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Working memory and depressive symptoms in patients with schizophrenia and substance use disorders.
Cogn Neuropsychiatry. 2008 Jul; 13(4):357-66.CN

Abstract

BACKGROUND

Substance abuse is highly prevalent in schizophrenia and it has been associated with negative consequences on the course of the pathology. Regarding cognition, the prevailing literature has produced mixed results. Some groups have reported greater cognitive impairments in dual diagnosis schizophrenia, while other groups have described the reverse.

OBJECTIVE

The current cross-sectional study sought to investigate the potential differences in psychiatric symptoms and cognition between schizophrenia patients with and without substance use disorders.

METHODS

Fifty-three schizophrenia patients were divided into two groups: with (n=30) and without (n=23) a substance use disorder (DSM-IV criteria). Psychiatric symptoms were measured with the Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS). Psychomotor speed and spatial working memory were measured using Cambridge Neuropsychological Tests Automated Battery (CANTAB).

RESULTS

Patients in the dual diagnosis group displayed more severe depressive symptoms and poorer strategy during the working memory task.

CONCLUSIONS

These results are in keeping with the prevailing literature describing negative consequences of substance abuse in schizophrenia. Substance abuse may exacerbate depressive symptoms and interfere with metacognition in schizophrenia.

Authors+Show Affiliations

Fernand-Seguin Research Center, University of Montreal, Montreal, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18622790

Citation

Potvin, Stéphane, et al. "Working Memory and Depressive Symptoms in Patients With Schizophrenia and Substance Use Disorders." Cognitive Neuropsychiatry, vol. 13, no. 4, 2008, pp. 357-66.
Potvin S, Pampoulova T, Lipp O, et al. Working memory and depressive symptoms in patients with schizophrenia and substance use disorders. Cogn Neuropsychiatry. 2008;13(4):357-66.
Potvin, S., Pampoulova, T., Lipp, O., Ait Bentaleb, L., Lalonde, P., & Stip, E. (2008). Working memory and depressive symptoms in patients with schizophrenia and substance use disorders. Cognitive Neuropsychiatry, 13(4), 357-66. https://doi.org/10.1080/13546800802264330
Potvin S, et al. Working Memory and Depressive Symptoms in Patients With Schizophrenia and Substance Use Disorders. Cogn Neuropsychiatry. 2008;13(4):357-66. PubMed PMID: 18622790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Working memory and depressive symptoms in patients with schizophrenia and substance use disorders. AU - Potvin,Stéphane, AU - Pampoulova,Tania, AU - Lipp,Olivier, AU - Ait Bentaleb,Lahcen, AU - Lalonde,Pierre, AU - Stip,Emmanuel, PY - 2008/7/16/pubmed PY - 2008/9/26/medline PY - 2008/7/16/entrez SP - 357 EP - 66 JF - Cognitive neuropsychiatry JO - Cogn Neuropsychiatry VL - 13 IS - 4 N2 - BACKGROUND: Substance abuse is highly prevalent in schizophrenia and it has been associated with negative consequences on the course of the pathology. Regarding cognition, the prevailing literature has produced mixed results. Some groups have reported greater cognitive impairments in dual diagnosis schizophrenia, while other groups have described the reverse. OBJECTIVE: The current cross-sectional study sought to investigate the potential differences in psychiatric symptoms and cognition between schizophrenia patients with and without substance use disorders. METHODS: Fifty-three schizophrenia patients were divided into two groups: with (n=30) and without (n=23) a substance use disorder (DSM-IV criteria). Psychiatric symptoms were measured with the Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS). Psychomotor speed and spatial working memory were measured using Cambridge Neuropsychological Tests Automated Battery (CANTAB). RESULTS: Patients in the dual diagnosis group displayed more severe depressive symptoms and poorer strategy during the working memory task. CONCLUSIONS: These results are in keeping with the prevailing literature describing negative consequences of substance abuse in schizophrenia. Substance abuse may exacerbate depressive symptoms and interfere with metacognition in schizophrenia. SN - 1464-0619 UR - https://www.unboundmedicine.com/medline/citation/18622790/Working_memory_and_depressive_symptoms_in_patients_with_schizophrenia_and_substance_use_disorders_ L2 - https://www.tandfonline.com/doi/full/10.1080/13546800802264330 DB - PRIME DP - Unbound Medicine ER -