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Pharmacotherapy of otitis media.
Pharmacotherapy. 1991; 11(3):212-21.P

Abstract

The clinical manifestations of acute otitis media and otitis media with effusion are the result of abnormal eustachian tube function most often caused by inflammation from infection or allergy. The majority of cases involve bacterial infection of the middle ear caused by Streptococcus pneumoniae, Haemophilus influenzae, or Branhamella catarrhalis. Nearly half of all children will have had at least one episode of acute otitis media by 1 year of age, and over 70% by 3 years of age. The signs and symptoms include pain with rubbing or tugging at the ear, fever, irritability, lethargy, and hearing loss. The primary therapy for acute otitis media and otitis media with effusion is antibiotics with the goal of preventing possible complications and providing symptomatic relief. Amoxicillin remains the initial drug of choice in communities where beta-lactamase-producing strains of the common middle ear pathogens are infrequently isolated. If resistant organisms are prevalent, cefaclor, amoxicillin-clavulanate, or cotrimoxazole should be selected. Adjuvant agents such as decongestants have not been shown to provide additional therapeutic benefit. Children who develop chronic otitis media may require prophylactic antibiotic therapy and insertion of typanostomy tubes.

Authors+Show Affiliations

Thoene DE
Department of Pharmacy Services, University of Michigan Medical Center, Ann Arbor.
Johnson CE
No affiliation info available

MeSH

Acute DiseaseAnti-Bacterial AgentsBacterial InfectionsChildChild, PreschoolHumansInfantInfant, NewbornOtitis Media

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1862012

Citation

Thoene, D E., and C E. Johnson. "Pharmacotherapy of Otitis Media." Pharmacotherapy, vol. 11, no. 3, 1991, pp. 212-21.
Thoene DE, Johnson CE. Pharmacotherapy of otitis media. Pharmacotherapy. 1991;11(3):212-21.
Thoene, D. E., & Johnson, C. E. (1991). Pharmacotherapy of otitis media. Pharmacotherapy, 11(3), 212-21.
Thoene DE, Johnson CE. Pharmacotherapy of Otitis Media. Pharmacotherapy. 1991;11(3):212-21. PubMed PMID: 1862012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacotherapy of otitis media. AU - Thoene,D E, AU - Johnson,C E, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 212 EP - 21 JF - Pharmacotherapy JO - Pharmacotherapy VL - 11 IS - 3 N2 - The clinical manifestations of acute otitis media and otitis media with effusion are the result of abnormal eustachian tube function most often caused by inflammation from infection or allergy. The majority of cases involve bacterial infection of the middle ear caused by Streptococcus pneumoniae, Haemophilus influenzae, or Branhamella catarrhalis. Nearly half of all children will have had at least one episode of acute otitis media by 1 year of age, and over 70% by 3 years of age. The signs and symptoms include pain with rubbing or tugging at the ear, fever, irritability, lethargy, and hearing loss. The primary therapy for acute otitis media and otitis media with effusion is antibiotics with the goal of preventing possible complications and providing symptomatic relief. Amoxicillin remains the initial drug of choice in communities where beta-lactamase-producing strains of the common middle ear pathogens are infrequently isolated. If resistant organisms are prevalent, cefaclor, amoxicillin-clavulanate, or cotrimoxazole should be selected. Adjuvant agents such as decongestants have not been shown to provide additional therapeutic benefit. Children who develop chronic otitis media may require prophylactic antibiotic therapy and insertion of typanostomy tubes. SN - 0277-0008 UR - https://www.unboundmedicine.com/medline/citation/1862012/Pharmacotherapy_of_otitis_media_ DB - PRIME DP - Unbound Medicine ER -