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Dental anomalies as part of the cleft spectrum.
Cleft Palate Craniofac J. 2008 Jul; 45(4):414-9.CP

Abstract

OBJECTIVE

The aim of this study was to determine subphenotypes of clefts based on tooth development. Dental phenotypes (tooth agenesis, supernumerary and impacted teeth, transposition, and structural anomalies) outside the cleft area in the permanent dentition of oral cleft individuals were investigated.

DESIGN

Evaluation of dental records of cleft patients.

SETTING

National Museum of Health and Medicine, Washington, D.C.

PATIENTS, PARTICIPANTS

A collection of dental casts, radiographic and clinical records of 146 patients with oral clefts was evaluated.

MAIN OUTCOME MEASURE

Association of dental anomalies with preferential subtypes of clefts.

RESULTS

Forty-seven individuals (32.19%) presented at least one dental anomaly outside the cleft area. Individuals with complete cleft lip and palate (CLP) presented more dental anomalies than individuals with incomplete CLP (p = .04). Cleft palate individuals presented more dental anomalies than CLP individuals (p = .048). Maxillary lateral incisors and premolars were the most affected teeth. High incidence of maxillary second premolar agenesis was observed in individuals with bilateral CLP (p = .04). In cases with unilateral CLP, 12.5% presented dental anomalies of the maxillary lateral incisors on the noncleft side. Cleft palate individuals presented a high incidence of mandibular premolar anomalies (p = .004).

CONCLUSION

Future studies should consider the inclusion of a complete dental description to aid in the definition of cleft subphenotypes to be studied.

Authors+Show Affiliations

Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18616370

Citation

Menezes, Renato, and Alexandre Rezende Vieira. "Dental Anomalies as Part of the Cleft Spectrum." The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association, vol. 45, no. 4, 2008, pp. 414-9.
Menezes R, Vieira AR. Dental anomalies as part of the cleft spectrum. Cleft Palate Craniofac J. 2008;45(4):414-9.
Menezes, R., & Vieira, A. R. (2008). Dental anomalies as part of the cleft spectrum. The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association, 45(4), 414-9. https://doi.org/10.1597/07-064.1
Menezes R, Vieira AR. Dental Anomalies as Part of the Cleft Spectrum. Cleft Palate Craniofac J. 2008;45(4):414-9. PubMed PMID: 18616370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dental anomalies as part of the cleft spectrum. AU - Menezes,Renato, AU - Vieira,Alexandre Rezende, Y1 - 2008/02/28/ PY - 2008/7/12/pubmed PY - 2008/10/8/medline PY - 2008/7/12/entrez SP - 414 EP - 9 JF - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JO - Cleft Palate Craniofac J VL - 45 IS - 4 N2 - OBJECTIVE: The aim of this study was to determine subphenotypes of clefts based on tooth development. Dental phenotypes (tooth agenesis, supernumerary and impacted teeth, transposition, and structural anomalies) outside the cleft area in the permanent dentition of oral cleft individuals were investigated. DESIGN: Evaluation of dental records of cleft patients. SETTING: National Museum of Health and Medicine, Washington, D.C. PATIENTS, PARTICIPANTS: A collection of dental casts, radiographic and clinical records of 146 patients with oral clefts was evaluated. MAIN OUTCOME MEASURE: Association of dental anomalies with preferential subtypes of clefts. RESULTS: Forty-seven individuals (32.19%) presented at least one dental anomaly outside the cleft area. Individuals with complete cleft lip and palate (CLP) presented more dental anomalies than individuals with incomplete CLP (p = .04). Cleft palate individuals presented more dental anomalies than CLP individuals (p = .048). Maxillary lateral incisors and premolars were the most affected teeth. High incidence of maxillary second premolar agenesis was observed in individuals with bilateral CLP (p = .04). In cases with unilateral CLP, 12.5% presented dental anomalies of the maxillary lateral incisors on the noncleft side. Cleft palate individuals presented a high incidence of mandibular premolar anomalies (p = .004). CONCLUSION: Future studies should consider the inclusion of a complete dental description to aid in the definition of cleft subphenotypes to be studied. SN - 1055-6656 UR - https://www.unboundmedicine.com/medline/citation/18616370/Dental_anomalies_as_part_of_the_cleft_spectrum_ L2 - https://journals.sagepub.com/doi/10.1597/07-064.1?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -