Tags

Type your tag names separated by a space and hit enter

High prevalence of morphometric vertebral deformities in patients with inflammatory bowel disease.
Eur J Gastroenterol Hepatol. 2008 Aug; 20(8):740-7.EJ

Abstract

BACKGROUND

Earlier studies have documented that the prevalence of decreased bone mineral density (BMD) is elevated in patients with inflammatory bowel disease. The objective of this study was to investigate the prevalence of vertebral deformities in inflammatory bowel disease patients and their relation with BMD and bone turnover.

METHODS

One hundred and nine patients with Crohn's disease (CD) and 72 with ulcerative colitis (UC) (age 44.5+/-14.2 years) were studied. BMD of the hip (by dual X-ray absorptiometry) was measured and a lateral single energy densitometry of the spine for assessment of vertebral deformities was performed. Serum markers of bone resorption (carboxy-terminal cross-linked telopeptide of type I collagen) and formation (procollagen type I amino-terminal propeptide) were measured, and determinants of prevalent vertebral deformities were assessed using logistic regression analysis.

RESULTS

Vertebral deformities were found in 25% of both CD and UC patients. Comparing patients with and without vertebral deformities, no significant difference was found between Z-scores and T-scores of BMD, or levels of serum carboxy-terminal cross-linked telopeptide of type I collagen and serum procollagen type I amino-terminal propeptide. Using logistic regression analysis the only determinant of any morphometric vertebral deformity was sex. The presence of multiple vertebral deformities was associated with older age and glucocorticoid use.

CONCLUSION

The prevalence of morphometric vertebral deformities is high in CD and UC. Male sex, but neither disease activity, bone turnover markers, clinical risk factors, nor BMD predicted their presence. The determinants for having more than one vertebral deformity were age and glucocorticoid use. This implies that in addition to screening for low BMD, morphometric assessment of vertebral deformities is warranted in CD and UC.

Authors+Show Affiliations

Department of Internal Medicine, Division of Endocrinology, Hospital Bernhoven, Veghel, The Netherlands. caroline@heesen.euNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18617778

Citation

Heijckmann, Anna Caroline, et al. "High Prevalence of Morphometric Vertebral Deformities in Patients With Inflammatory Bowel Disease." European Journal of Gastroenterology & Hepatology, vol. 20, no. 8, 2008, pp. 740-7.
Heijckmann AC, Huijberts MS, Schoon EJ, et al. High prevalence of morphometric vertebral deformities in patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2008;20(8):740-7.
Heijckmann, A. C., Huijberts, M. S., Schoon, E. J., Geusens, P., de Vries, J., Menheere, P. P., van der Veer, E., Wolffenbuttel, B. H., Stockbrugger, R. W., Dumitrescu, B., & Nieuwenhuijzen Kruseman, A. C. (2008). High prevalence of morphometric vertebral deformities in patients with inflammatory bowel disease. European Journal of Gastroenterology & Hepatology, 20(8), 740-7. https://doi.org/10.1097/MEG.0b013e3282f8888b
Heijckmann AC, et al. High Prevalence of Morphometric Vertebral Deformities in Patients With Inflammatory Bowel Disease. Eur J Gastroenterol Hepatol. 2008;20(8):740-7. PubMed PMID: 18617778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of morphometric vertebral deformities in patients with inflammatory bowel disease. AU - Heijckmann,Anna Caroline, AU - Huijberts,Maya S P, AU - Schoon,Erik J, AU - Geusens,Piet, AU - de Vries,Jolanda, AU - Menheere,Paul P C A, AU - van der Veer,Eveline, AU - Wolffenbuttel,Bruce H R, AU - Stockbrugger,Reinhold W, AU - Dumitrescu,Bianca, AU - Nieuwenhuijzen Kruseman,Arie C, PY - 2008/7/12/pubmed PY - 2008/10/2/medline PY - 2008/7/12/entrez SP - 740 EP - 7 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 20 IS - 8 N2 - BACKGROUND: Earlier studies have documented that the prevalence of decreased bone mineral density (BMD) is elevated in patients with inflammatory bowel disease. The objective of this study was to investigate the prevalence of vertebral deformities in inflammatory bowel disease patients and their relation with BMD and bone turnover. METHODS: One hundred and nine patients with Crohn's disease (CD) and 72 with ulcerative colitis (UC) (age 44.5+/-14.2 years) were studied. BMD of the hip (by dual X-ray absorptiometry) was measured and a lateral single energy densitometry of the spine for assessment of vertebral deformities was performed. Serum markers of bone resorption (carboxy-terminal cross-linked telopeptide of type I collagen) and formation (procollagen type I amino-terminal propeptide) were measured, and determinants of prevalent vertebral deformities were assessed using logistic regression analysis. RESULTS: Vertebral deformities were found in 25% of both CD and UC patients. Comparing patients with and without vertebral deformities, no significant difference was found between Z-scores and T-scores of BMD, or levels of serum carboxy-terminal cross-linked telopeptide of type I collagen and serum procollagen type I amino-terminal propeptide. Using logistic regression analysis the only determinant of any morphometric vertebral deformity was sex. The presence of multiple vertebral deformities was associated with older age and glucocorticoid use. CONCLUSION: The prevalence of morphometric vertebral deformities is high in CD and UC. Male sex, but neither disease activity, bone turnover markers, clinical risk factors, nor BMD predicted their presence. The determinants for having more than one vertebral deformity were age and glucocorticoid use. This implies that in addition to screening for low BMD, morphometric assessment of vertebral deformities is warranted in CD and UC. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/18617778/High_prevalence_of_morphometric_vertebral_deformities_in_patients_with_inflammatory_bowel_disease_ L2 - https://doi.org/10.1097/MEG.0b013e3282f8888b DB - PRIME DP - Unbound Medicine ER -