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Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory.
Brain Res. 2008 Sep 16; 1230:150-7.BR

Abstract

In the present study, the interaction between morphine and the beta-adrenergic receptor antagonist, propranolol (PROP), in memory consolidation was investigated in a two-trial recognition Y-maze task. Four sets of Y-maze experiments were carried out in mice, with 2 and 4 h inter-trial intervals (ITI) and all drugs administered immediately after the training trials. In the first and second sets of experiments, post-training administration of morphine (0.25 and 2.5 mg/kg) or PROP (2, 10 and 20 mg/kg) alone did not impair memory consolidation after a 2 h ITI. However, in the third and fourth sets of experiments, co-administration of these ineffective doses of morphine (0.25 and 2.5 mg/kg) and PROP (2, 10 and 20 mg/kg) disrupted memory consolidation after a 2 h ITI. Moreover, the relatively higher dose of morphine (2.5 mg/kg) plus the relatively higher doses of PROP (10 and 20 mg/kg) disrupted memory consolidation to a greater extent after a 2 h ITI. Locomotor activity was not affected by any of the drug treatments. Our data shows that morphine and PROP co-administration disrupts the consolidation of spatial recognition memory, suggesting that inactivation of the beta-adrenergic system may contribute to morphine-induced impairment of memory.

Authors+Show Affiliations

Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18619418

Citation

Zhang, Jie, et al. "Morphine and Propranolol Co-administration Impair Consolidation of Y-maze Spatial Recognition Memory." Brain Research, vol. 1230, 2008, pp. 150-7.
Zhang J, He J, Chen YM, et al. Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory. Brain Res. 2008;1230:150-7.
Zhang, J., He, J., Chen, Y. M., Wang, J. H., & Ma, Y. Y. (2008). Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory. Brain Research, 1230, 150-7. https://doi.org/10.1016/j.brainres.2008.06.061
Zhang J, et al. Morphine and Propranolol Co-administration Impair Consolidation of Y-maze Spatial Recognition Memory. Brain Res. 2008 Sep 16;1230:150-7. PubMed PMID: 18619418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory. AU - Zhang,Jie, AU - He,Jing, AU - Chen,Yan Mei, AU - Wang,Jian Hong, AU - Ma,Yuan Ye, Y1 - 2008/06/25/ PY - 2008/01/23/received PY - 2008/03/31/revised PY - 2008/06/17/accepted PY - 2008/7/16/pubmed PY - 2008/12/17/medline PY - 2008/7/16/entrez SP - 150 EP - 7 JF - Brain research JO - Brain Res VL - 1230 N2 - In the present study, the interaction between morphine and the beta-adrenergic receptor antagonist, propranolol (PROP), in memory consolidation was investigated in a two-trial recognition Y-maze task. Four sets of Y-maze experiments were carried out in mice, with 2 and 4 h inter-trial intervals (ITI) and all drugs administered immediately after the training trials. In the first and second sets of experiments, post-training administration of morphine (0.25 and 2.5 mg/kg) or PROP (2, 10 and 20 mg/kg) alone did not impair memory consolidation after a 2 h ITI. However, in the third and fourth sets of experiments, co-administration of these ineffective doses of morphine (0.25 and 2.5 mg/kg) and PROP (2, 10 and 20 mg/kg) disrupted memory consolidation after a 2 h ITI. Moreover, the relatively higher dose of morphine (2.5 mg/kg) plus the relatively higher doses of PROP (10 and 20 mg/kg) disrupted memory consolidation to a greater extent after a 2 h ITI. Locomotor activity was not affected by any of the drug treatments. Our data shows that morphine and PROP co-administration disrupts the consolidation of spatial recognition memory, suggesting that inactivation of the beta-adrenergic system may contribute to morphine-induced impairment of memory. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/18619418/Morphine_and_propranolol_co_administration_impair_consolidation_of_Y_maze_spatial_recognition_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(08)01520-5 DB - PRIME DP - Unbound Medicine ER -