Titanocene-catalyzed regioselective alkylation of styrenes with grignard reagents using beta-bromoethyl ethers, thioethers, or amines.Chem Asian J. 2008 Sep 01; 3(8-9):1472-8.CA
Abstract
Regioselective double alkylation of styrenes with alkyl Grignard reagents and alkyl bromides having a heteroatom functional group at the beta-position has been achieved by the use of a titanocene catalyst in THF. When ether was used instead of THF as a solvent, monoalkylation by substitution of a vinylic hydrogen atom with an alkyl group proceeded under similar conditions. These reactions involve the addition of alkyl radicals to styrenes to form benzylic radical intermediates.
Links
Pub Type(s)
Journal Article
Language
eng
PubMed ID
18613206
Citation
Terao, Jun, et al. "Titanocene-catalyzed Regioselective Alkylation of Styrenes With Grignard Reagents Using Beta-bromoethyl Ethers, Thioethers, or Amines." Chemistry, an Asian Journal, vol. 3, no. 8-9, 2008, pp. 1472-8.
Terao J, Kato Y, Kambe N. Titanocene-catalyzed regioselective alkylation of styrenes with grignard reagents using beta-bromoethyl ethers, thioethers, or amines. Chem Asian J. 2008;3(8-9):1472-8.
Terao, J., Kato, Y., & Kambe, N. (2008). Titanocene-catalyzed regioselective alkylation of styrenes with grignard reagents using beta-bromoethyl ethers, thioethers, or amines. Chemistry, an Asian Journal, 3(8-9), 1472-8. https://doi.org/10.1002/asia.200800134
Terao J, Kato Y, Kambe N. Titanocene-catalyzed Regioselective Alkylation of Styrenes With Grignard Reagents Using Beta-bromoethyl Ethers, Thioethers, or Amines. Chem Asian J. 2008 Sep 1;3(8-9):1472-8. PubMed PMID: 18613206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Titanocene-catalyzed regioselective alkylation of styrenes with grignard reagents using beta-bromoethyl ethers, thioethers, or amines.
AU - Terao,Jun,
AU - Kato,Yuichiro,
AU - Kambe,Nobuaki,
PY - 2008/7/10/pubmed
PY - 2008/7/10/medline
PY - 2008/7/10/entrez
SP - 1472
EP - 8
JF - Chemistry, an Asian journal
JO - Chem Asian J
VL - 3
IS - 8-9
N2 - Regioselective double alkylation of styrenes with alkyl Grignard reagents and alkyl bromides having a heteroatom functional group at the beta-position has been achieved by the use of a titanocene catalyst in THF. When ether was used instead of THF as a solvent, monoalkylation by substitution of a vinylic hydrogen atom with an alkyl group proceeded under similar conditions. These reactions involve the addition of alkyl radicals to styrenes to form benzylic radical intermediates.
SN - 1861-471X
UR - https://www.unboundmedicine.com/medline/citation/18613206/Titanocene_catalyzed_regioselective_alkylation_of_styrenes_with_grignard_reagents_using_beta_bromoethyl_ethers_thioethers_or_amines_
L2 - https://doi.org/10.1002/asia.200800134
DB - PRIME
DP - Unbound Medicine
ER -
