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DNA damage-induced gene expression in Saccharomyces cerevisiae.
FEMS Microbiol Rev. 2008 Nov; 32(6):908-26.FM

Abstract

After exposure to DNA-damaging agents, both prokaryotic and eukaryotic cells activate stress responses that result in specific alterations in patterns of gene expression. Bacteria such as Escherichia coli possess both lesion-specific responses as well as an SOS response to general DNA damage, and the molecular mechanisms of these responses are well studied. Mechanisms of DNA damage response in lower eukaryotes such as Saccharomyces cerevisiae are apparently different from those in bacteria. It becomes clear that many DNA damage-inducible genes are coregulated by the cell-cycle checkpoint, a signal transduction cascade that coordinates replication, repair, transcription and cell-cycle progression. On the other hand, among several well-characterized yeast DNA damage-inducible genes, their effectors and mechanisms of transcriptional regulation are rather different. This review attempts to summarize the current state of knowledge on the molecular mechanisms of DNA damage-induced transcriptional regulation in this model lower eukaryotic microorganism.

Links

Publisher Full Text
academic.oup.com
onlinelibrary.wiley.com

Authors+Show Affiliations

Fu Y
Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada.
Pastushok L
No affiliation info available
Xiao W
No affiliation info available

MeSH

DNA DamageGene Expression Regulation, FungalSOS Response, GeneticsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionTranscription, Genetic

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18616603

Citation

Fu, Yu, et al. "DNA Damage-induced Gene Expression in Saccharomyces Cerevisiae." FEMS Microbiology Reviews, vol. 32, no. 6, 2008, pp. 908-26.
Fu Y, Pastushok L, Xiao W. DNA damage-induced gene expression in Saccharomyces cerevisiae. FEMS Microbiol Rev. 2008;32(6):908-26.
Fu, Y., Pastushok, L., & Xiao, W. (2008). DNA damage-induced gene expression in Saccharomyces cerevisiae. FEMS Microbiology Reviews, 32(6), 908-26. https://doi.org/10.1111/j.1574-6976.2008.00126.x
Fu Y, Pastushok L, Xiao W. DNA Damage-induced Gene Expression in Saccharomyces Cerevisiae. FEMS Microbiol Rev. 2008;32(6):908-26. PubMed PMID: 18616603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DNA damage-induced gene expression in Saccharomyces cerevisiae. AU - Fu,Yu, AU - Pastushok,Landon, AU - Xiao,Wei, Y1 - 2008/06/26/ PY - 2008/7/12/pubmed PY - 2009/1/7/medline PY - 2008/7/12/entrez SP - 908 EP - 26 JF - FEMS microbiology reviews JO - FEMS Microbiol Rev VL - 32 IS - 6 N2 - After exposure to DNA-damaging agents, both prokaryotic and eukaryotic cells activate stress responses that result in specific alterations in patterns of gene expression. Bacteria such as Escherichia coli possess both lesion-specific responses as well as an SOS response to general DNA damage, and the molecular mechanisms of these responses are well studied. Mechanisms of DNA damage response in lower eukaryotes such as Saccharomyces cerevisiae are apparently different from those in bacteria. It becomes clear that many DNA damage-inducible genes are coregulated by the cell-cycle checkpoint, a signal transduction cascade that coordinates replication, repair, transcription and cell-cycle progression. On the other hand, among several well-characterized yeast DNA damage-inducible genes, their effectors and mechanisms of transcriptional regulation are rather different. This review attempts to summarize the current state of knowledge on the molecular mechanisms of DNA damage-induced transcriptional regulation in this model lower eukaryotic microorganism. SN - 0168-6445 UR - https://www.unboundmedicine.com/medline/citation/18616603/DNA_damage_induced_gene_expression_in_Saccharomyces_cerevisiae_ L2 - https://academic.oup.com/femsre/article-lookup/doi/10.1111/j.1574-6976.2008.00126.x DB - PRIME DP - Unbound Medicine ER -