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[Effects of Dioscorea septemloba on the biomechanical and bone histomorphometric parameters of femur in the ovariectomized rats].
Zhong Yao Cai. 2008 Feb; 31(2):272-6.ZY

Abstract

OBJECTIVE

To investigate the effects of the decoction of Rhizoma Dioscoreae septemlobae (RD) on the biomechanical and bone histomorphometric parameters of femur in the ovariectomized rats.

METHODS

25 female Wistar rats without pregnancy and deliver were divided into 5 groups randomly: sham (sham-operation), ovariectomy (OVX), OVX + high dosage RD (4 g/kg x d), OVX + middle dosage RD (2 g/kg x d) and OVX + low dosage RD (1 g/kg x d), n = 5 in every group. After intragastric administration 12-week period continuously, the biomechanical and the bone histomorphometric parameters of the femur of the rats in every group were determined, respectively, including percentage of trabecular bone volume (TBV%), percentage of trabecular osteoid (TOS%), mean osteoid width (MOSW), percentage of mineralizing surface (MdS%), percentage of double mineralizing surface (DMds%), percentage of DMds/MdS (%), percentage of travecular formation surface (TFS%), percentage of trabecular resorption surface (TRS%), mineral apposition rate (MAR), mineralizing lag time (MLT).

RESULTS

The maximum loading, deflection, the maximum strain of the femur in the OVX group was 125.78 +/- 15.48 (N), 1.87 +/- 0.22 (mm), 9.34 +/- 1.10 (%), it was significantly lower than that in the sham group (P< 0.05, P < 0.01), respectively. The maximum loading and maximum stress was increased in different extent in the every dose group of OVX + RD, respectively. TBV% of femur was significantily lower in the OVX group than that in the sham group (P < 0.01). The MdS%, DMds%, DMds/MdS (%), TOS%, MOSW, TRS%, MAR was significantly higher in the OVX group than that in the sham group, respectively (P < 0.01). In the RA high and middle dosage group, the TBV% of femur was significantly higher than that in the model group (P < 0.05), and the MdS%, DMds%, DMds/MdS (%), TRS%, TOS%, MOSW, MAR was significantly lower than that in the model group, respectively (P < 0.05), and MLT was decurtated slightly (P > 0.05).

CONCLUSION

The decoction of RD can decline the bone turnover and the loss of bone of femur in the ovariectomized rats.

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Authors+Show Affiliations

Xing GS
The Research Institute of Orthopedics, Tianjin Hospital, Tianjin 300211, China.
Lou JS
No affiliation info available
Yu SL
No affiliation info available
Wang ZB
No affiliation info available
Shi YJ
No affiliation info available

MeSH

AnimalsBone DensityBone RemodelingBone ResorptionDioscoreaDrugs, Chinese HerbalFemaleFemurOsteoporosisOvariectomyPlants, MedicinalRandom AllocationRatsRats, WistarWeight-Bearing

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18619278

Citation

Xing, Guo-Sheng, et al. "[Effects of Dioscorea Septemloba On the Biomechanical and Bone Histomorphometric Parameters of Femur in the Ovariectomized Rats]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 31, no. 2, 2008, pp. 272-6.
Xing GS, Lou JS, Yu SL, et al. [Effects of Dioscorea septemloba on the biomechanical and bone histomorphometric parameters of femur in the ovariectomized rats]. Zhong Yao Cai. 2008;31(2):272-6.
Xing, G. S., Lou, J. S., Yu, S. L., Wang, Z. B., & Shi, Y. J. (2008). [Effects of Dioscorea septemloba on the biomechanical and bone histomorphometric parameters of femur in the ovariectomized rats]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 31(2), 272-6.
Xing GS, et al. [Effects of Dioscorea Septemloba On the Biomechanical and Bone Histomorphometric Parameters of Femur in the Ovariectomized Rats]. Zhong Yao Cai. 2008;31(2):272-6. PubMed PMID: 18619278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of Dioscorea septemloba on the biomechanical and bone histomorphometric parameters of femur in the ovariectomized rats]. AU - Xing,Guo-Sheng, AU - Lou,Jian-Shi, AU - Yu,Shun-Lu, AU - Wang,Zhi-Bin, AU - Shi,Yi-Jian, PY - 2008/7/16/pubmed PY - 2008/8/30/medline PY - 2008/7/16/entrez SP - 272 EP - 6 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 31 IS - 2 N2 - OBJECTIVE: To investigate the effects of the decoction of Rhizoma Dioscoreae septemlobae (RD) on the biomechanical and bone histomorphometric parameters of femur in the ovariectomized rats. METHODS: 25 female Wistar rats without pregnancy and deliver were divided into 5 groups randomly: sham (sham-operation), ovariectomy (OVX), OVX + high dosage RD (4 g/kg x d), OVX + middle dosage RD (2 g/kg x d) and OVX + low dosage RD (1 g/kg x d), n = 5 in every group. After intragastric administration 12-week period continuously, the biomechanical and the bone histomorphometric parameters of the femur of the rats in every group were determined, respectively, including percentage of trabecular bone volume (TBV%), percentage of trabecular osteoid (TOS%), mean osteoid width (MOSW), percentage of mineralizing surface (MdS%), percentage of double mineralizing surface (DMds%), percentage of DMds/MdS (%), percentage of travecular formation surface (TFS%), percentage of trabecular resorption surface (TRS%), mineral apposition rate (MAR), mineralizing lag time (MLT). RESULTS: The maximum loading, deflection, the maximum strain of the femur in the OVX group was 125.78 +/- 15.48 (N), 1.87 +/- 0.22 (mm), 9.34 +/- 1.10 (%), it was significantly lower than that in the sham group (P< 0.05, P < 0.01), respectively. The maximum loading and maximum stress was increased in different extent in the every dose group of OVX + RD, respectively. TBV% of femur was significantily lower in the OVX group than that in the sham group (P < 0.01). The MdS%, DMds%, DMds/MdS (%), TOS%, MOSW, TRS%, MAR was significantly higher in the OVX group than that in the sham group, respectively (P < 0.01). In the RA high and middle dosage group, the TBV% of femur was significantly higher than that in the model group (P < 0.05), and the MdS%, DMds%, DMds/MdS (%), TRS%, TOS%, MOSW, MAR was significantly lower than that in the model group, respectively (P < 0.05), and MLT was decurtated slightly (P > 0.05). CONCLUSION: The decoction of RD can decline the bone turnover and the loss of bone of femur in the ovariectomized rats. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/18619278/[Effects_of_Dioscorea_septemloba_on_the_biomechanical_and_bone_histomorphometric_parameters_of_femur_in_the_ovariectomized_rats]_ L2 - https://antibodies.cancer.gov/detail/CPTC-YWHAE-1 DB - PRIME DP - Unbound Medicine ER -