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The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels.

Abstract

CONTEXT

Lead toxicity is an ongoing concern worldwide, and children, the most vulnerable to the long-lasting effects of lead exposure, are in urgent need of a safe and effective heavy metal chelating agent to overcome the heavy metals and lead exposure challenges they face day to day.

OBJECTIVE

This clinical study was performed to determine if the oral administration of modified citrus pectin (MCP) is effective at lowering lead toxicity in the blood of children between the ages of 5 and 12 years.

METHOD

Hospitalized children with a blood serum level greater than 20 microg/dL, as measured by graphite furnace atomic absorption spectrometry (GFAAS), who had not received any form of chelating and/or detoxification medication for 3 months prior were given 15 g of MCP (PectaSol) in 3 divided dosages a day. Blood serum and 24-hour urine excretion collection GFAAS analysis were performed on day 0, day 14, day 21, and day 28.

RESULT

This study showed a dramatic decrease in blood serum levels of lead (P = .0016; 161% average change) and a dramatic increase in 24-hour urine collection (P = .0007; 132% average change).

CONCLUSION

The need for a gentle, safe heavy metal-chelating agent, especially for children with high environmental chronic exposure, is great. The dramatic results and no observed adverse effects in this pilot study along with previous reports of the safe and effective use of MCP in adults indicate that MCP could be such an agent. Further studies to confirm its benefits are justified.

Authors+Show Affiliations

,

Department of Medicine, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Republic of China.

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Source

MeSH

Adolescent
Chelation Therapy
Child
China
Citrus
Environmental Exposure
Female
Humans
Lead
Lead Poisoning, Nervous System, Childhood
Male
Pectins
Phytotherapy
Pilot Projects
Plant Extracts
Spectrophotometry, Atomic
Treatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18616067

Citation

Zhao, Zheng Yan, et al. "The Role of Modified Citrus Pectin as an Effective Chelator of Lead in Children Hospitalized With Toxic Lead Levels." Alternative Therapies in Health and Medicine, vol. 14, no. 4, 2008, pp. 34-8.
Zhao ZY, Liang L, Fan X, et al. The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels. Altern Ther Health Med. 2008;14(4):34-8.
Zhao, Z. Y., Liang, L., Fan, X., Yu, Z., Hotchkiss, A. T., Wilk, B. J., & Eliaz, I. (2008). The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels. Alternative Therapies in Health and Medicine, 14(4), pp. 34-8.
Zhao ZY, et al. The Role of Modified Citrus Pectin as an Effective Chelator of Lead in Children Hospitalized With Toxic Lead Levels. Altern Ther Health Med. 2008;14(4):34-8. PubMed PMID: 18616067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels. AU - Zhao,Zheng Yan, AU - Liang,Li, AU - Fan,Xiaoqing, AU - Yu,Zhonghua, AU - Hotchkiss,Arland T, AU - Wilk,Barry J, AU - Eliaz,Isaac, PY - 2008/7/12/pubmed PY - 2008/9/24/medline PY - 2008/7/12/entrez SP - 34 EP - 8 JF - Alternative therapies in health and medicine JO - Altern Ther Health Med VL - 14 IS - 4 N2 - CONTEXT: Lead toxicity is an ongoing concern worldwide, and children, the most vulnerable to the long-lasting effects of lead exposure, are in urgent need of a safe and effective heavy metal chelating agent to overcome the heavy metals and lead exposure challenges they face day to day. OBJECTIVE: This clinical study was performed to determine if the oral administration of modified citrus pectin (MCP) is effective at lowering lead toxicity in the blood of children between the ages of 5 and 12 years. METHOD: Hospitalized children with a blood serum level greater than 20 microg/dL, as measured by graphite furnace atomic absorption spectrometry (GFAAS), who had not received any form of chelating and/or detoxification medication for 3 months prior were given 15 g of MCP (PectaSol) in 3 divided dosages a day. Blood serum and 24-hour urine excretion collection GFAAS analysis were performed on day 0, day 14, day 21, and day 28. RESULT: This study showed a dramatic decrease in blood serum levels of lead (P = .0016; 161% average change) and a dramatic increase in 24-hour urine collection (P = .0007; 132% average change). CONCLUSION: The need for a gentle, safe heavy metal-chelating agent, especially for children with high environmental chronic exposure, is great. The dramatic results and no observed adverse effects in this pilot study along with previous reports of the safe and effective use of MCP in adults indicate that MCP could be such an agent. Further studies to confirm its benefits are justified. SN - 1078-6791 UR - https://www.unboundmedicine.com/medline/citation/18616067/The_role_of_modified_citrus_pectin_as_an_effective_chelator_of_lead_in_children_hospitalized_with_toxic_lead_levels L2 - https://ClinicalTrials.gov/search/term=18616067 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -