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The role of uric acid in stroke: the issue remains unresolved.
Neurologist. 2008 Jul; 14(4):238-42.N

Abstract

BACKGROUND

Although in the past decade a large number of studies have been performed to identify the relationship between uric acid and stroke, the issue remains unresolved and it is not clear whether the correlation between uric acid and stroke is circumstantial or causal.

REVIEW SUMMARY

Some studies have found uric acid predictive for the development of cardiovascular disease, whereas others have failed to identify uric acid as a significant and independent risk factor after controlling for other atherosclerotic risk factors. Furthermore, uric acid, a powerful endogenous antioxidant, is increased in oxidative stress situations such as stroke. Still, it remains controversial whether elevated serum uric acid is neuroprotective or injurious at the onset of acute stroke.

CONCLUSIONS

Large trials are required to provide definite answers in clinical practice and to reevaluate the goals of hypouricemic treatment in subjects with increased cardiovascular risk or during an acute cardiovascular event like stroke. This review tries to keep pace with the data concerning the association between uric acid and stroke.

Authors+Show Affiliations

First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Greece.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18617849

Citation

Dimitroula, Hariklia V., et al. "The Role of Uric Acid in Stroke: the Issue Remains Unresolved." The Neurologist, vol. 14, no. 4, 2008, pp. 238-42.
Dimitroula HV, Hatzitolios AI, Karvounis HI. The role of uric acid in stroke: the issue remains unresolved. Neurologist. 2008;14(4):238-42.
Dimitroula, H. V., Hatzitolios, A. I., & Karvounis, H. I. (2008). The role of uric acid in stroke: the issue remains unresolved. The Neurologist, 14(4), 238-42. https://doi.org/10.1097/NRL.0b013e31815c666b
Dimitroula HV, Hatzitolios AI, Karvounis HI. The Role of Uric Acid in Stroke: the Issue Remains Unresolved. Neurologist. 2008;14(4):238-42. PubMed PMID: 18617849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of uric acid in stroke: the issue remains unresolved. AU - Dimitroula,Hariklia V, AU - Hatzitolios,Apostolos I, AU - Karvounis,Haralambos I, PY - 2008/7/12/pubmed PY - 2008/9/17/medline PY - 2008/7/12/entrez SP - 238 EP - 42 JF - The neurologist JO - Neurologist VL - 14 IS - 4 N2 - BACKGROUND: Although in the past decade a large number of studies have been performed to identify the relationship between uric acid and stroke, the issue remains unresolved and it is not clear whether the correlation between uric acid and stroke is circumstantial or causal. REVIEW SUMMARY: Some studies have found uric acid predictive for the development of cardiovascular disease, whereas others have failed to identify uric acid as a significant and independent risk factor after controlling for other atherosclerotic risk factors. Furthermore, uric acid, a powerful endogenous antioxidant, is increased in oxidative stress situations such as stroke. Still, it remains controversial whether elevated serum uric acid is neuroprotective or injurious at the onset of acute stroke. CONCLUSIONS: Large trials are required to provide definite answers in clinical practice and to reevaluate the goals of hypouricemic treatment in subjects with increased cardiovascular risk or during an acute cardiovascular event like stroke. This review tries to keep pace with the data concerning the association between uric acid and stroke. SN - 1074-7931 UR - https://www.unboundmedicine.com/medline/citation/18617849/The_role_of_uric_acid_in_stroke:_the_issue_remains_unresolved_ L2 - https://doi.org/10.1097/NRL.0b013e31815c666b DB - PRIME DP - Unbound Medicine ER -