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The effects of caffeine on L-arginine metabolism in the brain of rats.
Neurochem Res. 2009 Mar; 34(3):395-9.NR

Abstract

In our study, the short-term effects of caffeine on L-arginine metabolism in the brains of rats were investigated. Caffeine was given orally at two different doses: 30 mg/kg and 100 mg/kg (a high non-toxic dose). Brain tissue arginase activity in rats from the caffeine-treated groups decreased significantly compared with the control group. Malondialdehyde (MDA) levels in the brain tissue and serum of animals in the caffeine groups also decreased significantly. Brain tissue and serum nitric oxide (NO) levels increased significantly after caffeine administration. Tumor necrosis factor-alpha (TNF-alpha) levels were also investigated in rat serum, but there was no statistically significant difference between the TNF-alpha levels of the caffeine-treated rats groups and the control rats. Our study indicates that brain arginase activity decreases after caffeine administration at doses of 30 mg/kg and 100 mg/kg. As a result, we can say that arginine induces production of NO in the organism.

Authors+Show Affiliations

Faculty of Medicine, Department of Medical Biochemistry, Gazi University, Beşevler, Ankara 06510, Turkey. ebruofluoglu@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18618243

Citation

Ofluoglu, Ebru, et al. "The Effects of Caffeine On L-arginine Metabolism in the Brain of Rats." Neurochemical Research, vol. 34, no. 3, 2009, pp. 395-9.
Ofluoglu E, Pasaoglu H, Pasaoglu A. The effects of caffeine on L-arginine metabolism in the brain of rats. Neurochem Res. 2009;34(3):395-9.
Ofluoglu, E., Pasaoglu, H., & Pasaoglu, A. (2009). The effects of caffeine on L-arginine metabolism in the brain of rats. Neurochemical Research, 34(3), 395-9. https://doi.org/10.1007/s11064-008-9790-x
Ofluoglu E, Pasaoglu H, Pasaoglu A. The Effects of Caffeine On L-arginine Metabolism in the Brain of Rats. Neurochem Res. 2009;34(3):395-9. PubMed PMID: 18618243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of caffeine on L-arginine metabolism in the brain of rats. AU - Ofluoglu,Ebru, AU - Pasaoglu,Hatice, AU - Pasaoglu,Aydin, Y1 - 2008/07/10/ PY - 2007/07/07/received PY - 2008/06/19/accepted PY - 2008/7/12/pubmed PY - 2009/5/12/medline PY - 2008/7/12/entrez SP - 395 EP - 9 JF - Neurochemical research JO - Neurochem Res VL - 34 IS - 3 N2 - In our study, the short-term effects of caffeine on L-arginine metabolism in the brains of rats were investigated. Caffeine was given orally at two different doses: 30 mg/kg and 100 mg/kg (a high non-toxic dose). Brain tissue arginase activity in rats from the caffeine-treated groups decreased significantly compared with the control group. Malondialdehyde (MDA) levels in the brain tissue and serum of animals in the caffeine groups also decreased significantly. Brain tissue and serum nitric oxide (NO) levels increased significantly after caffeine administration. Tumor necrosis factor-alpha (TNF-alpha) levels were also investigated in rat serum, but there was no statistically significant difference between the TNF-alpha levels of the caffeine-treated rats groups and the control rats. Our study indicates that brain arginase activity decreases after caffeine administration at doses of 30 mg/kg and 100 mg/kg. As a result, we can say that arginine induces production of NO in the organism. SN - 1573-6903 UR - https://www.unboundmedicine.com/medline/citation/18618243/The_effects_of_caffeine_on_L_arginine_metabolism_in_the_brain_of_rats_ L2 - https://doi.org/10.1007/s11064-008-9790-x DB - PRIME DP - Unbound Medicine ER -