Tags

Type your tag names separated by a space and hit enter

Metabolic syndrome and Alzheimer's disease: a link to a vascular hypothesis?

Abstract

Current evidence from epidemiological, neuroimaging, pathological, pharmacotherapeutic, and clinical studies indicate an association of Alzheimer's disease with risk factors of vascular atherosclerotic disease either in isolation or in aggregate. "Metabolic syndrome" (MetS) is the name for a clustering of risk factors for cardiovascular disease and type 2 diabetes that are of metabolic origin. These include central obesity, elevated plasma glucose, high blood pressure, atherogenic dyslipidemia, a prothrombotic state, and a proinflammatory state. In this article, we provide an overview of the relevant literature with regard to the relationship of Alzheimer's disease with MetS. Accumulating evidence suggests a "vascular hypothesis" to be related to the pathology of Alzheimer's disease. In the light of this evidence, clinician may consider lifestyle interventions toward an early and effective cardiovascular risk-factor management to reduce the cardiometabolic and the cognitive decline risk, while further research of other preventive strategies may be warranted.

Authors+Show Affiliations

,

Department of Internal Medicine, University of Ioannina School of Medicine, Ioannina, Greece.

,

Source

CNS spectrums 13:7 2008 Jul pg 606-13

MeSH

Alzheimer Disease
Atherosclerosis
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Humans
Life Style
Metabolic Syndrome
Obesity
Risk Factors
Vascular Diseases

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18622365

Citation

Milionis, Haralampos J., et al. "Metabolic Syndrome and Alzheimer's Disease: a Link to a Vascular Hypothesis?" CNS Spectrums, vol. 13, no. 7, 2008, pp. 606-13.
Milionis HJ, Florentin M, Giannopoulos S. Metabolic syndrome and Alzheimer's disease: a link to a vascular hypothesis? CNS Spectr. 2008;13(7):606-13.
Milionis, H. J., Florentin, M., & Giannopoulos, S. (2008). Metabolic syndrome and Alzheimer's disease: a link to a vascular hypothesis? CNS Spectrums, 13(7), pp. 606-13.
Milionis HJ, Florentin M, Giannopoulos S. Metabolic Syndrome and Alzheimer's Disease: a Link to a Vascular Hypothesis. CNS Spectr. 2008;13(7):606-13. PubMed PMID: 18622365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome and Alzheimer's disease: a link to a vascular hypothesis? AU - Milionis,Haralampos J, AU - Florentin,Matilda, AU - Giannopoulos,Sotirios, PY - 2008/7/16/pubmed PY - 2008/9/13/medline PY - 2008/7/16/entrez SP - 606 EP - 13 JF - CNS spectrums JO - CNS Spectr VL - 13 IS - 7 N2 - Current evidence from epidemiological, neuroimaging, pathological, pharmacotherapeutic, and clinical studies indicate an association of Alzheimer's disease with risk factors of vascular atherosclerotic disease either in isolation or in aggregate. "Metabolic syndrome" (MetS) is the name for a clustering of risk factors for cardiovascular disease and type 2 diabetes that are of metabolic origin. These include central obesity, elevated plasma glucose, high blood pressure, atherogenic dyslipidemia, a prothrombotic state, and a proinflammatory state. In this article, we provide an overview of the relevant literature with regard to the relationship of Alzheimer's disease with MetS. Accumulating evidence suggests a "vascular hypothesis" to be related to the pathology of Alzheimer's disease. In the light of this evidence, clinician may consider lifestyle interventions toward an early and effective cardiovascular risk-factor management to reduce the cardiometabolic and the cognitive decline risk, while further research of other preventive strategies may be warranted. SN - 1092-8529 UR - https://www.unboundmedicine.com/medline/citation/18622365/Metabolic_syndrome_and_Alzheimer's_disease:_a_link_to_a_vascular_hypothesis L2 - https://medlineplus.gov/metabolicsyndrome.html DB - PRIME DP - Unbound Medicine ER -