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Comparative effects of propofol, landiolol, and nicardipine on hemodynamic and bispectral index responses to endotracheal intubation: a prospective, randomized, double-blinded study.
J Clin Anesth. 2008 Jun; 20(4):257-62.JC

Abstract

STUDY OBJECTIVES

To examine the comparative effects of propofol, landiolol, and nicardipine on hemodynamic responses and bispectral index (BIS) changes to endotracheal intubation.

SETTING

Operating room of a university-affiliated general hospital.

PATIENTS

27 ASA physical status I and II patients who were scheduled to undergo elective general surgical, urological, or gynecological procedures with general anesthesia.

STUDY DESIGN

Prospective, randomized, double-blinded study.

INTERVENTIONS

Patients were divided into three groups as follows: Group 1 received propofol, 1 mg/kg; Group 2 received landiolol, 0.1 mg/kg; and Group 3 received nicardipine, 1 mg. After baseline measurements were recorded, anesthesia was induced with propofol, fentanyl, and vecuronium. Patients' lungs were ventilated with 100% oxygen for 120 seconds, at which time one of one of the study drugs was administered. Laryngoscopy and tracheal intubation were performed 4 minutes after anesthetic induction.

MEASUREMENTS

Cardiac index (CI) and stroke volume index (SVI) were monitored continuously. Bispectral index was also monitored continuously from 5 minutes after tracheal intubation.

MAIN RESULTS

Heart rate values in Group 3 increased 30 seconds after intubation; this increase lasted for 1 minute after intubation. Systolic blood pressure in all three groups decreased after induction of anesthesia and before tracheal intubation, and values returned closer to baseline values 30 seconds after intubation. In the propofol group, CI and SVI decreased after administration of additional propofol, lasting for 30 seconds after intubation. The BIS values rapidly decreased after induction of anesthesia, with no intergroup differences noted in BIS values (propofol group, 39+/-7; landiolol group, 44+/-14; nicardipine group, 41+/-9). However, BIS was significantly lower in the propofol group than in the other two groups from 30 seconds to 5 minutes after intubation.

CONCLUSIONS

Landiolol, 0.1 mg/kg, before intubation provides effective hemodynamic stability in the postintubation period.

Authors+Show Affiliations

Department of Anesthesia, Tomioka General Hospital, Tomioka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18617122

Citation

Miyazaki, Masumi, et al. "Comparative Effects of Propofol, Landiolol, and Nicardipine On Hemodynamic and Bispectral Index Responses to Endotracheal Intubation: a Prospective, Randomized, Double-blinded Study." Journal of Clinical Anesthesia, vol. 20, no. 4, 2008, pp. 257-62.
Miyazaki M, Kadoi Y, Takashi S, et al. Comparative effects of propofol, landiolol, and nicardipine on hemodynamic and bispectral index responses to endotracheal intubation: a prospective, randomized, double-blinded study. J Clin Anesth. 2008;20(4):257-62.
Miyazaki, M., Kadoi, Y., Takashi, S., Sawano, Y., & Shimada, H. (2008). Comparative effects of propofol, landiolol, and nicardipine on hemodynamic and bispectral index responses to endotracheal intubation: a prospective, randomized, double-blinded study. Journal of Clinical Anesthesia, 20(4), 257-62. https://doi.org/10.1016/j.jclinane.2007.11.006
Miyazaki M, et al. Comparative Effects of Propofol, Landiolol, and Nicardipine On Hemodynamic and Bispectral Index Responses to Endotracheal Intubation: a Prospective, Randomized, Double-blinded Study. J Clin Anesth. 2008;20(4):257-62. PubMed PMID: 18617122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative effects of propofol, landiolol, and nicardipine on hemodynamic and bispectral index responses to endotracheal intubation: a prospective, randomized, double-blinded study. AU - Miyazaki,Masumi, AU - Kadoi,Yuji, AU - Takashi,Sudo, AU - Sawano,Yukari, AU - Shimada,Hitoshi, PY - 2007/05/07/received PY - 2007/09/24/revised PY - 2007/11/18/accepted PY - 2008/7/12/pubmed PY - 2008/12/17/medline PY - 2008/7/12/entrez SP - 257 EP - 62 JF - Journal of clinical anesthesia JO - J Clin Anesth VL - 20 IS - 4 N2 - STUDY OBJECTIVES: To examine the comparative effects of propofol, landiolol, and nicardipine on hemodynamic responses and bispectral index (BIS) changes to endotracheal intubation. SETTING: Operating room of a university-affiliated general hospital. PATIENTS: 27 ASA physical status I and II patients who were scheduled to undergo elective general surgical, urological, or gynecological procedures with general anesthesia. STUDY DESIGN: Prospective, randomized, double-blinded study. INTERVENTIONS: Patients were divided into three groups as follows: Group 1 received propofol, 1 mg/kg; Group 2 received landiolol, 0.1 mg/kg; and Group 3 received nicardipine, 1 mg. After baseline measurements were recorded, anesthesia was induced with propofol, fentanyl, and vecuronium. Patients' lungs were ventilated with 100% oxygen for 120 seconds, at which time one of one of the study drugs was administered. Laryngoscopy and tracheal intubation were performed 4 minutes after anesthetic induction. MEASUREMENTS: Cardiac index (CI) and stroke volume index (SVI) were monitored continuously. Bispectral index was also monitored continuously from 5 minutes after tracheal intubation. MAIN RESULTS: Heart rate values in Group 3 increased 30 seconds after intubation; this increase lasted for 1 minute after intubation. Systolic blood pressure in all three groups decreased after induction of anesthesia and before tracheal intubation, and values returned closer to baseline values 30 seconds after intubation. In the propofol group, CI and SVI decreased after administration of additional propofol, lasting for 30 seconds after intubation. The BIS values rapidly decreased after induction of anesthesia, with no intergroup differences noted in BIS values (propofol group, 39+/-7; landiolol group, 44+/-14; nicardipine group, 41+/-9). However, BIS was significantly lower in the propofol group than in the other two groups from 30 seconds to 5 minutes after intubation. CONCLUSIONS: Landiolol, 0.1 mg/kg, before intubation provides effective hemodynamic stability in the postintubation period. SN - 0952-8180 UR - https://www.unboundmedicine.com/medline/citation/18617122/Comparative_effects_of_propofol_landiolol_and_nicardipine_on_hemodynamic_and_bispectral_index_responses_to_endotracheal_intubation:_a_prospective_randomized_double_blinded_study_ DB - PRIME DP - Unbound Medicine ER -