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Hepatitis E autochthonous infection in chronic liver disease.
Eur J Gastroenterol Hepatol. 2008 Aug; 20(8):800-3.EJ

Abstract

Hepatitis E virus is endemic in many parts of the developing world and causes a self-limiting hepatitis in young adults, except in pregnant women and patients with chronic liver disease, where the mortality is high. Locally acquired hepatitis E is increasingly recognized in the developed world. It is caused by hepatitis E virus genotype 3, affects the middle-aged and the elderly, and may be a zoonotic infection from pigs. We present a case of locally acquired hepatitis E infection in a patient with previously undiagnosed cirrhosis, which resulted in subacute liver failure and death. We describe our attempt to trace this infection to a free-range pig farm adjacent to the patient's place of employment. Hepatitis E infection should be considered in the differential diagnosis in patients with decompensated chronic liver disease whatever their age or travel history. When found, the prognosis may be poor.

Authors+Show Affiliations

Cornwall Gastrointestinal Unit, Royal Cornwall Hospital Trust, Truro, Cornwall, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18617787

Citation

Lockwood, Gabrielle L., et al. "Hepatitis E Autochthonous Infection in Chronic Liver Disease." European Journal of Gastroenterology & Hepatology, vol. 20, no. 8, 2008, pp. 800-3.
Lockwood GL, Fernandez-Barredo S, Bendall R, et al. Hepatitis E autochthonous infection in chronic liver disease. Eur J Gastroenterol Hepatol. 2008;20(8):800-3.
Lockwood, G. L., Fernandez-Barredo, S., Bendall, R., Banks, M., Ijaz, S., & Dalton, H. R. (2008). Hepatitis E autochthonous infection in chronic liver disease. European Journal of Gastroenterology & Hepatology, 20(8), 800-3. https://doi.org/10.1097/MEG.0b013e3282f1cbff
Lockwood GL, et al. Hepatitis E Autochthonous Infection in Chronic Liver Disease. Eur J Gastroenterol Hepatol. 2008;20(8):800-3. PubMed PMID: 18617787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E autochthonous infection in chronic liver disease. AU - Lockwood,Gabrielle L, AU - Fernandez-Barredo,Salceda, AU - Bendall,Richard, AU - Banks,Malcolm, AU - Ijaz,Samreen, AU - Dalton,Harry R, PY - 2008/7/12/pubmed PY - 2008/10/2/medline PY - 2008/7/12/entrez SP - 800 EP - 3 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 20 IS - 8 N2 - Hepatitis E virus is endemic in many parts of the developing world and causes a self-limiting hepatitis in young adults, except in pregnant women and patients with chronic liver disease, where the mortality is high. Locally acquired hepatitis E is increasingly recognized in the developed world. It is caused by hepatitis E virus genotype 3, affects the middle-aged and the elderly, and may be a zoonotic infection from pigs. We present a case of locally acquired hepatitis E infection in a patient with previously undiagnosed cirrhosis, which resulted in subacute liver failure and death. We describe our attempt to trace this infection to a free-range pig farm adjacent to the patient's place of employment. Hepatitis E infection should be considered in the differential diagnosis in patients with decompensated chronic liver disease whatever their age or travel history. When found, the prognosis may be poor. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/18617787/Hepatitis_E_autochthonous_infection_in_chronic_liver_disease_ L2 - https://doi.org/10.1097/MEG.0b013e3282f1cbff DB - PRIME DP - Unbound Medicine ER -