008/11/7/medline PY - 2008/7/10/entrez SP - 3023 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 46 IS - 9 N2 - The aim of the present study was to evaluate if diphenyl diselenide administered by oral route was effective in restoring gastric lesions induced by ethanol. The possible involvement of oxidative stress in diphenyl diselenide antiulcer effect was also evaluated. Different doses of diphenyl diselenide (dissolved in soya bean oil, 1mL/kg) were administered orally 1h before (pre-treatment study) or 1h after ethanol (70%, v/v, 2mL/kg, post-treatment study). Ulcer lesions were quantified 1h after ethanol administration (pre-treatment protocol) or 1h after diphenyl diselenide study (post-treatment protocol). Diphenyl diselenide (0.1-10mg/kg or 0.32-32micromol/kg), when administered previously or posteriorly prevented and reversed respectively, the development of gastric lesions induced by ethanol in rats. A number of markers of oxidative stress were examined in rat stomach including thiobarbituric acid reactive species (TBARS), catalase (CAT), superoxide dismutase (SOD), non-protein thiol groups (NPSH) and ascorbic acid. In addition to attenuating the gastric lesions, low doses of diphenyl diselenide prevented (pre-treatment) or reversed (post-treatment) the ethanol-induced changes in TBARS, SOD activity and ascorbic acid content. In conclusion, the present data reveal that diphenyl diselenide, administered by oral route, possesses an antiulcer effect by modulating antioxidant mechanisms. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/18611424/Diphenyl_diselenide_reverses_gastric_lesions_in_rats:_Involvement_of_oxidative_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00288-3 DB - PRIME DP - Unbound Medicine ER -