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Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation.
Exp Neurol. 2008 Sep; 213(1):108-13.EN

Abstract

Parkinson's disease is treated pharmacologically with dopamine replacement medication and, more recently, by stimulating basal-ganglia nuclei such as the subthalamic nucleus (STN). Depth recordings after this procedure have revealed excessive activity at frequencies between 8 and 35 Hz (Brown et al., 2001; Kuhn et al., 2004; Priori et al., 2004) that are reduced by dopamine therapy in tandem with improvements in bradykinesia/rigidity, but not tremor (Kuhn et al., 2006). It has also been shown that improvements in motor symptoms after dopamine correlate with single unit activity in the beta range (Weinberger et al., 2006). We recorded local field potentials (LFPs) from the subthalamic nucleus of patients with Parkinson's disease (PD) after surgery to implant deep brain stimulating electrodes while they were on and off dopaminergic medication. As well as replicating Kuhn et al., using the same patients we were able to extend Weinberger et al. to show that LFP beta oscillatory activity correlated with the degree of improvement in bradykinesia/rigidity, but not tremor, after dopamine medication. We also found that the power of beta oscillatory activity uniquely predicted improvements in bradykinesia/rigidity, but again not tremor, after stimulation of the STN in a regression analysis. However improvements after STN stimulation related inversely to beta power, possibly reflecting the accuracy of the electrode placement and/or the limits of STN stimulation in patients with the greatest levels of beta oscillatory activity.

Authors+Show Affiliations

Department of Anatomy, Physiology and Genetics, University of Oxford, Parks Road, OX1 3PT, USA. nicola.ray@DPAG.ox.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18619592

Citation

Ray, N J., et al. "Local Field Potential Beta Activity in the Subthalamic Nucleus of Patients With Parkinson's Disease Is Associated With Improvements in Bradykinesia After Dopamine and Deep Brain Stimulation." Experimental Neurology, vol. 213, no. 1, 2008, pp. 108-13.
Ray NJ, Jenkinson N, Wang S, et al. Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. Exp Neurol. 2008;213(1):108-13.
Ray, N. J., Jenkinson, N., Wang, S., Holland, P., Brittain, J. S., Joint, C., Stein, J. F., & Aziz, T. (2008). Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. Experimental Neurology, 213(1), 108-13. https://doi.org/10.1016/j.expneurol.2008.05.008
Ray NJ, et al. Local Field Potential Beta Activity in the Subthalamic Nucleus of Patients With Parkinson's Disease Is Associated With Improvements in Bradykinesia After Dopamine and Deep Brain Stimulation. Exp Neurol. 2008;213(1):108-13. PubMed PMID: 18619592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. AU - Ray,N J, AU - Jenkinson,N, AU - Wang,S, AU - Holland,P, AU - Brittain,J S, AU - Joint,C, AU - Stein,J F, AU - Aziz,T, Y1 - 2008/05/22/ PY - 2008/03/25/received PY - 2008/05/05/revised PY - 2008/05/05/accepted PY - 2008/7/16/pubmed PY - 2008/9/16/medline PY - 2008/7/16/entrez SP - 108 EP - 13 JF - Experimental neurology JO - Exp Neurol VL - 213 IS - 1 N2 - Parkinson's disease is treated pharmacologically with dopamine replacement medication and, more recently, by stimulating basal-ganglia nuclei such as the subthalamic nucleus (STN). Depth recordings after this procedure have revealed excessive activity at frequencies between 8 and 35 Hz (Brown et al., 2001; Kuhn et al., 2004; Priori et al., 2004) that are reduced by dopamine therapy in tandem with improvements in bradykinesia/rigidity, but not tremor (Kuhn et al., 2006). It has also been shown that improvements in motor symptoms after dopamine correlate with single unit activity in the beta range (Weinberger et al., 2006). We recorded local field potentials (LFPs) from the subthalamic nucleus of patients with Parkinson's disease (PD) after surgery to implant deep brain stimulating electrodes while they were on and off dopaminergic medication. As well as replicating Kuhn et al., using the same patients we were able to extend Weinberger et al. to show that LFP beta oscillatory activity correlated with the degree of improvement in bradykinesia/rigidity, but not tremor, after dopamine medication. We also found that the power of beta oscillatory activity uniquely predicted improvements in bradykinesia/rigidity, but again not tremor, after stimulation of the STN in a regression analysis. However improvements after STN stimulation related inversely to beta power, possibly reflecting the accuracy of the electrode placement and/or the limits of STN stimulation in patients with the greatest levels of beta oscillatory activity. SN - 1090-2430 UR - https://www.unboundmedicine.com/medline/citation/18619592/Local_field_potential_beta_activity_in_the_subthalamic_nucleus_of_patients_with_Parkinson's_disease_is_associated_with_improvements_in_bradykinesia_after_dopamine_and_deep_brain_stimulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(08)00217-3 DB - PRIME DP - Unbound Medicine ER -