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Comparison of short bowel syndrome acquired early in life and during adolescence.
Transplantation. 2008 Jul 15; 86(1):63-6.T

Abstract

BACKGROUND

Prolonged survival in pediatric patients with short bowel syndrome (SBS) is now possible because of parenteral nutrition and small bowel transplantation. We hypothesized that there may be important differences between adult patients who developed SBS during early childhood and those who develop this as adolescents.

METHODS

Sixty-seven patients between the ages of 16 and 40 years were studied. Thirty patients developing SBS younger than 12 years comprised the pediatric group (PG), 37 developing SBS at age 13 to 25 constituted the adolescent group (AG).

RESULTS

Midgut volvulus (n=11) was the most common cause in the PG followed by gastroschisis (n=5), intestinal atresia (n=5), and necrotizing enterocolitis (n=4). The most common cause of SBS in the AG was trauma (n=13), followed by tumors (n=7) and postoperative complications (n=5). A similar portion in each group had intestinal remnants less than 60 cm (69% vs. 58%), however, the PG was more likely to have a colon remnant (97% vs. 71%, P<0.05), and less likely to have an ostomy (7% vs. 47%, P<0.05). Patients in PG were followed significantly longer than AG (246+/-67 vs. 90+/-58 months, P<0.05). A similar portion of the patients require long-term parenteral nutrition (86% vs. 84%) or have undergone intestinal transplant (28% vs. 23%). Significantly more pediatric patients had negative height z scores when compared with the adolescents.

CONCLUSIONS

Acknowledging the inherent biases created in defining the two groups, pediatric patients developing SBS early in life seem to be similar to those who develop SBS as adolescents with regards to long-term outcome, despite differences in origin and intestinal anatomy.

Authors+Show Affiliations

Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA. mbruzoni@unmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18622279

Citation

Bruzoni, Matias, et al. "Comparison of Short Bowel Syndrome Acquired Early in Life and During Adolescence." Transplantation, vol. 86, no. 1, 2008, pp. 63-6.
Bruzoni M, Sudan DL, Cusick RA, et al. Comparison of short bowel syndrome acquired early in life and during adolescence. Transplantation. 2008;86(1):63-6.
Bruzoni, M., Sudan, D. L., Cusick, R. A., & Thompson, J. S. (2008). Comparison of short bowel syndrome acquired early in life and during adolescence. Transplantation, 86(1), 63-6. https://doi.org/10.1097/TP.0b013e3181734995
Bruzoni M, et al. Comparison of Short Bowel Syndrome Acquired Early in Life and During Adolescence. Transplantation. 2008 Jul 15;86(1):63-6. PubMed PMID: 18622279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of short bowel syndrome acquired early in life and during adolescence. AU - Bruzoni,Matias, AU - Sudan,Debra L, AU - Cusick,Robert A, AU - Thompson,Jon S, PY - 2008/7/16/pubmed PY - 2008/8/22/medline PY - 2008/7/16/entrez SP - 63 EP - 6 JF - Transplantation JO - Transplantation VL - 86 IS - 1 N2 - BACKGROUND: Prolonged survival in pediatric patients with short bowel syndrome (SBS) is now possible because of parenteral nutrition and small bowel transplantation. We hypothesized that there may be important differences between adult patients who developed SBS during early childhood and those who develop this as adolescents. METHODS: Sixty-seven patients between the ages of 16 and 40 years were studied. Thirty patients developing SBS younger than 12 years comprised the pediatric group (PG), 37 developing SBS at age 13 to 25 constituted the adolescent group (AG). RESULTS: Midgut volvulus (n=11) was the most common cause in the PG followed by gastroschisis (n=5), intestinal atresia (n=5), and necrotizing enterocolitis (n=4). The most common cause of SBS in the AG was trauma (n=13), followed by tumors (n=7) and postoperative complications (n=5). A similar portion in each group had intestinal remnants less than 60 cm (69% vs. 58%), however, the PG was more likely to have a colon remnant (97% vs. 71%, P<0.05), and less likely to have an ostomy (7% vs. 47%, P<0.05). Patients in PG were followed significantly longer than AG (246+/-67 vs. 90+/-58 months, P<0.05). A similar portion of the patients require long-term parenteral nutrition (86% vs. 84%) or have undergone intestinal transplant (28% vs. 23%). Significantly more pediatric patients had negative height z scores when compared with the adolescents. CONCLUSIONS: Acknowledging the inherent biases created in defining the two groups, pediatric patients developing SBS early in life seem to be similar to those who develop SBS as adolescents with regards to long-term outcome, despite differences in origin and intestinal anatomy. SN - 0041-1337 UR - https://www.unboundmedicine.com/medline/citation/18622279/Comparison_of_short_bowel_syndrome_acquired_early_in_life_and_during_adolescence_ L2 - https://doi.org/10.1097/TP.0b013e3181734995 DB - PRIME DP - Unbound Medicine ER -