Tags

Type your tag names separated by a space and hit enter

Control of cardiac excitability by microRNAs.
Cardiovasc Res. 2008 Sep 01; 79(4):571-80.CR

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality in developed countries. The pathological process of the heart is associated with an altered expression profile of genes that are important for cardiac function. MicroRNAs (miRNAs) have recently emerged as one of the central players of gene expression regulation. The implications of miRNAs in the pathological process of the cardiovascular system have recently been recognized, and research on miRNAs in relation to cardiovascular disease has now become a most rapidly evolving field. In this review, we focus on miRNAs and control of cardiac excitability, aiming to provide a comprehensive overview on the available experimental data on regulation of cardiac conduction, repolarization, and automaticity by miRNAs. Aberrant expression of miRNAs in the diseased state of the heart and their arrhythmogenic or anti-arrhythmic potential will be discussed. Finally, the innovative miRNA-interference technologies developed lately for manipulating the action of miRNAs by interfering with their expression, stability, and function as new approaches for miRNA research and gene therapy will be introduced.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Yang B
Department of Pharmacology , Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China. yangbf@ems.hrbmu.edu.cn
Lu Y
No affiliation info available
Wang Z
No affiliation info available

MeSH

Action PotentialsAnimalsArrhythmias, CardiacGene Expression RegulationGenetic TherapyHeart Conduction SystemHumansIon ChannelsMicroRNAsMyocardiumPeriodicity

Pub Type(s)

Comment
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18614549

Citation

Yang, Baofeng, et al. "Control of Cardiac Excitability By MicroRNAs." Cardiovascular Research, vol. 79, no. 4, 2008, pp. 571-80.
Yang B, Lu Y, Wang Z. Control of cardiac excitability by microRNAs. Cardiovasc Res. 2008;79(4):571-80.
Yang, B., Lu, Y., & Wang, Z. (2008). Control of cardiac excitability by microRNAs. Cardiovascular Research, 79(4), 571-80. https://doi.org/10.1093/cvr/cvn181
Yang B, Lu Y, Wang Z. Control of Cardiac Excitability By MicroRNAs. Cardiovasc Res. 2008 Sep 1;79(4):571-80. PubMed PMID: 18614549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Control of cardiac excitability by microRNAs. AU - Yang,Baofeng, AU - Lu,Yanjie, AU - Wang,Zhiguo, Y1 - 2008/07/09/ PY - 2008/7/11/pubmed PY - 2008/10/4/medline PY - 2008/7/11/entrez SP - 571 EP - 80 JF - Cardiovascular research JO - Cardiovasc Res VL - 79 IS - 4 N2 - Cardiovascular disease is the leading cause of morbidity and mortality in developed countries. The pathological process of the heart is associated with an altered expression profile of genes that are important for cardiac function. MicroRNAs (miRNAs) have recently emerged as one of the central players of gene expression regulation. The implications of miRNAs in the pathological process of the cardiovascular system have recently been recognized, and research on miRNAs in relation to cardiovascular disease has now become a most rapidly evolving field. In this review, we focus on miRNAs and control of cardiac excitability, aiming to provide a comprehensive overview on the available experimental data on regulation of cardiac conduction, repolarization, and automaticity by miRNAs. Aberrant expression of miRNAs in the diseased state of the heart and their arrhythmogenic or anti-arrhythmic potential will be discussed. Finally, the innovative miRNA-interference technologies developed lately for manipulating the action of miRNAs by interfering with their expression, stability, and function as new approaches for miRNA research and gene therapy will be introduced. SN - 0008-6363 UR - https://www.unboundmedicine.com/medline/citation/18614549/Control_of_cardiac_excitability_by_microRNAs_ L2 - https://academic.oup.com/cardiovascres/article-lookup/doi/10.1093/cvr/cvn181 DB - PRIME DP - Unbound Medicine ER -